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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
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 Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures an international cohort study.pdf | Published version | 516.26 kB | Adobe PDF | View/Open |
| Title: | Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study |
| Authors: | Khatri, C Ward, AE Nepogodiev, D Ahmed, I Chaudhry, D Dhaif, F Bankhad-Kendall, B Kaafarani, H Bretherton, C Mahmood, A Marais, L Parsons, N Bhangu, A Metcalfe, A Parsons, N Khatri, C Siaw-Acheampong, K Chaudhry, D Dawson, BE Evans, JP Glasbey, JC Gujjuri, RR Heritage, E Jones, CS Kamarajah, SK Khatri, C Keatley, JM Lawday, S Li, E Mckay, SC Nepogodiev, D Pellino, G Tiwari, A Simoes, JFF Trout, IM Venn, ML Wilkin, RJW Bhangu, A Ademuyiwa, AO Agarwal, A Al Ameer, E Alderson, D Alser, O Arnaud, AP Augestad, KM Bankhead-Kendall, B Benson, RA Chakrabortee, S Blanco-Colino, R Brar, A Bravo, AM Breen, KA Buarque, IL Caruana, E Cunha, MF Davidson, GH Desai, A Di Saverio, S Edwards, J Elhadi, M Farik, S Fiore, M Fitzgerald, JE Ford, S Gallo, G Ghosh, D Gomes, GMA Griffiths, E Halkias, C Harrison, EM Hutchinson, P Isik, A Kaafarani, H Kolias, A Lawani, I Lederhuber, H Leventoglu, S Loffler, MW Martin, J Mashbari, H Mazingi, D Mohan, H Moore, R Moszkowicz, D Ng-Kamstra, JS Metallidis, S Moug, S Niquen, M Ntirenganya, F Outani, O Pata, F Pinkney, TD Pockney, P Radenkovic, D Ramos-De la Medina, A Roberts, K Santos, I Schache, A Schnitzbauer, A Stewart, GD Shaw, R Shu, S Soreide, K Spinelli, A Sundar, S Tabiri, S Townend, P Tsoulfas, G Van Ramshorst, G Vidya, R Vimalachandran, D Wright, N Simoes, JFF Mak, JKC Kulkarni, R Sharma, N Nankivell, P Tirotta, F Parente, A Breik, O Kisiel, A Cato, LD Saeed, S Bhangu, A Griffiths, E Pathanki, AM Ford, S Desai, A Almond, M Kamal, M Chebaro, A Lecolle, K Truant, S El Amrani, M Zerbib, P Pruvot, FR Mathieu, D Surmei, E Mattei, L Marin, H Dudek, J Singhal, T El-Hasani, S Nehra, D Walters, A Cuschieri, J Davidson, GH Ho, M Wade, RG Johnstone, J Bourke, G Brunelli, A Elkadi, H Otify, M Pompili, C Burke, JR Bagouri, E Chowdhury, M Abual-Rub, Z Kaufmann, A Munot, S Lo, T Young, A Kowal, M Wall, J Peckham-Cooper, A Winter, SC Belcher, E Stavroulias, D Di Chiara, F Wallwork, K Qureishi, A Lami, M Sravanam, S Mastoridis, S Shah, K Chidambaram, S Smillie, R Shaw, A Bandyopadhyay, S Cernei, C Bretherton, C Jeyaretna, D Ganau, M Piper, RJ Duck, E Brown, S Jelley, C Tucker, SC Bond-Smith, G Griffin, XL Tebala, GD Neal, N Vatish, M Noton, TM Ghattaura, H Maher, M Fu, H Risk, OBF Majd, SH Sinha, S Shankar, S Aggarwal, A Kharkar, H Lakhoo, K Verberne, C Mastoridis, S Senent-Boza, A Sanchez-Arteaga, A Benitez-Linero, I Manresa-Manresa, F Tallon-Aguilar, L Melero-Cortes, L Fernandez-Marin, MR Duran-Munoz-Cruzado, VM Ramallo-Solis, I Beltran-Miranda, P Pareja-Ciuro, F Anton-Eguia, BT Dawson, AC Drane, A Oliva Mompean, F Gomez-Rosado, J Reguera-Rosal, J Valdes-Hernandez, J Capitan-Morales, L