43
IRUS TotalDownloads
Altmetric
Aromatic oligoesters as novel helix mimetic scaffolds
| File | Description | Size | Format | |
|---|---|---|---|---|
 1-s2.0-S0968089623001591-main.pdf | Published version | 2.02 MB | Adobe PDF | View/Open |
| Title: | Aromatic oligoesters as novel helix mimetic scaffolds |
| Authors: | Haque, M Flack, T Singh, R Wall, A Vieira de Castro, G Jiang, L White, A Barnard, A |
| Item Type: | Journal Article |
| Abstract: | The design, synthesis, and conformational analysis of a novel aromatic oligoester helix mimetic scaffold is reported. A range of amino acid-type side-chain functionality can be readily incorporated into monomer building blocks over three facile synthetic steps. Analysis of representative dimers revealed a stable conformer capable of effective mimicry of a canonical α-helix and the scaffold was found to be surprisingly stable to degradation in aqueous solutions at acidic and neutral pH. |
| Issue Date: | 3-May-2023 |
| Date of Acceptance: | 28-Apr-2023 |
| URI: | http://hdl.handle.net/10044/1/104264 |
| DOI: | 10.1016/j.bmc.2023.117311 |
| ISSN: | 0968-0896 |
| Publisher: | Elsevier |
| Journal / Book Title: | Bioorganic and Medicinal Chemistry |
| Volume: | 87 |
| Copyright Statement: | © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Publication Status: | Published |
| Article Number: | ARTN 117311 |
| Online Publication Date: | 2023-05-07 |
| Appears in Collections: | Chemistry Biological and Biophysical Chemistry |
This item is licensed under a Creative Commons License
