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Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment
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Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment.pdf | Published version | 2.07 MB | Adobe PDF | View/Open |
Title: | Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment |
Authors: | Singh, M Nabavi, E Zhou, Y Gallina, ME Zhao, H Ruenraroengsak, P Porter, AE Ma, D Cass, AEG Hanna, GB Elson, DS |
Item Type: | Journal Article |
Abstract: | Endoscopy is the gold standard investigation in the diagnosis of gastrointestinal cancers and the management of early and pre-malignant lesions either by resection or ablation. Recently gold nanoparticles have shown promise in cancer diagnosis and therapeutics (theranostics). The combination of multifunctional gold nanoparticles with near infrared fluorescence endoscopy for accurate mapping of early or pre-malignant lesions can potentially enhance diagnostic efficiency while precisely directing endoscopic near infrared photothermal therapy for established cancers. The integration of endoscopy with near infrared fluorescence imaging and photothermal therapy was aided by the accumulation of our multifunctionalized PEG-GNR-Cy5.5-anti-EGFR-antibody gold nanorods within gastrointestinal tumor xenografts in BALB/c mice. Control mice (with tumors) received either gold nanorods or photothermal therapy, while study mice received both treatment modalities. Local (tumor-centric) and systemic effects were examined for 30 days. Clear endoscopic near infrared fluorescence signals were observed emanating specifically from tumor sites and these corresponded precisely to the tumor margins. Endoscopic fluorescence-guided near infrared photothermal therapy successfully induced tumor ablations in all 20 mice studied, with complete histological clearance and minimal collateral damage. Multi-source analysis from histology, electron microscopy, mass spectrometry, blood, clinical evaluation, psychosocial and weight monitoring demonstrated the inherent safety of this technology. The combination of this innovative nanotechnology with gold standard clinical practice will be of value in enhancing the early optical detection of gastrointestinal cancers and a useful adjunct for its therapy. |
Issue Date: | 29-Jan-2019 |
Date of Acceptance: | 17-Dec-2018 |
URI: | http://hdl.handle.net/10044/1/68689 |
DOI: | 10.7150/ntno.28585 |
ISSN: | 2206-7418 |
Publisher: | Ivyspring International Publisher |
Start Page: | 89 |
End Page: | 102 |
Journal / Book Title: | Nanotheranostics |
Volume: | 3 |
Issue: | 1 |
Copyright Statement: | © 2019 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
Sponsor/Funder: | Imperial College Healthcare NHS Trust- BRC Funding Commission of the European Communities Cancer Research UK Imperial College Healthcare NHS Trust- BRC Funding Imperial College Healthcare NHS Trust- BRC Funding National Institute for Health Research |
Funder's Grant Number: | RDF01 79560 242991 25147 RDB04 79560 RD207 II-LB-0214-20009 |
Keywords: | Photothermal therapy fluorescence endoscopy gold nanoparticles image-guided therapy near infrared fluorescence surgical technology theranostics Animals Cell Line, Tumor Gold Humans Hyperthermia, Induced Laparoscopy Male Metal Nanoparticles Mice Mice, Nude Nanotubes Neoplasms, Experimental Optical Imaging Phototherapy Xenograft Model Antitumor Assays Cell Line, Tumor Animals Humans Mice Mice, Nude Neoplasms, Experimental Gold Laparoscopy Hyperthermia, Induced Phototherapy Xenograft Model Antitumor Assays Nanotubes Male Metal Nanoparticles Optical Imaging |
Publication Status: | Published |
Online Publication Date: | 2019-01-29 |
Appears in Collections: | Materials Department of Surgery and Cancer Chemistry Biological and Biophysical Chemistry Faculty of Medicine Faculty of Natural Sciences Faculty of Engineering |