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A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition

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Monfort Sanchez (2023) - SPIE BiOS - 12369-27 (submitted version).pdfAccepted version671.58 kBAdobe PDFView/Open
Title: A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition
Authors: Monfort Sánchez, E
Avery, J
Gan, J
Qian, J
Mwiinga, M
Banda, R
Hoare, J
Ashranfian, H
Darzi, A
Kelly, P
Thompson, AJ
Item Type: Conference Paper
Abstract: Undernutrition is associated with approximately 45% of deaths among children under the age of 5. Furthermore, in 2020, around 149 million children suffered impaired physical/cognitive development due to lack of adequate nutrition. Environmental enteropathy (EE) is associated with undernutrition and is characterized by a multifaceted breakdown in gut function, including an increase in intestinal permeability that can lead to inflammatory responses. However, the role and mechanisms associated with EE (particularly gut permeability) are not well understood. This is partly because current techniques to assess changes in gut permeability, such as endoscopic biopsies, histopathology and chemical tests such as Lactulose:Mannitol assays, are either highly invasive, unreliable or difficult to perform on specific groups of patients (such as infants and patients with urine retention problems). Therefore, low-cost, non-invasive and reliable diagnostic tools are urgently needed for better evaluation of intestinal permeability. Here, we present a compact transcutaneous fluorescence spectroscopy sensor for non-invasive evaluation of gut permeability and report the first in vivo data collected from volunteers in an undernutrition trial. Using this technique and device, fluorescence signals are detected transcutaneously after oral ingestion of a fluorescent solution. Preliminary results demonstrate the potential use of the presented sensor for clinical assessment of gut permeability in low-income settings.
Editors: Levitz, D
Ozcan, A
Issue Date: 6-Mar-2023
Date of Acceptance: 1-Mar-2023
URI: http://hdl.handle.net/10044/1/104613
DOI: 10.1117/12.2649030
ISBN: 9781510658431
ISSN: 1605-7422
Publisher: SPIE
Start Page: 1
End Page: 7
Journal / Book Title: Optics and Biophotonics in Low-Resource Settings IX
Copyright Statement: Copyright © 2023 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/V012452/1
Conference Name: Optics and Biophotonics in Low-Resource Settings IX
Publication Status: Published
Start Date: 2023-01-28
Finish Date: 2023-02-03
Online Publication Date: 2023-03-06
Appears in Collections:Department of Surgery and Cancer
Institute of Global Health Innovation



This item is licensed under a Creative Commons License Creative Commons