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Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.pdf | Published version | 443.54 kB | Adobe PDF | View/Open |
Title: | Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery |
Authors: | Ahmed, WUR Bhatia, S McLean, KA Khaw, R Baker, D Kamarajah, SK Bell, S Nepogodiev, D Harrison, EM Glasbey, JC Borakati, A Burke, J Drake, TM Bath, MF Claireaux, HA Gundogan, B Mohan, M Deekonda, P Kong, C Joyce, H McNamee, L Woin, E Khatri, C Fitzgerald, JE Bhangu, A Arulkumaran, N Duthie, F Hughes, J Pinkney, TD Prowle, J Richards, T Thomas, M Blanco-Colino, R Chapman, SJ Pata, F Pellino, G Sgro, A Soares, A Van Elst, T Van Straten, S Knowles, CH Dynes, K Patel, M Patel, P Wigley, C Suresh, R Shaw, A Klimach, S Jull, P Evans, D Preece, R Ibrahim, I Manikavasagar, V Smith, R Brown, FS Teo, R Sim, DPY Logan, AE Barai, I Amin, H Suresh, S Sethi, R Gul, W Bolton, W Corbridge, O Horne, L Attalla, M Morley, R Robinson, C Hoskins, T McAllister, R Lee, S Dennis, Y Nixon, G Heywood, E Wilson, H Ng, L Samaraweera, S Mills, A Doherty, C Belchos, J Phan, V Lim, M Miller, FA Chouari, T Gardner, T Goergen, N Hayes, JDB MacLeod, CS McCormack, R McKinley, A McKinstry, S Milligan, W Ooi, L Rafiq, NM Sammut, T Sinclair, E Smith, M Wong, J Ablett, AD Tie-Gill, T Ramsay, G De Paola, L McGuckin, S Alshakhs, A Ahmeidat, A Francis, AA Baker, C Boulton, APR Collins, J Copley, HC Fearnhead, N Fox, H Mah, T McKenna, J Naruka, V Nigam, N Nourallah, B Perera, S Qureshi, A Saggar, S Sun, L Wang, X Yang, DD Ali, Z Mullarkey, L Walshe, R Lewis, E Berry, B Moneim, J Mookerjee, S Al-hadithi, A Caroll, P Doyle, C Elangovan, S Falamarzi, A Perai, KG Greenan, E Jain, D Lang-Orsini, M Lim, S Ridgway, P Van der Laan, S Arthur, J Barclay, J Bradley, P Edwin, C Finch, E Hayashi, E Hopkins, M Kelly, D Kelly, M McCartan, N Ormrod, A Pakenham, A Christy, S Hayward, J Hitchen, C Kishore, A Martins, T Philomen, J Rao, R Rickards, C Burns, N Copeland, M Durand, C Dyal, A Ghaffar, A Gidwani, A Grant, M Gribbon, C Gruhn, A Leer, M Ojofeitimi, O Carroll, L Hylands, A Delaugere, LP Reveendran, D Ahmad, K Beattie, G Beatty, M Campbell, G Donaldson, G Graham, S Holmes, D Kanabar, S Liu, H McCann, C Stewart, R Vara, S Coulter, C Ralston, C Laverty, L Gallagher, P Ajibola-Taylor, O Andah, EJE Ani, C Cabdi, NMO Ito, G Jones, M Komoriyama, A Titu, L Ahmed, A Yeo, YQ Elliott, D Bennett, J Mcnamara, M Sivarajah, S Dunmore, C Basra, M Gallogly, P Harinath, G Leong, SH Pradhan, A Siddiqui, I Zaat, S Ali, A Galea, M Looi, WL Ng, JCK Farhan-Alanie, MMH Aitken, G Nair, M Aly, MH Buari, M Atkin, G Azizi, A Cargill, Z China, Z Elliot, J Jebakumar, R Lam, J Mudalige, G Onyerindu, C