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Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry

Title: Solid-supported cyanoborohydride cartridges for automation of reductive amination radiochemistry
Authors: Allott, L
Barnes, C
Brickute, D
Leung, SFJ
Aboagye, EO
Item Type: Journal Article
Abstract: A solid-supported cyanoborohydride cartridge was designed to facilitate the automated production of positron emission tomography (PET) radiotracers synthesised via reductive amination chemistry. Two compounds, N-(4-fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)ethan-1-amine ([18F]2) and 1,3,4,6-tetra-O-acetyl-2-(4-fluorobenzylamine)-2-deoxy-β-D-glucopyranose ([18F]4) were radiosynthesised efficiently using a GE FASTlab™ platform, obtained in >98% RCP in a total synthesis time of 75 min (from the start of synthesis) with RCY (non-decay corrected) of 7.5 ± 2.5% and 6.0 ± 1.1%, respectively. The cartridge method provides a convenient alternative to conventional powdered reducing agents typically used in reductive amination radiochemistry.
Issue Date: 1-Oct-2019
Date of Acceptance: 25-Jul-2019
URI: http://hdl.handle.net/10044/1/81738
DOI: 10.1039/c9re00226j
ISSN: 2058-9883
Publisher: Royal Society of Chemistry
Start Page: 1748
End Page: 1751
Journal / Book Title: Reaction Chemistry and Engineering
Volume: 4
Issue: 10
Copyright Statement: © 2020 Authors
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Engineering, Chemical
Chemistry
Engineering
F-18
PROTEIN
C-11
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Engineering, Chemical
Chemistry
Engineering
F-18
PROTEIN
C-11
Publication Status: Published
Online Publication Date: 2019-07-25
Appears in Collections:Department of Surgery and Cancer
Division of Cancer