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Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)
| File | Description | Size | Format | |
|---|---|---|---|---|
 Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).pdf | Published version | 3.3 MB | Adobe PDF | View/Open |
| Title: | Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP) |
| Authors: | Rackham, MD Brannigan, JA Rangachari, K Meister, S Wilkinson, AJ Holder, AA Leatherbarrow, RJ Tate, EW |
| Item Type: | Journal Article |
| Issue Date: | 5-Mar-2014 |
| URI: | http://hdl.handle.net/10044/1/26923 |
| DOI: | https://dx.doi.org/10.1021/jm500066b |
| ISSN: | 0022-2623 |
| Publisher: | American Chemical Society |
| Start Page: | 2773 |
| End Page: | 2788 |
| Journal / Book Title: | Journal of Medicinal Chemistry |
| Volume: | 57 |
| Issue: | 6 |
| Copyright Statement: | © 2014 American Chemical Society. This article is under a CC BY licence |
| Keywords: | Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy ANTIMALARIAL-DRUG DISCOVERY MEDICINAL CHEMISTRY MALARIA SYSTEM RESISTANCE STABILITY ACYLATION VACUOLE |
| Publication Status: | Published |
| Appears in Collections: | Chemistry Biological and Biophysical Chemistry Faculty of Natural Sciences |