Renju, M Babu, VS Ahmed, K Sheikh, Z Monks, M Lehmann, J Rotimi, O Hussain, M Joji, N Lovett, B Mownah, H Dwyer-Hemmings, L Busuttil, A Powell, J Hensher, C Vivian, F Ali, B Cresswell, B Dhillon, AK Dupaguntla, YS Hungwe, C Lowe-Zinola, JD Tsang, JCH Wcislo, K Bevan, K Cardus, C Duggal, A Hossain, S McHugh, M Scott, M Millar, Z Hirosue, S Ogunmwonyi, I Nakakande, D Chan, F Evans, R Gurung, E Haughey, B Jacob-Ramsdale, B Kerr, M Lee, J McCann, E Reid, N Kwek, I Gaze, H Nirmalanantha, A Bin Amran, MA Foulkes, A Jones, N Lau, ISF Hayat, F Hodgson, S Johnston, R Jones, W Khan, M Linn, T Long, S Seetharam, P Shaman, S Smart, B Pillai, S Khoury, G Powell, T Maleyko, I Sangheli, A Ransome, M Isse, M Aromolaran, O Bholah, H Anilkumar, A Davies, J Griffith, J Hughes, B Islam, Y Kidanu, D Mushaini, N Qamar, I Robinson, H Schramm, M Tan, CY Murray, V Theocharidou, L Malik, T Janmohamed, I Carhart, B Khan, A Apperley, H Billyard, C Blazeby, JM Cannon, SP Carse, S Gopfert, A Loizidou, A Parkin, J Sanders, E Sharma, S Slade, G Telfer, R Huppatz, IW Worley, E Asif, A Hullait, R Quinn, P Rylance, A Butt, S Leathes, J Chandramoorthy, L Friend, C Harris, L Jain, P Karim, MJ Killington, K McGillicuddy, J Rafferty, C Rahunathan, N Rayne, T Varathan, Y Verma, N Zanichelli, D Arneill, M Brown, F Campbell, B Crozier, L Henry, J McCusker, C Prabakaran, P Wilson, R Karelia, S Clements, JM Rainey, M Asif, U Connor, M Dindyal, S Math, N Pagarkar, A Saleem, H Seth, I Standfield, N Swartbol, T Adamson, R Choi, JE El Tokhy, O Ho, W Javaid, NR Mehdi, AS Menon, D Plumptre, I Sturrock, S Turner, J Warren, O Joshi, N Rahman, A Gallagher, M Crane, E Ferris, B Gadsby, C Smallwood, J Vipond, M Wilson, V Amarnath, T Doshi, A Gregory, C Kandiah, K Powell, B Spoor, H Toh, C Vizor, R Rebuffa, N Abdelgalil, R Lai, RSY Smith, E Common, M Dunleavy, K Harris, S Luo, C Mesbah, Z Kumar, AP Redmond, A Skulsky, S Walsh, T Daly, D Deery, L Epanomeritakis, E Harty, M Kane, D Khan, K Mackey, R McConville, J McGinnity, K Wong, HL Ang, A Kee, JY Leung, E Norman, S Palaniappan, S Sarathy, PP Yeoh, T Frost, J Hazeldine, P Jones, L Karbowiak, M Macdonald, C Mutarambirwa, A Omotade, A Runkel, M Ryan, G Sawers, N Searle, C Vig, S Hlukha, L Pike, G Kamel, F Thakkar, R McAuliffe, O Ahmad, A McGartland, R Sim, R Song, A Wayman, J Brown, R Chang, LH Concannon, K Crilly, C Arnold, TJ Burgin, A Cadden, F Choy, CH Coleman, M Lim, D Luk, J Mahankali-Rao, P Prudence-Taylor, AJ Ramakrishnan, D Russell, J Fawole, A Gohil, J Green, B Hussain, A McMenamin, L Tang, M Azmi, F Benchetrit, S Cope, T Haque, A Harlinska, A Holdsworth, R Ivo, T Martin, J Nisar, T Patel, A Sasapu, K Trevett, J Vernet, G Aamir, A Bird, C Durham-Hall, A Gibson, W