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Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy

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Title: Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy
Authors: Carter, P
Alifrangis, C
Cereser, B
Chandrasinghe, P
Del Bel Belluz, L
Fotopoulou, C
Frilling, A
Herzog, T
Moderau, N
Tabassum, N
Krell, J
Stebbing, J
Item Type: Journal Article
Abstract: Tumor molecular profiling has enabled selection of targeted therapies in a host of solid tumors. Here we used a retrospective clinical cohort, to evaluate the benefit of tailoring treatments for female genital tract malignancy, using tumor molecular profiles. Clinical outcome data for 112 patients was retrospectively separated into two groups. These either followed a matched treatment plan that incorporated at least one drug recommended according to their tumor profile and none that were expected to have no benefit (64 patients), or was unmatched with suggested treatments and received at least one drug that was anticipated to lack benefit for that tumor (48 patients). In the group of patients whose drugs matched those recommended by molecular profiling of their tumor, their overall survival was 593 days on average, compared to 449 days for patients that did not; removing drugs predicted to have no benefit from treatment regimens received after profiling increased survival by 144 days on average (P = 0.0265). In the matched treatment group, 30% of patients had died by the last time of monitoring, whereas this was 40% in the unmatched group (P = 0.2778). The IHC biomarker for the progesterone receptor was demonstrated to be prognostic for survival.
Issue Date: 27-Dec-2017
Date of Acceptance: 14-Nov-2017
URI: http://hdl.handle.net/10044/1/56270
DOI: https://dx.doi.org/10.18632/oncotarget.23675
ISSN: 1949-2553
Publisher: Impact Journals
Start Page: 6007
End Page: 6014
Journal / Book Title: Oncotarget
Volume: 9
Issue: 5
Copyright Statement: Licensed under a Creative Commons Attribution 3.0 License
Keywords: tumor profiling
female genital tract malignancy
cancer treatment
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer