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Emerging technologies for low-cost, rapid vaccine manufacture
File | Description | Size | Format | |
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BTJ-review-VaccineManufacturing_Accepted_for Symplectic.docx | Accepted version | 4.62 MB | Microsoft Word | View/Open |
Title: | Emerging technologies for low-cost, rapid vaccine manufacture |
Authors: | Kis, Z Shattock, R Shah, N Kontoravdi, K |
Item Type: | Journal Article |
Abstract: | To stop the spread of future epidemics and meet infant vaccination demands in low‐ and middle‐income countries, flexible, rapid and low‐cost vaccine development and manufacturing technologies are required. Vaccine development platform technologies that can produce a wide range of vaccines are emerging, including: a) humanized, high‐yield yeast recombinant protein vaccines; b) insect cell‐baculovirus ADDomer vaccines; c) Generalized Modules for Membrane Antigens (GMMA) vaccines; d) RNA vaccines. Herein, existing and future platforms are assessed in terms of addressing challenges of scale, cost, and responsiveness. To assess the risk and feasibility of the four emerging platforms, the following six metrics are applied: 1) technology readiness; 2) technological complexity; 3) ease of scale‐up; 4) flexibility for the manufacturing of a wide range of vaccines; 5) thermostability of the vaccine product at tropical ambient temperatures; and 6) speed of response from threat identification to vaccine deployment. The assessment indicated that technologies in the order of increasing feasibility and decreasing risk are the yeast platform, ADDomer platform, followed by RNA and GMMA platforms. The comparative strengths and weaknesses of each technology are discussed in detail, illustrating the associated development and manufacturing needs and priorities. |
Issue Date: | 10-Jan-2019 |
Date of Acceptance: | 30-Oct-2018 |
URI: | http://hdl.handle.net/10044/1/65963 |
DOI: | https://dx.doi.org/10.1002/biot.201800376 |
ISSN: | 1860-6768 |
Publisher: | Wiley |
Journal / Book Title: | Biotechnology Journal |
Volume: | 14 |
Copyright Statement: | © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Kis, Z. , Shattock, R. , Shah, N. and Kontoravdi, C. (2019), Emerging Technologies for Low‐Cost, Rapid Vaccine Manufacture. Biotechnol. J., 14: 1800376., which has been published in final form at https://dx.doi.org/10.1002/biot.201800376 |
Sponsor/Funder: | Engineering & Physical Science Research Council (EPSRC) |
Funder's Grant Number: | EP/R013764/1 |
Keywords: | RNA vaccines bacterial outer-membrane vesicle vaccines insect cell-baculovirus vaccine manufacturing vaccine manufacturing technology assessment yeast-based vaccine manufacturing platform 1002 Environmental Biotechnology 1003 Industrial Biotechnology 1004 Medical Biotechnology Biotechnology |
Publication Status: | Published |
Article Number: | 1800376 |
Online Publication Date: | 2018-12-10 |
Appears in Collections: | Centre for Environmental Policy Chemical Engineering Department of Medicine (up to 2019) Faculty of Natural Sciences Faculty of Engineering |