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A compendium answering 150 questions on COVID-19 and SARS-CoV-2.
File | Description | Size | Format | |
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COVID-19 in 100 questions MANUSCRIPT v1.docx | Accepted version | 541.1 kB | Microsoft Word | View/Open |
Title: | A compendium answering 150 questions on COVID-19 and SARS-CoV-2. |
Authors: | Riggioni, C Comberiati, P Giovannini, M Agache, I Akdis, M Alves-Correia, M Antó, JM Arcolaci, A Kursat Azkur, A Azkur, D Beken, B Boccabella, C Bousquet, J Breiteneder, H Carvalho, D De Las Vecillas, L Diamant, Z Eguiluz-Gracia, I Eiwegger, T Eyerich, S Fokkens, W Gao, Y-D Hannachi, F Johnston, SL Jutel, M Karavelia, A Klimek, L Moya, B Nadeau, K O'Hehir, R O'Mahony, L Pfaar, O Sanak, M Schwarze, J Sokolowska, M Torres, MJ Van de Veen, W Van Zelm, MC Wang, DY Zhang, L Jiménez-Saiz, R Akdis, CA |
Item Type: | Journal Article |
Abstract: | In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socio-economic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thrombo-embolic complications and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. Over 140 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease. |
Issue Date: | Oct-2020 |
Date of Acceptance: | 7-Jun-2020 |
URI: | http://hdl.handle.net/10044/1/79932 |
DOI: | 10.1111/all.14449 |
ISSN: | 0105-4538 |
Publisher: | Wiley |
Start Page: | 2503 |
End Page: | 2541 |
Journal / Book Title: | Allergy |
Volume: | 75 |
Issue: | 10 |
Copyright Statement: | © 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is the accepted version of the following article: Riggioni, C, Comberiati, P, Giovannini, M, et al. A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2. Allergy. 2020; 75: 2503– 2541, which has been published in final form at https://doi.org/10.1111/all.14449 |
Keywords: | Science & Technology Life Sciences & Biomedicine Allergy Immunology allergy coronavirus disease 2019 COVID-19 SARS-CoV-2 severe acute respiratory syndrome-related coronavirus 2 ACUTE RESPIRATORY SYNDROME ANGIOTENSIN-CONVERTING ENZYME KAWASAKI-LIKE DISEASE SARS-CORONAVIRUS LONGITUDINAL PROFILE SPIKE GLYCOPROTEIN IMMUNE-RESPONSES EPIDEMIC ASTHMA TRANSMISSION COVID-19 SARS-CoV-2 allergy coronavirus disease 2019 severe acute respiratory syndrome-related coronavirus 2 Betacoronavirus Coronavirus Infections Humans Hypersensitivity Pandemics Pneumonia, Viral Humans Pneumonia, Viral Coronavirus Infections Hypersensitivity Pandemics Betacoronavirus COVID-19 SARS-CoV-2 allergen immunotherapy allergy asthma coronavirus disease 2019 cytokine storm syndrome epidemiology pandemic prevention severe acute respiratory syndrome-related coronavirus 2 Allergy 1107 Immunology |
Publication Status: | Published |
Conference Place: | Denmark |
Online Publication Date: | 2020-06-14 |
Appears in Collections: | National Heart and Lung Institute Faculty of Medicine Imperial College London COVID-19 |