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A compendium answering 150 questions on COVID-19 and SARS-CoV-2.

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Title: A compendium answering 150 questions on COVID-19 and SARS-CoV-2.
Authors: Riggioni, C
Comberiati, P
Giovannini, M
Agache, I
Akdis, M
Alves-Correia, M
Antó, JM
Arcolaci, A
Kursat Azkur, A
Azkur, D
Beken, B
Boccabella, C
Bousquet, J
Breiteneder, H
Carvalho, D
De Las Vecillas, L
Diamant, Z
Eguiluz-Gracia, I
Eiwegger, T
Eyerich, S
Fokkens, W
Gao, Y-D
Hannachi, F
Johnston, SL
Jutel, M
Karavelia, A
Klimek, L
Moya, B
Nadeau, K
O'Hehir, R
O'Mahony, L
Pfaar, O
Sanak, M
Schwarze, J
Sokolowska, M
Torres, MJ
Van de Veen, W
Van Zelm, MC
Wang, DY
Zhang, L
Jiménez-Saiz, R
Akdis, CA
Item Type: Journal Article
Abstract: In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socio-economic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thrombo-embolic complications and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. Over 140 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.
Issue Date: Oct-2020
Date of Acceptance: 7-Jun-2020
URI: http://hdl.handle.net/10044/1/79932
DOI: 10.1111/all.14449
ISSN: 0105-4538
Publisher: Wiley
Start Page: 2503
End Page: 2541
Journal / Book Title: Allergy
Volume: 75
Issue: 10
Copyright Statement: © 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is the accepted version of the following article: Riggioni, C, Comberiati, P, Giovannini, M, et al. A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2. Allergy. 2020; 75: 2503– 2541, which has been published in final form at https://doi.org/10.1111/all.14449
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
allergy
coronavirus disease 2019
COVID-19
SARS-CoV-2
severe acute respiratory syndrome-related coronavirus 2
ACUTE RESPIRATORY SYNDROME
ANGIOTENSIN-CONVERTING ENZYME
KAWASAKI-LIKE DISEASE
SARS-CORONAVIRUS
LONGITUDINAL PROFILE
SPIKE GLYCOPROTEIN
IMMUNE-RESPONSES
EPIDEMIC
ASTHMA
TRANSMISSION
COVID-19
SARS-CoV-2
allergy
coronavirus disease 2019
severe acute respiratory syndrome-related coronavirus 2
Betacoronavirus
Coronavirus Infections
Humans
Hypersensitivity
Pandemics
Pneumonia, Viral
Humans
Pneumonia, Viral
Coronavirus Infections
Hypersensitivity
Pandemics
Betacoronavirus
COVID-19
SARS-CoV-2
allergen immunotherapy
allergy
asthma
coronavirus disease 2019
cytokine storm syndrome
epidemiology
pandemic
prevention
severe acute respiratory syndrome-related coronavirus 2
Allergy
1107 Immunology
Publication Status: Published
Conference Place: Denmark
Online Publication Date: 2020-06-14
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine
Imperial College London COVID-19