Del Toro Lopez, MD Patel, M Shabana, A Alanbuki, A Usman, O Tang, A Beamish, AJ Price, C Bosanquet, D Magowan, D Solari, F Williams, G Nassa, H Smith, L Elliott, L Mccabe, G Holroyd, D Jamieson, NB Mariani, NM Nicastro, V Li, Z Parkins, K Spencer, N Harries, R Egan, RJ Motter, D Jenvey, C Mahoney, R Fine, N Minto, T Henry, A Gill, C Dunne, N Sarma, DR Godbole, C Carlos, W Tewari, N Jeevan, D Naredla, P Khajuria, A Connolly, H Robertson, S Sweeney, C Di Taranto, G Shanbhag, S Dickson, K McEvoy, K Skillman, J Sait, M Al-omishy, H Baig, M Heer, B Lunevicius, R Sheel, ARG Sundhu, M Santini, AJA Fathelbab, MSAT Hussein, KMA Nunes, QM Jones, RP Shahzad, K Haq, I Baig, MMAS Hughes, JL Kattakayam, A Rajput, K Misra, N Shah, SB Clynch, AL Georgopoulou, N Sharples, HM Apampa, AA Nzenwa, IC Sud, A Podolsky, D Coleman, NL Callahan, MP Dunstan, M Beak, P Gerogiannis, I Ebrahim, A Alwadiya, A Goyal, A Phillips, A Bhalla, A Demetriou, C Grimley, E Theophilidou, E Ogden, E Malcolm, FL Davies-Jones, G Ng, JCK Mirza, M Hassan, M Elmaleh, N Daliya, P Williams, S Bateman, A Chia, Z A'Court, J Konarski, A Faulkner, G Talwar, R Patel, K Askari, A Jambulingam, PS Shaw, S Maity, A Hatzantonis, C Sagar, J Kudchadkar, S Cirocchi, N Chan, CH Eberbach, H Bayer, J Erdle, B Sandkamp, R Kaafarani, H Breen, K Bankhead-Kendall, B Alser, O Mashbari, H Velmahos, G Maurer, LR El Moheb, M Gaitanidis, A Naar, L Christensen, MA Kapoen, C Langeveld, K El Hechi, M Mokhtari, A Main, B Maccabe, T Newton, C Blencowe, NS Fudulu, DP Bhojwani, D Baquedano, M Caputo, M Rapetto, F Flannery, O Hassan, A Edwards, J Ward, A Tadross, D Majkowski, L Blundell, C Forlani, S Nair, R Guha, S Brown, SR Steele, C Kelty, CJ Newman, T Lee, M Chetty, G Lye, G Balasubramanian, SP Shah, SN Sherif, M Al-mukhtar, A Whitehall, E Giblin, A Wells, F Sharkey, A Adamec, A Madan, S Konsten, J Van Heinsbergen, M Sou, A Simpson, D Hamilton, E Blair, J Jimeno Fraile, J Morales-Garcia, D Carrillo-Rivas, M Toledo Martinez, E Pascual, A Landaluce-Olavarria, A Gonzalez De Miguel, M Gomez Cruzado, FL Begona, E Lecumberri, D Calvo Rey, A Prada Hervella, GM Dos Santos Carregal, L Rodriguez Fernandez, M Freijeiro, M El Drubi Vega, S Van den Eynde, J Oosterlinck, W Van den Eynde, R Sermon, A Boeckxstaens, A Cordonnier, A De Coster, J Jaekers, J Politis, C Miserez, M Galipienso Eri, M Garcia Montesino, JD Dellonder Frigole, J Noriego Munoz, D Lizzi, V Vovola, F Arminio, A Cotoia, A Sarni, AL Bekheit, M Kamera, BS Elhusseini, M Sharma, P Ahmeidat, A Gradinariu, G Cymes, W Hannah, A Mignot, G Shaikh, S Agilinko, J Sgro, A Rashid, MM Milne, K McIntyre, J Akhtar, MA Turnbull, A Brunt, A Stewart, KE Wilson, MSJ Rutherford, D McGivern, K Massie, E Duff, S Moura, F Brown, BC Khan, A Asaad, P Wadham, B Aneke, IA Collis, J Warburton, H Thomas, M Pearce, L Fountain, DM Laurente, R Sigamoney, K Dasa, M George, K Naqui, Z Galhoum, M Lipede, C Gabr, A Radhakrishnan, A Hasan, MT Kalenderov, R Pathmanaban, O Colombo, F Chelva, R Subba, K Abou-Foul, AK Khalefa, M Hossain, F Moores, T Pickering, L Shah, J Anthoney, J Emmerson, O Bevan, K Makin-Taylor, R Ong, CS Callan, R Bloom, O Vidya, R Chauhan, G Kaur, J Burahee, A Bleibleh, S Pigadas, N Snee, D Bhasin, S Crichton, A Habeebullah, A Bodla, AS Yassin, N Mondragon, M Dewan, V Giuffrida, MC Marano, A Palagi, S Grimaldi, DMS Testa, V Peluso, C Borghi, F Simonato, A Puppo, A D'Agruma, M Chiarpenello, R Pellegrino, L Maione, F Cianflocca, D Pruiti, C Giraudo, G Gelarda, E Dalmasso, E Abrate, A Daniele, A Ciriello, V Rosato, F Garnero, A Leotta, L Chiozza, M Anania, G Urbani, A Radica, KM Carcoforo, P Portinari, M Sibilla, M Archer, JE Odeh, A Siddaiah, N Baumber, R Parry, J Carmichael, H Velopulos, CG Wright, FL Urban, S McIntyre, JRC Schroeppel, TJ Hennessy, EA Dunn, J Zier, L Parmar, C Mccluney, S Shah, S Munoz Vives, JM Osorio, A Gomez Diaz, CJ Guariglia, CA Soto Montesinos, C Sanchon, L Xicola Martinez, M Guardia, N Collera, P Diaz Del Gobbo, R Sanchez Jimenez, R Farre Font, R Flores Clotet, R Brathwaite, CEM Liu, H Petrone, P Hakmi, H Sohail, AH Baltazar, G Heckburn, R Aujayeb, A Townshend, D McLarty, N Shenfine, A Jackson, K Johnson, C Madhvani, K Hampton, M Hormis, AP Young, R Miu, V Sheridan, K MacDonald, L Green, S Onos, L Dean, B Luney, C Myatt, R Williams, MA McVeigh, J Alqallaf, A Ben-Sassi, A Mohamed, I Mellor, K Joshi, P Joshi, Y Crichton, R Sonksen, J Aldridge, K Layton, GR Karki, B Jeong, H Pankhania, S Asher, S Folorunso, A Mistry, S Singh, B Winyard, J Mangwani, J Babu, BHB Liyanage, ASD Newman, S Blake, I Weerasinghe, C Ballabio, M Bisagni, P Longhi, M Armao, T Madonini, M Gagliano, A Pizzini, P Alga, A Nordberg, M Sandblom, G Jallad, S Lord, J Anderson, C El Kafsi, J Logishetty, K Saadya, A Midha, R Ip, M Ponniah, SH Stockdale, T Bacarese-Hamilton, T Foster, L James, A Anjarwalla, N Henriques, MD Hettige, R Baban, C Tenovici, A Salerno, G Hardie, J Page, S Anazor, F King, SD Luck, J Kazzaz, S HKruijff, S De Vries, JPPM Steinkamp, PJ Jonker, PKC Van der Plas, WY Bierman, W Janssen, Y Borgstein, ABJ Gisbertz, SS Henegouwen, VBM Enjuto, D Perez Gonzalez, M Diaz Pena, P Gonzalez, J Marqueta De Salas, M Martinez Pascual, P Rodriguez Gomez, L Garces Garcia, R Ramos Bonilla, A Herrera-Merino, N Fernandez Bernabe, P Cagigal Ortega, EP Hernandez, I De Castro Rubio, GE Cervera, I Kashora, F Siddique, MH Singh, A Barmpagianni, C Basgaran, A Basha, A Okechukwu, V Bartsch, A Gallagher, P Maqsood, A Sahnan, K Leo, CA Lewis, SE Ubhi, HK Exley, R Khan, U Shah, P Saxena, S Zafar, N Abdul-Jabar, H Mongelli, F Bernasconi, M Di Giuseppe, M Christoforidis, D La Regina, D Arigoni, M Liew, I Al-Sukaini, A Mediratta, S Saxena, D Brown, O Boal, M Dean, H Higgs, S Stanger, S Abdalaziz, H Constable, J Ishii, H Preece, R Dovell, G Reddy, GR Dehal, A Shah, HB Cross, GW Seyed-Safi, P Smart, YW Kuc, A Al-Yaseen, M Jayasankar, B Balasubramaniam, D Abdelsaid, K Mundkur, N Gallagher, B Hine, T Keeler, B Soulsby, RE Taylor, A Davies, E Ryska, O Raymond, T Rogers, S Tong, A Hawkin, P Kinnaman, G Meagher, A Sharma, I Holler, E Dunning, J Viswanath, Y Freystaetter, K Dixon, J Hadfield, JN Hilley, A Egglestone, A Smith, B Arkani, S Freedman, J Youssef, M Sreedharan, L Baskaran, D Shaikh, I Seebah, K Reid, J Watts, D Kouritas, V Chrastek, D Maryan, G Gill, DF Khatun, F Ranjit, S Parakh, J Sarodaya, V Daadipour, A Khalifa, M Bosch, KD Bashkirova, V Dvorkin, LS Kalidindi, VK Choudhry, A Marx, W Espino Segura-Illa, M Sanchez Aniceto, G Castano-Leon, AM Jimenez-Roldan, L Delgado Fernandez, J Perez Nunez, A Lagares, A Garcia Perez, D Santas, M Paredes, I Esteban Sinovas, O Moreno-Gomez, L Rubio, E Vega, V Vivas Lopez, A Labalde Martinez, M Garcia Villar, O Pelaez Torres, PM Garcia-Borda, J Ferrero Herrero, E Gomez, P Eiriz Fernandez, C Ojeda-Thies, C Pardo Garcia, JM Jones, WH Divecha, H Whelton, C Board, T Hardie, C Powell-Smith, E Alotaibi, M Maashi, A Zowgar, A Alsakkaf, M Izquierdo, O Ventura, D Castellanos, J Lara, A Escobar, D Arrieta, M Garcia de Cortazar, U Villamor Garcia, I Cioci, A Ruiz, G Allen, M Rakoczy, K Pavlis, W Saberi, R Sobti, A Khaleel, A Unnithan, A Memon, K Bhaskar, PRR Maqboul, F Kamel, F Al-Samaraee, A Madani, R Kumar, L Nisar, P Agrawal, S Llaquet Bayo, H Duchateau, N De Gheldere, C Martin, J Cheng, D Yang, H Fayad, A Wood, ML Persad, A Groot, G Pham, H Hakami, I Boeker, C Mall, J Smith, H Haugstvedt, AF Jonsson, M Caja Vivancos, P Villalabeitia Ateca, I Prieto Calvo, M Marin, H Martin Playa, P Gainza, A Aragon Achig, EJ Rodriguez Fraga, A Melchor Corcostegui, I Mallabiabarrena Ormaechea, G Garcia Gutierrez, JJ Barbier, L Pesantez Peralta, MA Jimenez Jimenez, M Municio Martin, JA Gomez Suarez, J Garcia Opere, G Pascua Gomez, LA Onate Aguirre, M Fernandez-Colorado, A De la Rosa-Estadella, M Gasulla-Rodriguez, A Serrano-Martin, M Peig-Font, A Junca-Marti, S Juarez-Pomes, M Garrido-Ondono, S Blasco-Torres, L Molina-Corbacho, M Maldonado-Sotoca, Y Gasset-Teixidor, A Blasco-Moreu, J Turrado-Rodriguez, V Lacy, AM De Lacy, FB Morales, X Carreras-Castaner, A Torner, P Jornet-Gibert, M Balaguer-Castro, M Renau-Cerrillo, M Camacho-Carrasco, P Vives-Barquiel, M Campuzano-Bitterling, B Gracia, I Pujol-Muncunill, R Estaire Gomez, M Padilla-Valverde, D Sanchez-Garcia, S Sanchez-Pelaez, D Jimenez Higuera, E Picon Rodriguez, R Fernandez Camunas, A Martinez-Pinedo, C Garcia Santos, EP Munoz-Atienza, V Moreno Perez, A De la Manzanara Cano, LCA Crego-Vita, D Huecas-Martinez, M Domenech, J Rosello Anon, A Sanguesa, MJ Bernal-Sprekelsen, JC Catala Bauset, JC Renovell Ferrer, P Martinez Perez, C Gil-Albarova, O Gilabert Estelles, J Aghababyan, K Rivas, R Rivas, F Escartin, J Blas Laina, JL Nogues, A Cros, B Talal El-Abur, I Garcia Egea, J Yanez, C Kauppila, JH Sarjanoja, E Tzedakis, S Bouche, PA Gaujoux, S Gossot, D Seguin-Givelet, A Fuks, D Grigoroiu, M Salas, SR Cathelineau, X Macek, P Barbe, Y Rozet, F Barret, E Mombet, A Cathala, N Brian, E Zadegan, F Conso, C Baldwin, AJ West, R Gammeri, E Catton, A Kouris, MS Pereca, J Singh, J Patel, P Handa, S Kaushal, M Kler, A Reghuram, V Tezas, S Oktseloglou, V Mosley, F Monroy, DLCMF Bobak, P Omar, I Ahad, S Langlands, F Brown, V Hashem, M Williams, A Ridgway, A Pournaras, D Britton, E Lostis, E Ambler, GK Chu, H Hopkins, J Manara, J Chan, M Doe, M Moon, RDC Lawday, S Jichi, T Singleton, W Mannion, R Stewart, GD Ramzi, J Mohan, M Singh, AA Ashcroft, J Baker, OJ Coughlin, P Davies, RJ Durst, AZED Abood, A Habeeb, A Hudson, VE Kolias, A Lamb, B Luke, L Mitrasinovic, S Murphy, S Ngu, AWT O'Neill, JR Waseem, S Wong, K Georgiades, F Hutchinson, PJ Tan, XS Pushpa-rajah, J Colquhoun, A Masterson, L Abu-Nayla, I Walker, C Balakrishnan, A Rooney, S Irune, E Byrne, MH Durrani, A Richards, T Venkatesan, SA Combellack, T Williams, J Tahhan, G Mohammed, M Kornaszewska, M Valtzoglou, V Deglurkar, I Rahman, M Von Oppell, U Mehta, D Koutentakis, M Chek, SNSAH Hill, G Morris, C Shinkwin, M Torkington, J Cornish, J Houston, R Mannan, S Ayeni, F Tustin, H Bordenave, M Robson, A Vimalachandran, D Manu, N Eardley, N Krishnan, E Serevina, OL Martin, E Smith, C Jones, A Mahapatra, RS Clifford, R Matthews, W Mohankumar, K Khawaja, I Palepa, A Doulias, T Premakumar, Y Jauhari, Y Koshnow, Z Bowen, D Uberai, A Hirri, F Stubbs, BM McDonald, C Manickavasagam, J Ragupathy, K Davison, S Dalgleish, S McGrath, N Kanitkar, R Payne, CJ Ramsay, L Ng, CE Collier, T Khan, K Evans, R Brennan, C Henshall, DE Drake, T Harrison, EM Zamvar, V Tambyraja, A Skipworth, RJE Linder, G McGregor, R Brennan, P Mayes, J Ross, L Smith, S White, T Jamjoom, AAB Pasricha, R Holme, T Abbott, S Razik, A Thrumurthy, S Steinke, J Baker, M Howden, D Baxter, Z Osagie, L Bence, M Fowler, GE Massey, L Rajaretnam, N Evans, J John, J Goubran, A Campain, N McDermott, FD McGrath, JS Ng, M Pascoe, J Phillips, JRA Daniels, IR Raptis, DA Pollok, JM Machairas, N Davidson, B Fusai, G Soggiu, F Xyda, S Salinas, HC Tzerbinis, H Pissanou, T Gilliland, J Chowdhury, S Varcada, M Hart, C Mirnezami, R Knowles, J Angamuthu, N Vijay, V Shakir, T Hasan, R Tansey, R Ross, E Loubani, M Wilkins, A Cao, H Capitelli-McMahon, H Hitchman, L Ikram, H Andronic, A Ibrahim, AA Totty, J Tayeh, S Chase, T Humphreys, L Ayorinde, J Ghanbari, A Cuming, T Williams, K Chung, E Hagger, R Karim, A Hainsworth, A Flatman, M Trompeter, A Hing, C Brown, O Tsinaslanidis, P Benjamin, MW Leyte, A Tan, C Smelt, J Vaughan, P Santhirakumaran, G Hunt, I Raza, M Labib, A Luo, X Sudarsanam, A Rolls, A Lyons, O Onida, S Shalhoub, J Sugand, K Park, C Sarraf, KM Erridge, S Kinross, J Denning, M Yalamanchili, S Abuown, A Ibrahim, M Martin, G Davenport, D Wheatstone, S Andreani, SM Bath, MF Sahni, A Judkins, N Springford, RL Sohrabi, C Bacarese-Hamilton, J Taylor, FG Patki, P Tanabalan, C Reynolds, J Alexander, ME Smart, CJ Stylianides, N Abdalla, M Newton, K Bhatia, K Edmondson, R Abdeh, L Jones, D Zeiton, M Ismail, O Naseem, H Advani, R Fell, A Smith, A Halkias, C Evans, J Nikolaou, S English, C Kristinsson, S Oni, T Ilahi, N Ballantyne, K Woodward, Z Merh, R Robertson-Smith, B Mahmoud, A Ameerally, P Finch, JG Gnanachandran, C Pop, I Rogers, M Yousef, Y Mohamed, I Woods, R Zahid, H Mundy, G Aujayeb, A Townshend, D McLarty, N Shenfine, A Jackson, K Johnson, C Dass, D Ford, D Khan, J Thiruchandran, G Toh, SKC Ahmad, Y Allana, A Bellis, C Babawale, O Phan, YC Lokman, U Ismail, M Koc, T Witek, A Duggleby, L Shamoon, S Stefan, S Clancy, H Singh, S Mukherjee, S Ferguson, D Smith, C Mansuri, A Thakrar, A Wickramarachchi, L Cuthbert, R Sivayoganathan, S Chui, K Karam, E Dott, C Shankar, S Singh, R Lane, J Colvin, H Badran, A Cadersa, A Williams, S Cumpstey, A Hamady, Z Aftab, R Wensley, F Byrne, J Morrison-Jones, V Sekhon, GK Shields, H Shakoor, Z Yener, A Talbot, T Khan, A Alzetani, A Cresner, R Johnson, D Hughes, I Hall, J Rooney, J Chatterji, S Zhang, Y Owen, R Rudic, M Hunt, J Zakai, D Thomas, M Aladeojebi, A Ali, M Gaunt, A Barmayehvar, B Kitchen, M Gowda, M Mansour, F Jarvis, M Halliday, E Lefroy, R Nanjaiah, P Ali, S Kitchen, M Lin, DJ Rajgor, AD Scurrah, RJ Kang, C Watson, LJ Harris, G Royle, T Cunningham, Y James, G Steel, B Luk, ACO Stables, G Doorgakant, A Thiruvasagam, VG Carter, J Reid, S Mohammed, R Marlow, W Ferguson, H Wilkin, R Konstantinou, C Yershov, D Vatish, J Denning, A Das, R Powell, S Magee, C Agarwal, K Mangos, E Nambirajan, T Flindall, I Mahendran, V Hanson, A De Marchi, J Hill, A Farrell, T Davis, NF Kearney, D Nelson, T Picciariello, A Papagni, V Altomare, DF Granieri, S Cotsoglou, C Cabeleira, A Branco, C Serralheiro, P Alves, R Teles, T Lazaro, A Canhoto, C Simoes, J Costa, M Almeida, AC Nogueira, O Oliveira, A Athayde Nemesio, R Silva, M Lopes, C Amaral, MJ Valente da Costa, A Andrade, R Martins, R Guimaraes, A Guerreiro, P Ruivo, A Camacho, C Duque, M Santos, E Breda, D Oliveira, JM De Oliveira Lopez, AL Garrido, S Colino, M De Barros, J Correia, S Rodrigues, M Cardoso, P Martins, R Teixeira, J Soares, AP Morais, H Pereira, R Revez, T Manso, M Domingues, JC Henriques, P Ribeiro, R Ribeiro, V Cardoso, N Sousa, S Martins dos Santos, S Miranda, P Garrido, R Peralta Ferreira, M Ascensao, J Costeira, B Cunha, C Rio Rodrigues, L Sousa Fernandes, M Azevedo, P Ribeiro, J Lourenco, I Gomes, H Mendinhos, G Nobre Pinto, A Cardoso, P Martins, R Teixeira, J Soares, AP Morais, H Pereira, R Revez, T Manso, M Domingues, JC Henriques, P Ribeiro, R Ribeiro, V Cardoso, N Sousa, S Martins dos Santos, G Taflin, H Abdou, H Diaz, J Richmond, M Clark, J O'Meara, L Hanna, N Cooper, Z Salim, A Hirji, SA Brown, A Chung, C Hansen, L Okafor, BU Roxo, V Raut, CP Jolissaint, JS Mahvi, DA Reinke, C Ross, S Thompson, K Manning, D Perkins, R Volpe, A Merola, S Ssentongo, A Ssentongo, P Oh, JS Hazelton, J Maines, J Gusani, N Garner, M Horvath, S Martin, RCG Bhutiani, N Choron, R Peck, G Soliman, F Rehman, S Abbas, A Soliman, A Kim, B Jones, C Dauer, MDE Renza-Stingone, E Hernandez, E Gokcen, E Kropf, E Sufrin, H Hirsch, H Ross, H Engel, J Sewards, J Diaz, J Poggio, J Sanserino, K Rae, L Philp, M Metro, M McNelis, P Petrov, R Rehman, S Pazionis, T Quintana, M Jackson, H Lumenta, DB Nischwitz, SP Richtig, E Pau, M Srekl-Filzmaier, P Eibinger, N Michelitsch, B Fediuk, M Papinutti, A Seidel, G Kahn, J Cohnert, TU Kantor, E Kahiu, J Hossain, N Hosny, S Sultana, A Taggarsi, M Vitone, L Lambert, J Vaz, OP Sarantitis, I Shrestha, D Timbrell, S Shugaba, A Jones, GP Gardner, A Tripathi, SS Greenhalgh, MS Emerson, H Vejsbjerg, K Pearce, L McCormick, W Fisher, A Singisetti, K Aawsaj, Y Barry, C Blanco, J Vanker, R Ghobrial, M Jones, G Kanthasamy, S Fawi, H Awadallah, M Chen, F Cheung, J Tingle, S Abbadessa, F Sachdeva, A Rai, B Chan, CD McPherson, I Booth, K Ali, MF Pandanaboyana, S Grainger, T Nandhra, S Patience, A Rogers, A Roy, C Williams, T Dawe, N McCaffer, C Riches, J Bhattacharya, S Moir, J Kalson, NS Ahmed, EH Mellor, C Saleh, C Koshy, RM Hammond, J Sanderson, L Wahed, S Phillips, AW Ghosh, K Rogers, LJ Labib, PL Miller, D Minto, G Hope, N Marchbank, A Emslie, K Panahi, P Ho, B Perkins, C Clough, E Roy, H Enemosah, I Campbell, R Natale, J Gohil, K Rela, M Raza, N Menakaya, C Webb, J Antar, M Modi, N Sofat, R Noel, J Nunn, R Adegbola, S Eriberto, F Sharma, V Tanna, R Lodhia, S Carvalho, L Osorio, C Antunes, J Lourenco, S Balau, P Godinho, M Pereira, A Keller, DS Smart, NJ |
| Item Type: | Journal Article |
| Abstract: | Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis. Setting Prospective, international, multicentre, observational cohort study. Participants Patients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative). Primary outcome 30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality. Results This study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787). Conclusions Patients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups. Trial registration number NCT04323644 |
| Issue Date: | 1-Nov-2021 |
| Date of Acceptance: | 27-Aug-2021 |
| URI: | http://hdl.handle.net/10044/1/93660 |
| DOI: | 10.1136/bmjopen-2021-050830 |
| ISSN: | 2044-6055 |
| Publisher: | BMJ Journals |
| Start Page: | 1 |
| End Page: | 10 |
| Journal / Book Title: | BMJ Open |
| Volume: | 11 |
| Issue: | 11 |
| Copyright Statement: | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Science & Technology Life Sciences & Biomedicine Medicine, General & Internal General & Internal Medicine COVID-19 hip trauma management HIP-FRACTURES MORTALITY-RATES COMPLICATIONS MULTICENTER SURGERY COVID-19 hip trauma management Aged, 80 and over COVID-19 Cohort Studies Femoral Fractures Hip Fractures Humans Male Prospective Studies SARS-CoV-2 COVIDSurg Collaborative Science & Technology Life Sciences & Biomedicine Medicine, General & Internal General & Internal Medicine COVID-19 hip trauma management HIP-FRACTURES MORTALITY-RATES COMPLICATIONS MULTICENTER SURGERY 1103 Clinical Sciences 1117 Public Health and Health Services 1199 Other Medical and Health Sciences |
| Publication Status: | Published |
| Article Number: | ARTN e050830 |
| Online Publication Date: | 2021-11-30 |
| Appears in Collections: | Department of Surgery and Cancer Imperial College London COVID-19 |
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