Hartley, J May, N Maynard, V Goble, M Downs, E Wheldon, L Baggus, E Mandal, A Nayeem, A Ahmed, S Fradley, W Johnson, S Wood, CM Orbell, J Stringfellow, TD Tenters, F Tresidder, S Wilson, C Gallagher, S Criswell, T Ward, J Mukkavilli, A Stubbs, B Fordyce, W Cheung, W Grant, A Tod, N Tew, ZY Suchdev, N Lim, SW Bews-Hair, M Lim, ZH Lim, SW Vella-Baldacchino, M Auckburally, S Chopada, A Easdon, S Goodson, R McCurdie, F Narouz, M Radford, A Rea, E Taylor, O Yu, T Sookramanien, SR Chan, A Bointas, G Alfa-Wali, M Amani, L Auluck, I Bruce, P Emberton, J Kumar, R Lagzouli, N Mehta, A Murtaza, A Raja, M Dennahy, IS Frew, K Given, A He, YY Karim, MA MacDonald, E McDonald, E McVinnie, D Ng, SK Pettit, A Berthaume-Hawkins, SD Charnley, R Fenton, K Jones, D Murphy, C Ng, JQ Reehal, R Seraj, SS Shang, E Tonks, A White, P Yeo, A Paul, M Ward, KL Bagnall, M Chong, P Gabriel, R Patel, N Richardson, E Symons, L Aubrey-Jones, D Dawood, S Dobrzynska, M Faulkner, S Griffiths, H Mahmood, F Perry, M Power, A Simpson, R Pherwani, SA Wang, K Mitchell, L Heyworth, J Ayyar, S Brobbey, P Burrows, A Elder, P Ganyani, R Horseman, C Hurst, P Mann, H Marimuthu, K McBride, S Pilsworth, E Powers, N Stanier, P Obukofe, R Polson, R Mason, D Mackenzie, E Innes, R Kersey, T Kopczynska, M Langasco, N Rajagopal, R Russell, C Doyle, N Habib, Z Zardab, M Sartaj, F Farooq, H Tabibi, M Imam, L Atkins, B Beasley, W Lim, ZC Gill, A Li Ang, H Williams, H Yogeswara, T Drury, DJ James, SJ Barnett, R Teasdale, AB Richardson, ETJ Thomas, DA Williams, RL Najabat-Lattif, HF Akram, B Carter, R Fam, M Fong, J Latter, J Long, M Mackinnon, S McKenzie, C Osmanska, J Raghuvir, V Shafi, A Tsang, K Walker, L Cahya, E Lou, G Coyle, M Homyer, K Zhu, LY Woods, M Bountra, K Coldicutt, O Fletcher, D Hudson, S Iqbal, S Bernal, TL Martin, JWB Moss-Lawton, F Suchett-Kay, I Chang, J Suchett-Kaye, I Mihailidis, TH Cardwell, A Edgerton, K Laws, J Rai, A Robinson, K Waite, K Youssef, H Alawattegama, H Seite, E Barrett, A Riordan, E Lam, W Dowdeswell, M Mulvenna, C Knight, C Koo, PY Lazarou, A Stanger, S Thorn, C Triniman, MC Netke, T Awokoya, O Gurowich, L Dhera, K Hossaini, S Botha, A Boyles, L Cumming, S Deepak, S Ezzat, A Fowler, AJ Gwozdz, AM Hussain, SF Khan, S Li, H Morrell, BL Neville, J Nitiahpapand, R Pickering, O Sagoo, H Sharma, E Welsh, K Williams, L Hayat, S Tincknell, L Spazzapan, M Teeling, F Sysum, K Denley, S Latter, M Agarwal, M Al-Saadi, N Bhambra, R Gupta, A Jawad, ZAR Jiao, LR Mahir, G Singagireson, S Thoms, BL Tseu, B Wei, R Yang, N Britton, N Leinhardt, D Mahfooz, M Palkhi, A Price, M Sheikh, S Barker, M Bowley, D Cant, M Datta, U Farooqi, M Lee, A Morley, G Amin, MN Parry, A Patel, S Strang, S Yoganayagam, N