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Preterm brain injury and neurodevelopmental outcomes: a meta-analysis
File | Description | Size | Format | |
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peds_2022057442.pdf | Published version | 1.98 MB | Adobe PDF | View/Open |
Title: | Preterm brain injury and neurodevelopmental outcomes: a meta-analysis |
Authors: | Rees, P Callan, C Chadda, K Vaal, M Diviney, J Sabti, S Harnden, F Gardiner, J Battersby, C Gale, C Sutcliffe, A |
Item Type: | Journal Article |
Abstract: | Context: Preterm brain injuries are common; neurodevelopmental outcomes following contemporary neonatal care are continually evolving. Objective: To systematically review and meta-analyze neurodevelopmental outcomes among preterm infants after intraventricular hemorrhage (IVH) and white matter injury (WMI). Data Sources: Published and grey literature were searched across 10 databases between 2000-2021 Study Selection: Observational studies reporting 3-year neurodevelopmental outcomes for preterm infants with IVH or WMI compared to preterm infants without injury. Data extraction: Study characteristics, population characteristics, and outcome data were extracted. Results: 38 studies were included. There was an increased adjusted risk of moderate-severe neurodevelopmental impairment after IVH grade 1-2 (aOR 1.35 [95% CI 1.05, 1.75]) and IVH grade 3-4 (aOR 4.26 [3.25, 5.59]). Children with IVH grade 1-2 had higher risks of cerebral palsy (OR 1.76 [1.39, 2.24)], cognitive (OR 1.79 [1.09, 2.95]), hearing (OR 1.83 CI [1.03. 3.24]), and visual impairment (OR 1.77 [1.08, 2.9]). Children with IVH grade 3-4 had markedly higher risks of cerebral palsy (OR 4.98 [4.13, 6.00)], motor (OR 2.7 [1.52, 4.8)], cognitive (OR 2.3 [1.67, 3.15)], hearing (OR 2.44 [1.42, 4.2)), and visual impairment (OR 5.42 [2.77, 10.58)). Children with WMI had much higher risks of cerebral palsy (OR 14.91 [7.3, 30.46), motor (OR 5.3 [3, 9.36)], and cognitive impairment (OR 3.48 [2.18, 5.53)). Limitations: Heterogeneity of outcome data. Conclusions: Mild IVH, severe IVH, and WMI are associated with adverse neurodevelopmental outcomes. Utilization of core outcomes sets and availability of open-access study data would improve our understanding of the nuances of these outcomes. |
Issue Date: | 4-Nov-2022 |
Date of Acceptance: | 8-Jul-2022 |
URI: | http://hdl.handle.net/10044/1/99795 |
DOI: | 10.1542/peds.2022-057442 |
ISSN: | 0031-4005 |
Publisher: | American Academy of Pediatrics |
Start Page: | 1 |
End Page: | 15 |
Journal / Book Title: | Pediatrics |
Volume: | 150 |
Issue: | 6 |
Copyright Statement: | © 2022 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License . |
Publication Status: | Published |
Online Publication Date: | 2022-11-04 |
Appears in Collections: | Faculty of Medicine School of Public Health |
This item is licensed under a Creative Commons License