106
IRUS Total
Downloads
  Altmetric

Assessment of hemodynamic conditions in the aorta following root replacement with composite valve-conduit graft

File Description SizeFormat 
Paper_Cheng accepted version.pdfAccepted version2.68 MBAdobe PDFView/Open
Title: Assessment of hemodynamic conditions in the aorta following root replacement with composite valve-conduit graft
Authors: Cheng, Z
Kidher, E
Jarral, OA
O'Regan, DP
Wood, NB
Athanasiou, T
Xu, XY
Item Type: Journal Article
Abstract: This paper presents the analysis of detailed hemodynamics in the aortas of four patients following replacement with a composite bio-prosthetic valve-conduit. Magnetic resonance image-based computational models were set up for each patient with boundary conditions comprising subject-specific three-dimensional inflow velocity profiles at the aortic root and central pressure waveform at the model outlet. Two normal subjects were also included for comparison. The purpose of the study was to investigate the effects of the valve-conduit on flow in the proximal and distal aorta. The results suggested that following the composite valve-conduit implantation, the vortical flow structure and hemodynamic parameters in the aorta were altered, with slightly reduced helical flow index, elevated wall shear stress and higher non-uniformity in wall shear compared to normal aortas. Inter-individual analysis revealed different hemodynamic conditions among the patients depending on the conduit configuration in the ascending aorta, which is a key factor in determining post-operative aortic flow. Introducing a natural curvature in the conduit to create a smooth transition between the conduit and native aorta may help prevent the occurrence of retrograde and recirculating flow in the aortic arch, which is particularly important when a large portion or the entire ascending aorta needs to be replaced.
Issue Date: 1-May-2016
Date of Acceptance: 7-Sep-2015
URI: http://hdl.handle.net/10044/1/26713
DOI: 10.1007/s10439-015-1453-x
ISSN: 0090-6964
Publisher: Springer
Start Page: 1392
End Page: 1404
Journal / Book Title: Annals of Biomedical Engineering
Volume: 44
Issue: 5
Copyright Statement: © 2015 Biomedical Engineering Society. The final publication is available at Springer via https://dx.doi.org/10.1007/s10439-015-1453-x
Sponsor/Funder: Commission of the European Communities
British Heart Foundation
BP International Limited
Imperial Health Charity
Wellcome Trust
Sanofi Pasteur
Imperial College Healthcare NHS Trust
Engineering & Physical Science Research Council (EPSRC)
Biotechnology and Biological Sciences Research Cou
Wellcome Trust
Imperial College Healthcare NHS Trust- BRC Funding
Imperial Health Charity
Imperial College Healthcare Charity
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Wellcome Trust
Imperial College Healthcare NHS Trust- BRC Funding
Kaust UK Ltd
Imperial College Healthcare NHS Trust
Wellcome Trust
The Magdi Yacoub Institute
Foundation for Circulatory Health
Elision Health Limited
Foundation for Circulatory Health
The Royal Society
Foundation for Circulatory Health
Academy of Medical Royal Colleges
Imperial College Healthcare NHS Trust
Foundation for Circulatory Health
The Leverhulme Trust
University of London Central Research Funds
British Heart Foundation
British Heart Foundation
British Heart Foundation
Pfizer Limited
Astra Hassle Ab
British Heart Foundation
GlaxoSmithKline Services Unlimited
British Heart Foundation
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: 642458
RE/08/002/23906
Order No. 75195/ICAM10 (IC)
GG14/1022
100023/Z/12/Z
S'ship Agreement: A Wheelock
RDOTH 79560
EP/I001700/1
BB/I00534X/1
092855/Z/10/Z
Award Reference P42582
5117/R20R
Fund 7071 Mr J. Wolfe Vascular
n/a
EP/K503381/1
083689/Z/07/B
RD410
UK00006
None
083662/Z/07/Z
HSC269/10
ICCH/10/5030
None Given
ICCH/06/5011
2007/R3-IJP
ICCH/07/5014
None Given
N/A
ICCH/07/5015
F/07 058/AA
N/A
PG/04/078/17370
PG/04/078/17370
FS/03/119/16285
236350
SH-AHM-0029
PG/03/141/16238
s2624
PG/2001087
RDB05 79560
Keywords: Science & Technology
Technology
Engineering, Biomedical
Engineering
Aortic root replacement
Patient-specific modelling
Phase-contrast MRI
Helical flow
Wall shear stress
Computational fluid dynamics
COMPUTATIONAL FLUID-DYNAMICS
WALL SHEAR-STRESS
FLOW PATTERNS
BLOOD-FLOW
VOLUNTEERS
ARCH
Aortic root replacement
Computational fluid dynamics
Helical flow
Patient-specific modelling
Phase-contrast MRI
Wall shear stress
Aged
Aorta
Aortic Valve
Blood Flow Velocity
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
Humans
Magnetic Resonance Angiography
Male
Middle Aged
Aorta
Aortic Valve
Humans
Magnetic Resonance Angiography
Blood Flow Velocity
Heart Valve Prosthesis Implantation
Heart Valve Prosthesis
Aged
Middle Aged
Male
Biomedical Engineering
09 Engineering
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2015-09-14
Appears in Collections:Department of Surgery and Cancer
Institute of Clinical Sciences
Chemical Engineering
Faculty of Medicine
Faculty of Engineering