Guruswamy, M Beedham, W Brazier, E Elghobashy, M Bajaj, M Etel, E Adlan, A Chandramoorthy, S Choudhary, Y Das, K Feldman, M France, B Grace, R Puddy, H Soor, P Kisiel, A Woodmass, M Hayden, H Ali, Y Husain, S Ali, M Dhillon, P Faraj, A Gerard, L Glover, M Imran, H Kim, S Patrick, Y Peto, J Prabhudesai, A Tang, A Vadgama, N Dhaliwal, R Ecclestone, T Harris, A Ong, D Patel, D Philp, C Stewart, E Wang, L Wong, E Xu, Y Ashaye, T Fozard, T Galloway, F Kaptanis, S Mistry, P Nguyen, T Olagbaiye, F Osman, M Philip, Z Rembacken, R Tayeh, S Theodoropoulou, K Liu, FY Arnold, A Pedersen, AC Cunha, P Ahmed, M Al Zawawi, S Kudva, V Herman, A Lau, J Saha, A Trotter, M Miscampbell, M Robinson, A Johnston, J Dharni, A Lamb, S Westerman, T Adeleye, O Cave, D Gunwa, T Magalhaes, J Makwana, S Mason, R Parish, M Regan, H Renwick, P Roberts, G Salekin, D Sivakumar, C Tariq, A Liew, I McDade, A Stewart, D Evans, E Campbell, L Gillespie, M Cheong, CM Hague, M Hudson-Peacock, N Jackson, CES James, F Pitt, J Walker, EY Kulathevanayagam, K Varghese, A Ike, SI Aftab, R Ang, JJ Anwar, S Battle, J Budd, E Chui, J Crook, H Davies, P Easby, S Hackney, E Ho, B Imam, SZ Rammell, J Chu, TSM Baljer, B Mogg, JAW Rai, P Andrews, H Perry, C Schinle, P Ahmed, P Aquilina, T Balai, E Church, M Cumber, E Curtis, A Davies, G Dumann, E Greenhalgh, S Kim, P King, S Metcalfe, KHM Passby, L Redgrave, N Soonawalla, Z Waters, S Zornoza, A Claireaux, H Williams, M Smillie, R Goetz, J Appleby, E Fadipe, T Vaughan-Burleigh, S Davies, R Gulzar, I Hole, J Hull, K Ishaq, H Karaj, J Kelkar, A Love, E Thakrar, D Vine, M Waterman, A James, P Puri, G Hussain, P Flather, R Cutler, A Pathak, S Sheldon, J Collicott, T Al-Ausi, M Ko, M Dib, NP Francis, N Hanson, M Ingleton, R Sadanand, KS Sukirthan, N Mondal, A Jovaisaite, A Shah, SM Khalid, N Gutmann, D Davison, S Alame, YJ Syed, L Owen, WJ Arnell, S Ball, M Bassam, N Beghal, G Chang, A Dawe, V George, A Huq, T Ikram, B Kanapeckaite, L Ramjas, D Rushd, A Sait, S Serry, M Yardimci, E Kalderon, R Ahsan, SD Anthony-Uzoeto, U Hall, CM Zheng, S Wynter, K Capella, S Chenciner, L Episkopos, C Karam, E McCarthy, C Moore-Kelly, W Watson, N Nadama, HH James, C Sapre, D Ghosh, R Baird, J Cockburn, L Blackwood, O Simpson, W Ahluwalia, V Barnfield, J Ben-Gal, O Bloom, I Gharatya, A Khodatars, K Merchant, N Moonan, A Moore, M Patel, K Spiers, H Sundaram, K Jeong, S Bishop, S Black, J Chadwick, H Huisman, L Ingram, H Martin, L Metcalfe, M Sangal, P Seehra, J Thatcher, A Venturini, S Whitcroft, I Bate, R Hobson, C Adam, AH Redclift, C Do, J Poli, F Batterham, A Brown, S Pandya, A Afzal, Z Gani, A Gomaa, A Hussein, N Oh, SY Pazhaniappan, N Sharkey, E Sivagnanasithiyar, T Williams, C Yeung, J