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Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry
File | Description | Size | Format | |
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Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry.docx | Accepted version | 1.54 MB | Microsoft Word | View/Open |
Title: | Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry |
Authors: | Allott, L Barnes, C Brickute, D Leung, SFJ Aboagye, EO |
Item Type: | Journal Article |
Abstract: | A solid-supported cyanoborohydride cartridge was designed to facilitate the automated production of positron emission tomography (PET) radiotracers synthesised via reductive amination chemistry. Two compounds, N-(4-fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)ethan-1-amine ([18F]2) and 1,3,4,6-tetra-O-acetyl-2-(4-fluorobenzylamine)-2-deoxy-β-D-glucopyranose ([18F]4) were radiosynthesised efficiently using a GE FASTlab™ platform, obtained in >98% RCP in a total synthesis time of 75 min (from the start of synthesis) with RCY (non-decay corrected) of 7.5 ± 2.5% and 6.0 ± 1.1%, respectively. The cartridge method provides a convenient alternative to conventional powdered reducing agents typically used in reductive amination radiochemistry. |
Issue Date: | 1-Oct-2019 |
Date of Acceptance: | 25-Jul-2019 |
URI: | http://hdl.handle.net/10044/1/81738 |
DOI: | 10.1039/c9re00226j |
ISSN: | 2058-9883 |
Publisher: | Royal Society of Chemistry |
Start Page: | 1748 |
End Page: | 1751 |
Journal / Book Title: | Reaction Chemistry and Engineering |
Volume: | 4 |
Issue: | 10 |
Copyright Statement: | © 2020 Authors |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering F-18 PROTEIN C-11 Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering F-18 PROTEIN C-11 |
Publication Status: | Published |
Online Publication Date: | 2019-07-25 |
Appears in Collections: | Department of Surgery and Cancer Division of Cancer |