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A kit-based aluminium-[F-18]fluoride approach to radiolabelled microbubbles
| File | Description | Size | Format | |
|---|---|---|---|---|
 d1cc04790f.pdf | Published version | 2.2 MB | Adobe PDF | View/Open |
| Title: | A kit-based aluminium-[F-18]fluoride approach to radiolabelled microbubbles |
| Authors: | Teh, JH Braga, M Allott, L Barnes, C Hernandez-Gil, J Tang, M-X Aboagye, EO Long, NJ |
| Item Type: | Journal Article |
| Abstract: | The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40–50% RCY), which was incorporated into MBs (40–50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting. |
| Issue Date: | 15-Oct-2021 |
| Date of Acceptance: | 15-Oct-2021 |
| URI: | http://hdl.handle.net/10044/1/101072 |
| DOI: | 10.1039/d1cc04790f |
| ISSN: | 1359-7345 |
| Publisher: | Royal Society of Chemistry |
| Start Page: | 11677 |
| End Page: | 11680 |
| Journal / Book Title: | Chemical Communications |
| Volume: | 57 |
| Issue: | 88 |
| Copyright Statement: | © The Royal Society of Chemistry 2021. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| Publication Status: | Published |
| Online Publication Date: | 2021-10-15 |
| Appears in Collections: | Bioengineering Department of Surgery and Cancer Chemistry Catalysis and Advanced Materials Faculty of Medicine Faculty of Natural Sciences |
This item is licensed under a Creative Commons License