Parekh, JN Clay, W Pieri, K Jackson, A Saxena, A Gurung, B Oyebola, T Reilly, S Cruddas, L Gurjar, S Pau, A Prakash, R Randhawa, R Djeugam, B Gardezi, S Ul-Hasan, S Martin-Hernandez, MP Sisley, M Modi, S Antakia, R Archer, J Chen, L Eiben, I Naylor, M Osei-Bordom, D Trenear, R Bannard-Smith, J Griffiths, N Patel, BY Saeed, F Al-Saraff, Z Elbayouk, A Soh, YJ Mather, J Yusuf, Z Al-Sarraf, Z Naja, M Rassool, SB Convill, J Auty, C Abdikadir, H Bennett, M Church, R Clements, SE Court, J Delvi, A Hubert, J Macdonald, B Mansour, F Patel, RR Perris, R Small, S Tam, JPH Nikookam, Y Warsame, A Pace, C Kiandee, M Ridwan, R Carey, C Hirri, F Betts, A Brown, N Chong, A Croitoru, C Grey, A Hickland, P Ho, C Hollington, D McKie, L Nelson, AR Stewart, H Eiben, P Nedham, M Ali, I Brown, T Hunt, C Joyner, C McAlinden, C Roberts, J Rogers, D Thachettu, A Tyson, N Vaughan, R Yasin, T Powell-Chandler, A McMillan, MJA Ling, JJ Pendelbury, L Kerimzade, K Howard, EO Humayun, S Wadsworth, OJ Roche, CD Andrew, K Bhamra, N Leong, S Mistry, R Noble, H Rashed, F Walker, NR Watson, L Worsfold, M Yarham, E Wood, F Arshad, A Barmayehvar, B Cato, L Chan-lam, N Do, V Leong, A Zheleniakova, T Tan, K Abdelhameed, F Haglund, C Radnaeva, I Hu, N Rambhatla, S Waldron, D Madahar, P Malik, S Coppel, J Hussain, ST Mahmood, R Nourzaie, R Sheik-Ali, S Thomas, A Alagappan, A Ashour, R Bains, H Diamond, J Gordon, J Ibrahim, B Khalil, M Mittapalli, D Neo, YN Patil, P Peck, FS Reza, N Swan, I Whyte, M Campbell, A Meney, LC Kang, CK Chiu, JZJ Livie, V Livie, J Chaudhry, S Hernon, J Khawar, H Pullinger, M Rothnie, K Ujjal, S Gorgievska, REBECCA Pooley, G Shishkin, B Gorgievska, R Docherty, J Southgate, A Coomes, A Chaudhry, FA Bhatte, S Curtis, J Green, S Mayer, A Watkinson, G Ragavoodoo, A Mercer, L Mercer, C Chapple, K Hawthorne, T Khaliq, M Majkowski, L Malik, TAM Mclauchlan, K En, BNW Parton, S Robinson, SD Saat, M Shurovi, BN Varatharasasingam, K Ward, AE Behranwala, K Bertelli, M Cohen, J Duff, F Fafemi, O Gupta, R Manimaran, M Mayhew, J Peprah, D Wong, MHY Morice, O Burzic, A Cheung, J Shashidhara, A Theodoraki, G Birk, J Ong, A Farmer, N Houghton, C Kandhari, N Ladha, D Mayes, J McLennan, F Panahi, P Seehra, H Agrawal, R Ahmed, I Ali, S Birkinshaw, F Choudhry, M Gokani, S Harrogate, S Jamal, S Nawrozzadeh, F Swaray, A Szczap, A Warusavitarne, J Abdalla, M Asemota, N Cullum, R Hartley, M Maxwell-Armstrong, C Phillips, J Yule, A Ahmed, L Clement, KD Craig, N Elseedawy, E Gorman, D Kane, L Moss, E Naasan, A Ravi, F Shields, P Zhu, Y Palmer, C Melaugh, T Hall, JD Kouli, O Hassane, AS Azhar, AW Tan, TK Archer, M Cobley, H Dennis, R Downes, C Guevel, B Lamptey, E Murray, H Radhakrishnan, A Saravanabavan, S Sardar, M Shaw, C Tilliridou, V Wright, R Ye, W Davidson, K Perchard, W Scurr, T Campbell, E Kelk, L Ghosh, A Gibbins, A Mala, D Alturki, N Helliwell, R Jones, E Lambotharan, S Scott, K Sivakumar, R Victor, L Hall, O Mecia, L Hew, C Varathan, K Tong, L Chandrasekar, B Boraluwe-Rallage, H Froggatt, P Haynes, S Hung, YMA Keyte, A Matthews, L Haray, P John, I Mathivanan, A Morgan, L Oji, O Okorocha, C Rutherford, A Stageman, N Tsui, A Whitham, R Giacci, L Buchanan, E Kwak, SY Ong, EH Gardner, S Lim, J Maden, C Illahi, M Amoah-Arko, A Cecil, E Dietrich, A Fitzpatrick, H Guy, C Hair, J Hilton, J Jawad, L McAleer, E Taylor, Z Yap, J Hale, J Tan, ZX Edwards, S Akhbari, M Debnath, D Dhir, T Elbuzidi, M Elsaddig, M Glace, S Khawaja, H Koshy, R Lal, K Lobo, L McDermott, A Meredith, J Qamar, MA Vaidya, A Acquaah, F Barfi, L Carter, N Gnanappiragasam, D Ji, C Kaminski, F Lawday, S Mackay, K Sulaiman, SK Webb, R Ananthavarathan, P Dalal, F Farrar, E Hashemi, R Hossain, M Jiang, J Lex, J Mason, L Matthews, JH McGeorge, E Modhwadia, S Pinkney, T Radotra, A Rickard, L Rodman, L Sales, A Tan, KL Stahl, R Stahl, J Hickman, A Collett, D Goolam-Mahomed, Z Allen, B Atiyah, A Ahmad, H Jones, J Bachi, A Bajwa, DS Brown, LR Butler, A Calciu, A Davies, E Gardner, I Girdlestone, T Ikogho, O Keelan, G Tam, J Elias, J Ngaage, M Thompson, J Bristow, S Brock, E Davis, H Pantelidou, M Sathiyakeerthy, A Singh, K Gan, FW McGregor, O Ogundiya, E Boulbadaoui, A Kirnon-Jackman, O Ntakomyti, E Chaudhry, A Dickson, G Glen, P Gregoriou, K Hamid, H Mclean, A Mehtaji, P Neophytou, G Potts, S Lim, QX Peckham, H Yong, SQ Chen, JY Siva, S Sam, ZH Gilani, M Belgaid, DR Durno, J Ghailan, N Henshaw, V Nazir, UR Omar, I Riley, BJ Smart, G Van Winsen, K Makin-Taylor, R Goh, YN Muthukumar, MG Phillips, S Tjoakarfa, J Giri, A Suresan, S Bhatti, A Chan, M Keshvala, C Michaelidou, M Simmonds, L Smith, C Wimalathasan, A Hey, CY Thavayogan, R Thomas, P Johnson, TA Williams, R Rashid, A Kushairi, A Rais, A Diallo, R Abbas, J Cairns, C Chin, YR Connelly, A Moug, S Nair, A Svolkinas, D Bradley, E McTiernan, M Macdonald, S Sharkey, S McLaughlin, N Amey, C Kraria, L Coe, P Subar, D Wang, H Zaver, V Brayley, J Cookson, P Cunningham, L Gaukroger, A Ho, M Hough, A King, J Widdison, A Brown, B Chavan, A Francis, S Hare, L Lund, J Malone, N Mavi, B McIlwaine, A Rangarajan, S Jegatheeswaran, L Madhavan, A Warne, M Malcolm, FL Lessware, T Wilkerson, HT Chatterjee-Woolman, S Wright, J Abuhussein, N Campbell, HS Daniels, J Fitzgerald, I Mansfield, S Pendrill, A Robertson, D Smart, YW Teng, T Yates, J Yoong, A Longshaw, A Flannery, O Green, R Leaning, M Cragg, J Sharriff, H Belgaumkar, A Katira, A Kossoff, J Kukran, S Laing, C Mathew, B Mohamed, T Myers, S Novell, R Phillips, BL Turlejski, T Turner, S Varcada, M Warren, L Wynell-Mayow, W Linley-Adams, L Osborn, G Saunders, M Spencer, R Srikanthan, M Tailor, S Tullett, A Ganesananthan, S Kwan, KWL Sanders-Crook, L Al-Masri, S Carr, G Ebhogiaye, O Heng, S Manivannan, S Manley, J McMillan, LE Peat, C Phillips, B Thomas, S Whewell, H Williams, G Bienias, A Cope, EA Courquin, GR Day, L Garner, C Gimson, A Harris, C Markham, K Moore, T Nadin, T Phillips, C Subratty, SM Eames, S Lewis, F Brown, K Dada, J Durbacz, M Filipescu, T Harrison, E Kennedy, ED Khoo, E Kremel, D Lyell, I Pronin, S Tummon, R Ventre, C Walls, L Wootton, E Akhtar, A El-Sawy, D Farooq, M Gaddah, M Katsaiti, I Khadem, N Leong, K Williams, I Masiha, E Chean, CS Chudek, D Desai, H Ellerby, N Hammad, A Malla, S Murphy, B Oshin, O Popova, P Rana, S Ward, T Abbott, TEF Akpenyi, O Edozie, F El Matary, R English, W Jeyabaladevan, S 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Sanchez, MJ Martin-Borregon, P Quevedo, A Martinez, J Marin, JM Rodriguez, P Esteban Avendano, I Jimenez Relimpio, C Lancho Lavilla, P Bartolome, IB Gomez Cano, I Blasco Andres, C Abad-Motos, A Marinez-Hurtado, E Salvachua-Fernandez, R Muniesa, C Avelino, L Cholewa, H Sancho-Muriel, J Navasquillo, M Navio, A Abello, D De Jesus, M Alvarez, E Kefleyesus, A Bugmann, A Piotet, LM Tonchev, P Tamosiunas, A Rottier, SJ Negoi, I Bernado, IR Eftychiou, S |
Item Type: | Journal Article |
Abstract: | Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK). |
Issue Date: | 6-Jan-2022 |
Date of Acceptance: | 20-Dec-2021 |
URI: | http://hdl.handle.net/10044/1/99576 |
DOI: | 10.1093/bjsopen/zrab150 |
ISSN: | 2474-9842 |
Publisher: | Oxford University Press |
Journal / Book Title: | BJS Open |
Volume: | 6 |
Issue: | 1 |
Copyright Statement: | © The Author(s) 2022. Published by Oxford University Press on behalf of BJS Society Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
Keywords: | Science & Technology Life Sciences & Biomedicine Surgery MORTALITY Acute Kidney Injury Cohort Studies Digestive System Surgical Procedures Humans Kidney Postoperative Complications Prognosis Prospective Studies Retrospective Studies Risk Assessment Risk Factors STARSurg Collaborative and EuroSurg Collaborative Kidney Humans Postoperative Complications Prognosis Digestive System Surgical Procedures Risk Assessment Risk Factors Retrospective Studies Cohort Studies Prospective Studies Acute Kidney Injury Science & Technology Life Sciences & Biomedicine Surgery MORTALITY |
Publication Status: | Published |
Article Number: | ARTN zrab150 |
Appears in Collections: | Department of Surgery and Cancer |
This item is licensed under a Creative Commons License