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Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens

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Title: Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens
Authors: Dart, DA
Brooke, GN
Sita-Lumsden, A
Waxman, J
Bevan, CL
Item Type: Journal Article
Issue Date: 1-Oct-2012
URI: http://hdl.handle.net/10044/1/52680
DOI: https://dx.doi.org/10.1038/onc.2011.591
ISSN: 0950-9232
Publisher: NATURE PUBLISHING GROUP
Start Page: 4588
End Page: 4598
Journal / Book Title: ONCOGENE
Volume: 31
Issue: 43
Copyright Statement: Copyright © 2011, Rights Managed by Nature Publishing Group
Sponsor/Funder: Medical Research Council (MRC)
Cancer Research UK
Prostate Cancer UK
Funder's Grant Number: G0700915
12196
PG10-25
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Oncology
Cell Biology
Genetics & Heredity
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
GENETICS & HEREDITY
ONCOLOGY
prohibitin
androgen receptor
prostate
androgens
castrate-resistant prostate cancer
corepressor
TRANSCRIPTIONAL REPRESSION
CANCER CELLS
NUCLEUS
PROTEIN
RAT
SUPERFAMILY
RECRUITMENT
SUPPRESSION
PROGRESSION
SENESCENCE
Acetylation
Adrenal Glands
Androgens
Female
Gene Knockdown Techniques
Histones
Humans
Male
Promoter Regions, Genetic
Prostatic Neoplasms
Protein Binding
Receptors, Androgen
Repressor Proteins
1112 Oncology And Carcinogenesis
1103 Clinical Sciences
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer