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Long-term (180-Day) outcomes in critically Ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
REMAP CAP LTO manuscript_R1[52].docx
LTO_Figure2_R1.pdf| Title: | Long-term (180-Day) outcomes in critically Ill patients with COVID-19 in the REMAP-CAP randomized clinical trial |
| Authors: | Florescu, S Stanciu, D Zaharia, M Kosa, A Codreanu, D Kidwai, A Masood, S Kaye, C Coutts, A MacKay, L Summers, C Polgarova, P Farahi, N Fox, E McWilliam, S Hawcutt, D Rad, L O’Malley, L Whitbread, J Jones, D Dore, R Saunderson, P Kelsall, O Cowley, N Wild, L Thrush, J Wood, H Austin, K Bélteczki, J Magyar, I Fazekas, Á Kovács, S Szőke, V Donnelly, A Kelly, M Smyth, N O’Kane, S McClintock, D Warnock, M Campbell, R McCallion, E Azaiz, A Charron, C Godement, M Geri, G Vieillard-Baron, A Johnson, P McKenna, S Hanley, J Currie, A Allen, B McGoldrick, C McMaster, M Mani, A Mathew, M Kandeepan, R Vignesh, C TV, B Ramakrishnan, N James, A Elvira, E Jayakumar, D Pratheema, R Babu, S Ebenezer, R Krishnaoorthy, S Ranganathan, L Ganesan, M Shree, M Guilder, E Butler, M Cowdrey, K-A Robertson, M Ali, F McMahon, E Duffy, E Chen, Y Simmonds, C McConnochie, R O’Connor, C El-Khawas, K Richardson, A Hill, D Commons, R Abdelkharim, H Saxena, M Muteithia, M Dobell-Brown, K Jha, R Kalogirou, M Ellis, C Krishnamurthy, V O’Connor, A Thurairatnam, S Mukherjee, D Kaliappan, A Vertue, M Nicholson, A Riches, J Maloney, G Kittridge, L Solesbury, A Ramos, A Collins, D Brickell, K Reid, L Smyth, M Breen, P Spain, S Curley, G McEvoy, N Geoghegan, P Clarke, J Silversides, J McGuigan, P Ward, K O’Neill, A Finn, S Wright, C Green, J Collins, É Knott, C Smith, J Boschert, C Slieker, K Ewalds, E Sanders, A Wittenberg, W Geurts, H Poojara, L Sara, T Nand, K Reeve, B Dechert, W Phillips, B Oritz-Ruiz de Gordoa, L Affleck, J Shaikh, A Murray, A Ramanan, M Frakking, T Pinnell, J Robinson, M Gledhill, L Wood, T Sanghavi, R Bhonagiri, D Ford, M Parikh, HG Avard, B Nourse, M McDonald, B Edmunds, N Hoiting, O Peters, M Rengers, E Evers, M Prinssen, A Morgan, M Cole, J Hill, H Davies, M Williams, A Thomas, E Davies, R Wise, M Grimm, P Soukup, J Wetzold, R Löbel, M Starke, L Lellouche, F Lizotte, P Declerq, P Antoine, M Stephanie, G Jean-Pierre, E François, B Marion, B Philippe, R Pourcine, F Monchi, M Luis, D Mercier, R Sagnier, A Verrier, N Caplin, C Richecoeu, J Combaux, D Siami, S Aparicio, C Vautier, S Jeblaoui, A Lemaire-Brunel, D D'Aragon, F Carbonneau, E Leblond, J Plantefeve, G Leparco, C Contou, D Fartoukh, M Courtin, L Labbe, V Voiriot, G Salhi, S Chassé, M Carrier, F Boumahni, D Benettaib, F Ghamraoui, A Sement, A Gachet, A Hanisch, A Haffiane, A Boivin, A-H Barreau, A Guerineau, E Poupblanc, S Egreteau, P Lefevre, M Bocher, S Le Loup, G Le Guen, L Carn, V Bertel, M Antcliffe, D Templeton, M Rojo, R Coghlan, P Smee, J Barker, G Finn, A Kreb, G Hoff, U Hinrichs, C Nee, J Mackay, E Cort, J Whileman, A Spencer, T Spittle, N Beavis, S Padmakumar, A Dale, K Hawes, J Moakes, E Gascoyne, R Pritchard, K Stevenson, L Cooke, J Nemeth-Roszpopa, K Gauli, B Bastola, S Muller, G Nay, M-A Kamel, T Benzekri, D Jacquier, S Runge, I Mathonnet, A Barbier, F Bretagnol, A Carter, J Van Der Heyden, K Mehrtens, J Morris, A Morgan, S Burke, T Mercier, E Chartier, D Salmon, C Dequin, P-F Garot, D Bellemare, D Cloutier, È Daher, R Costerousse, O Boulanger, M-C Couillard-Chénard, É Lauzier, F Francoeur, C Francois, B Gay, A Anne-Laure, F Ramali, M HC, O Ghosh, A Osagie, R Arachchige, M Hartley, M Cheung, W Wong, H Seigne, P Eustace, J O'Callaghan, A-M O'Brien, F Bamford, P Reid, A Cawley, K Faulkner, M Pickering, C Raj, A Tsinaslanidis, G Khade, R Agha, G Sekiwala, R Smith, T Brewer, C Gregory, J Limb, J Cowton, A O’Brien, J Postlethwaite, K Malakouti, S Music, E Ricketts, D King, A Clermont, G Bart, R Mayr, F Schoenling, A Andreae, M Shetty, V Brant, E Malley, B Donadee, C Sackrowitz, R Weissman, A Yealy, D Barton, D Talia, N Nikitas, N Wells, C Lankester, L McMillan, H Van den Oever, H Kruisdijk-Gerritsen, A Haidar, G Bain, W Barbash, I Fitzpatrick, M Franz, C Kitsios, G Moghbeli, K Rosborough, B Shah, F Suber, T Pulletz, M Williams, P Birch, J Wiseman, S Horton, S Alegria, A Turki, S Elsefi, T Crisp, N Allen, L Truman, N Smith, M Chukkambotla, S Goddard, W Duberley, S Khan, M Kazi, A Simpson, J Duke, G Chan, P Carter, B Hunter, S Voigt, I Schueler, R Blank, E Hüning, V Steffen, M Goralski, P Litton, E Regli, A Pellicano, S Palermo, A Eroglu, E Bihari, S Laver, RD Jin, X Brown, J McIntyre, J French, C Bates, S Towns, M Yang, Y McGain, F McCullagh, I Cairns, T Hanson, H Patel, B Clement, I Evetts, G Touma, O Holland, S Hodge, C Taylor, H Alderman, M Barnes, N Da Rocha, J Smith, C Brooks, N Weerasinghe, T Sinclair, J-A Abusamra, Y Doherty, R Cudlipp, J Singh, R Yu, H Daebis, A Ng, C Kendrick, S Saran, A Makky, A Greener, D Rowe-Leete, L Edwards, A Bland, Y Dolman, R Foster, T Laffey, J McNicholas, B Scully, M Casey, S Kernan, M Brennan, A Rangan, R Tully, R Corbett, S McCarthy, A Duffy, O Burke, D Linnett, V Sanderson, A Ritzema, J Wild, H Lucas, R Marriott, Y Andric, Z Cviljevic, S Br, R Zapalac, M Mirković, G Khare, D Pinder, M Gopinath, A Kannan, T Dean, S Vanmali, P Depuydt, P De Waele, J De Bus, L Fierens, J Bracke, S Vermassen, J Vermeiren, D Pugh, R Lean, R Qiu, X Scanlan, J Evans, A Davies, G Lewis, J Plesnikova, Y Khoud, A Coetzee, S Puxty, K Cathcart, S Rimmer, D Bagot, C Scott, K Martin, L Yusuff, H Isgro, G Brightling, C Bourne, M Craner, M Boyles, R Alexander, B Roberts, T Nelli, A Rosenstein-Sisson, R Speyer, R Pech, Y McCullough, J Tallott, M Vazquez-Grande, G Marten, N Liu, T Siddiqui, A Khanal, S Amatya, S Szakmany, T Cherian, S Williams, G James, C Waters, A Prout, R Stedman, R Davies, L Pegler, S Kyeremeh, L Moorhouse, L Arbane, G Marotti, M Bociek, A Campos, S Van Nieuwkoop, K Ottens, T Visser, Y Van den Berg, L Van der Kraan-Donker, A Brett, S Arias, S Hall, R Paneru, H Koirala, S Paudel, P Wilson, M Vaara, S Pettilä, L Heinonen, J Pettilä, V Jain, S Gupta, A Holbrook, C Antoine, P Meziani, F Allam, H Cattelan, J Clere-Jehl, R Helms, J Kummerlen, C Merdji, H Monnier, A Rahmani, H Studer, A Schneider, F Castelain, V Morel, G L’Hotellier, S Ochin, E Vanjak, C Rouge, P Bendjemar, L Albert, M Serri, K Cavayas, A Duplaix, M Williams, V Catorze, NJTADS Pereira, TNAL Ferreira, RMC Bastos, JMPS Batista, TMO Badie, J Berdaguer, F Malfroy, S Mezher, C Bourgoin, C Moneger, G Bouvier, E Muñoz-Bermúdez, R Marin-Corral, J Degracia, A Gómez, F López, M Aceto, R Aghemo, A Badalamenti, S Brunetta, E Cecconi, M Ciccarelli, M Constantini, E Greco, M Folci, M Selmi, C Voza, A Henning, J Bonner, S Hugill, K Cirstea, E Wilkinson, D Jones, J Altomy, M Karlikowski, M Sutherland, H Wilhelmsen, E Woods, J North, J Pletz, M Hagel, S Ankert, J Kolanos, S Bloos, F Simons, K Van Zuylen, T Bouman, A Kumar, N Panwar, R Poulter, A-L Sunkara, K Szigligeti, G Leszkoven, J Rochwerg, B Karachi, T Oczkowski, S Centofanti, J Millen, T Sundaran, D Hollos, L Williams, A Turns, M Walsh, J Al Qasim, E Alswaidan, L Hegazy, M Arishi, H Al Amri, A AlQahtani, S Naidu, B Tlayjeh, H Hussain, S Al Enezi, F Abdukahil, SA Hopkins, P Smith, J Noble, H O’Reilly, K Mehta, R Wong, O Makanju, E Rao, D Sikondari, N Saha, S Corcoran, E Pappa, E Cockrell, M Donegan, C Balaie, M Nickoleit-Bitzenberger, D Schaaf, B Meermeier, W Prebeg, K Azzaui, H Hower, M Brieger, K-G Elender, C Sabelhaus, T Riepe, A Akamp, C Kremling, J Klein, D Landsiedel-Mechenbier, E Laha, S Verlander, M Williams, A Jha, A Megarbane, B Voicu, S Deye, N Malissin, I Sutterlin, L Mrad, A Lehalleur, A Naim, G Nguyen, P Ekhérian, J-M Boué, Y Sidéris, G Vodovar, D Guérin, E Grant, C Brain, M Mineall, S Paramasivam, E Wilby, E Ogg, B Howcroft, C Aspinwall, A Charlton, S Gould, R Mistry, D Awan, S Bedford, C Carr-Wilkinson, J Hall, A Cooke, J Gardiner-Hill, C Maloney, C Brunskill, N Watchorn, O Hardy, C Qureshi, H Flint, N Nicholson, S Southin, S Nicholson, A Ghattaoraya, A Harding, D O’Halloran, S Collins, A Smith, E Trues, E Borgatta, B Turner-Bone, I Reddy, A Wilding, L Wilson, C Surti, Z Aneman, A Miller, J White, H Estensen, K Morrison, L Sutton, J Cooper, M Warnapura, L Agno, R Sathianathan, P Shaw, D Ijaz, N Spong, A Sabaretnam, S Burns, D Lang, E Tate, M Fischer, R Biradar, V Soar, N Golden, D Davey, M Seaman, R Osborne, A Bannard-Smith, J Clark, R Birchall, K Henry, J Pomeroy, F Quayle, R Wylie, K Sukuraman, A John, M Sibin, S Leditschke, A Finnis, M Jongebloed, K Khwaja, K Campisi, J Van Vonderen, M Pietersma, M Vrolijk, L Kampschreur, L Van Gulik, L Makowski, A Misztal, B Haider, S Liao, A Squires, R Oborska, A Kayani, A Kalchko-Veyssal, S Prabakaran, R Hadebe, B KalchkoVeyssal, S Williams, T Song, R Morpeth, S Lai, V Habraken, H Stewart, R Mwaura, E Mew, L Wren, L Willams, F Sutherland, S-B Rebello, R Shehabi, Y Al-Bassam, W Hulley, A Kadam, U Sathianathan, K Innes, R Doble, P Graham, L Shovelton, C Dean, T Salahuddin, N Aryal, D Koirala, K Rai, N Luitel, S Seppelt, I Whitehead, C Lowrey, J Gresham, R Masters, K Hamlyn, V Hawkins, N Roynon-Reed, A Cutler, S Lewis, S Lazaro, J Newman, T Aravindan, L Asghar, A Bartholomew, J Bayne, M Beddows, S Birch, C Brend, M Byrne, R Campbell, D Campbell, H Chambers, E Clinton, A Collins, J Crawshaw, S Dawson, LA Donaldson, K Drake, C Dyas, S Ellis, Y Gilmour, K Goodwin, J Halden, S Hall, AS Hanson, J Harper, H Harrison, S Hayes, A Hodgson, H Hurford, S-A Jackson, S Levett, C Lock, S Lockett, T Logan, M Lomme, K Luo, J Marsh, E McKenna, S Mguni, N Monaghan, H Murphy, S Muzengi, N Naz, M O'Kell, E Oliver, A O'Reilly, J Pearson, K Porter, D Potter, A Rook, C Rounds, C Sheffield, J Shirley, K Siewersk, C Skinner, T Speight, H Sutu, M Unsworth, A Van’t Hoff, W Walker, S Williams, H Williams, P Williamson, D Williamson, JD Duan, E Tsang, J Patterson, L Austin, P Chapman, S Cabrelli, L Fletcher, S Nortje, J Fottrell-Gould, D Randell, G Stammers, K Healey, G Pinto, M Borrill, Z Duncan, T Ustianowski, A Uriel, A Eltayeb, A Alfonso, J Hey, S Shaw, J Fox, C Lindergard, G Charles, B Blackledge, B Connolly, K Harris, J Cuesta, J Xavier, K Purohit, D Elhassan, M Haldeos, A Vincent, R Abdelrazik, M Jenkins, S Ganesan, A Kumar, R Carter, D Bakthavatsalam, D Frater, A Saleem, M Everitt, R Hacking, D Zaman, M Elmahi, E Jones, A Hall, K Phillips, M Terrill, L Mills, G Raithatha, A Bauchmuller, K Ryalls, K Harrington, K Bowler, H Sall, J Bourne, R Gross, J Massey, N Adebambo, O Long, M Tony, K Juffermans, N Koopmans, M Dujardin, R Alderink, B Rowland, M Hutton, P Bashyal, A Davidson, N Hird, C Chhablani, M Phalod, G Kirkby, A Archer, S Netherton, K Reschreiter, H Camsooksai, J Patch, S Jenkins, S Humphrey, C Flynn, G Harrington, C Kruger, P Walsham, J Meyer, J Harward, M Jones, C Sathe, S Roche, L Davies, E Skinner, D Gaylard, J Newman, J Pogson, D Rose, S Daly, Z Brimfield, L Nown, A Parekh, D Bergin, C Bates, M McGhee, C Lynch, D Bhandal, K Tsakiridou, K Bamford, A Cooper, L Whitehouse, T Veenith, T Forster, E O'Connell, M Sim, M Hay, S Henderson, S Nygren, M Valentine, E Katary, A Bell, G Wilcox, L Mataliotakis, M Smith, P Ali, M Isguzar, A Phull, M-K Zaidi, A Pogreban, T Rosaroso, L Harvey, D Lowe, B Meredith, M Ryan, L Schouten, J Pickkers, P Roovers, N Klop-Riehl, M Van der Eng, H Sloots-Cuppen, S Preijers, L Van Oosten, N Moine, P Heming, N Maxime, V Bossard, I Nicholier, T Clair, B Orlikowski, D Bounab, R Abdeladim, L Baker, S Duroux, M Ratcliffe, M Sy, E Mailman, J Lee, S Gupta, C Kassir, S López, R Rodríguez-Gómez, J Cárcel, S Carmona, R De la Fuente, C Rodriguez, M Jan Hassing, R Greven, F Huijbens, D Roebers, L Verheij, H Miles, H Attokaran, A Buehner, U Williams, E Chapman, M O’Connor, S Glasby, K Rivett, J Brown, N Kutsogiannis, D Thompson, P Rooney, K Rodden, N Thomson, N McGlynn, D Abel, L Gemmell, L Sundaram, R Hornsby, J Walden, A Keating, L Frise, M Rai, S Bartley, S Schuster-Bruce, M Pitts, S Miln, R Purandare, L Vamplew, L Patel, B Dempster, D Gummadi, M Dormand, N Wang, S Spivey, M Bean, S Burt, K Moore, L Hammonds, F Richards, C Campbell, L Smyth, K Day, C Zitter, L Benyon, S Singh, J Lynch, C Mikusek, J Deacon, B Turner, K Baker, E Hickey, J Champanerkar, S Aitken, L LewisProsser, L Ahmad, N Wiles, M Willson, J 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Summerfield, A Dark, P Harvey, A Doonan, R McMorrow, L Knowles, K Pendlebury, J Lee, S Perez, J Marsden, T Taylor, M Michael, A Collis, M Claxton, A Habeichi, W Horner, D Slaughter, M Thomas, V Proudfoot, N Keatley, C Donnison, P Casey, R Irving, B Matimba-Mupaya, W Reed, C Anthony, A Trim, F Cambalova, L Robertson, D Wilson, A Hulme, J Kannan, S Kinney, F Senya, H Hayes, A Ratnam, V Gill, M Kirk, J Shelton, S Schweikert, S Wibrow, B Anstey, M Rauniyar, R Khoso, N Asif, N Taqdees, H Frey, C Scano, R McKee, M Murphy, P Thomas, M Worner, R Faulkner, B Gendall, E Hayes, K Blakemore, H Borislavova, B Deshpande, K Van Haren, F Konecny, P Inskip, D Tung, R Hayes, L Murphy, L Neill, A Reidy, B O’Dwyer, M Ryan, D Ainscough, K Hamilton-Davies, C Chan, C Mfuko, C Abbass, H Mandadapu, V Leaver, S Patel, K Farnell-Ward, S Saluzzio, R Rawlins, S Sicat, C De Keulenaer, B Ferrier, J Fysh, E Davda, A Mevavala, B Cook, D Clarke, F Banach, D Fernández de Pinedo Artaraz, Z Cabreros, L Latham, V Kruisselbrink, R Brochard, L Burns, K Sandhu, G Khalid, I White, I Croft, M Holland, N Pereira, R Nair, P Buscher, H Reynolds, C Newman, S Santamaria, J Barbazza, L Homes, J Smith, R Zaki, A Johnson, D Garrard, H Juhaz, V Brown, L Pemberton, A Roy, A Rostron, A Woods, L Cornell, S Fowler, R Adhikari, N Kamra, M Marinoff, N Garrett, P Murray, L Brailsford, J Fennessy, G Mulder, J Morgan, R Pillai, S Harford, R Ivatt, H Evans, D Richards, S Roberts, E Bowen, J Ainsworth, J Kuitunen, A Karlsson, S Vahtera, A Kiiski, H Ristimäki, S Albrett, J Jackson, C Kirkham, S Tamme, K Reinhard, V Ellervee, A Põldots, L Rennit, P Svitškar, N Browne, T Grimwade, K Goodson, J Keet, O Callender, O Udy, A McCracken, P Young, M Board, J Martin, E Kasipandian, V Patel, A Allibone, S Mary-Genetu, R English, S Watpool, I Porteous, R Miezitis, S McIntyre, L Brady, K Vale, C Shekar, K Lavana, J Parmar, D Peake, S Kurenda, C Hormis, A Walker, R Collier, D Kimpton, S Oakley, S Bhagani, S De Neef, M Garcia, S Maharajh, A Nandani, A Dobson, J Fernando, G Eastgate, C Gomez, K Abdi, Z Tatham, K Jhanji, S Black, E Dela Rosa, A Howle, R Baikady, R Tully, R Drummond, A Dearden, J Philbin, J Munt, S Gopal, S Pooni, J-S Ganguly, S Smallwood, A Metherell, S Naeem, A Fagan, L Ryan, E Mariappa, V Smith, J Foulds, A Revill, A Bhattarai, B De Jonge, E Wigbers, J Del Prado, M Cremer, O Mulier, J Peters, A Romberg, B Schutgens, R Troeman, D Van Opdorp, M Besten, H Brakké, K Barber, R Hilldrith, A Kluge, S Nierhaus, A Jarczak, D Roedl, K Kochanek, M Rueß-Paterno, G Mc-Kenzie, J Eichenauer, D Shimabukuro-Vornhagen, A Wilcox, E Del Sorbo, L Abdelhady, H Romagnuolo, T Simpson, S Maiden, M Horton, M Trickey, J Krajinovic, V Kutleša, M Kotarski, V Brohi, F Jagannathan, V Clark, M Purvis, S Wetherill, B Brajković, A Babel, J Sever, H Dragija, L Kušan, I Dushianthan, A Cusack, R De Courcy-Golder, K Salmon, K Burnish, R Smith, S Jackson, S Ruiz, W Duke, Z Johns, M Male, M Gladas, K Virdee, S Swabe, J Tomlinson, H Rohde, G Grünewaldt, A Bojunga, J Petros, S Kunz, K Schütze, B Weismann, D Frey, A Drayss, M Goebeler, ME Flor, T Fragner, G Wahl, N Totzke, J Sayehli, C Hakak, S Altaf, W O'Sullivan, M Murphy, A Walsh, L Rega La Valle, A Bewley, J Sweet, K Grimmer, L Johnson, R Wyatt, R Morgan, K Varghese, S Willis, J Stratton, E Kyle, L Putensen, D Drury, K Skorko, A Bremmer, P Ward, G Bassford, C Sligl, W Baig, N Rewa, O Bagshaw, S Basile, K Stavor, D Burbee, D McNamara, A Wunderley, R Bensen, N Richardson, A Adams, P Vita, T Buhay, M Scholl, D Gilliam, M Winters, J Doherty, K Berryman, E Ghaffari, M Marroquin, O Quinn, K Garrard, W Kalchthaler, K Beard, G Skrtich, A Bagavathy, K Drapola, D Bryan-Morris, K Arnold, J Reynolds, B Hussain, M Dunsavage, J Saiyed, S Hernandez, E Goldman, J Brown, C Comp, S Raczek, J Morris, J Vargas Jr., J Weiss, D Hensley, J Kochert, E Wnuk, C Nemeth, C Mowery, B Hutchinson, C Winters, L McAdams, D Walker, G Minnier, T Wisniewski, M Mayak, K McCreary, E Martin, E 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Campbell, A Garton, M Watkins, C Smuts, S Quinn, A Simpson, B McMillan, C Finch, C Hill, C Cooper, J Budd, J Small, C O’Leary, R Birch, J Collins, E Holland, A Alexander, P Felton, T Ferguson, S Sellers, K Ward, L Yates, D Birkinshaw, I Kell, K Scott, Z Pearson, H Hashmi, M Ali, M Hassan, N Panjwani, A Umrani, Z Shaikh, M Siddiqui, A Ain, Q Kanwal, D Van Bree, S Bouw-Ruiter, M Osinga, M Van Zanten, A McEldrew, R Rashan, S Singh, V Azergui, N Bari, S Beltran, M Brugman, C Groeneveld, E Jafarzadeh, M Keijzer-Timmers, N Kester, E Koelink, M Kwakkenbos-Craanen, M Okundaye, C Parker, L Peters, S Post, S Rietveld, I Scheepstra-Beukers, I Schreuder, G Smit, A Brillinger, N Markgraf, R Eichinger, F Doran, P Anjum, A Best-Lane, J Barton, F Miller, L Peters, S Richards-Belle, A Saull, M Sprinckmoller, S Wiley, D Darnell, R Au, C Lindstrum, K Cheng, A Forbes, A Heritier, S Trapani, T Cuthbertson, B Manoharan, V Dondrop, A Jayakumar, D Tolppa, T Ehrmann, S Hullegie, S Povoa, P Beasley, R Daneman, N Fowler, R McGloughlin, S Paterson, D Venkatesh, B De Jong, M Uyeki, T Baillie, K Hashmi, M Netea, M Orr, K Patanwala, A Tong, S Cooper, N Galea, J Leavis, H Ogungbenro, K Patawala, A Rademaker, E Tong, S Youngstein, T Carrier, M Fergusson, D Hunt, B Kumar, A Laffan, M Lother, S Middeldorp, S Stanworth, S De Man, A Masse, M-H Abraham, J Arnold, D Begin, P Charlewood, R Chasse, M Cooper, J Coyne, M Daly, J Gosbell, I Harvala-Simmonds, H MacLennan, S McDyer, J Menon, D Pridee, N Roberts, D Thomas, H Tinmouth, A Triulzi, D Walsh, T Wood, E Calfee, C O’Kane, C Shyamsundar, M Sinha, P Thompson, T Young, I Burrell, A Ferguson, N Hodgson, C Orford, N Phua, J Baron, R Epelman, S Frankfurter, C Gommans, F Kim, E Leaf, D Vaduganathan, M Van Kimmenade, R Sanil, A Van Beurden, M Effelaar, E Schotsman, J Boyd, C Harland, C Shearer, A Wren, J Clermont, G Ricketts, D Attanayaka, U Darshana, S Ishani, P Udayanga, I Higgins, AM Berry, LR Lorenzi, E Murthy, S McQuilten, Z Mouncey, PR Al-Beidh, F Annane, D Arabi, YM Beane, A Van Bentum-Puijk, W Bhimani, Z Bonten, MJM Bradbury, CA Brunkhorst, FM Burrell, A Buzgau, A Buxton, M Charles, WN Cove, M Detry, MA Estcourt, LJ Fagbodun, EO Fitzgerald, M Girard, TD Goligher, EC Goossens, H Haniffa, R Hills, T Horvat, CM Huang, DT Ichihara, N Lamontagne, F Marshall, JC McAuley, DF McGlothlin, A McGuinness, SP McVerry, BJ Neal, MD Nichol, AD Parke, RL Parker, JC Parry-Billings, K Peters, SEC Reyes, LF Rowan, KM Saito, H Santos, MS Saunders, CT Serpa-Neto, A Seymour, CW Shankar-Hari, M Stronach, LM Turgeon, AF Turner, AM Van de Veerdonk, FL Zarychanski, R Green, C Lewis, RJ Angus, DC McArthur, CJ Berry, S Derde, LPG Gordon, AC Webb, SA Lawler, PR |
| Item Type: | Journal Article |
| Abstract: | Importance The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. Objective To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. Design, Setting, and Participants Prespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022. Interventions Patients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401). Main Outcomes and Measures The main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83. Results Among 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies. Conclusions and Relevance Among critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months. |
| Issue Date: | 1-Jan-2023 |
| Date of Acceptance: | 30-Nov-2022 |
| URI: | http://hdl.handle.net/10044/1/101400 |
| DOI: | 10.1001/jama.2022.23257 |
| ISSN: | 0098-7484 |
| Publisher: | American Medical Association |
| Start Page: | 39 |
| End Page: | 51 |
| Journal / Book Title: | JAMA: Journal of the American Medical Association |
| Volume: | 329 |
| Issue: | 1 |
| Copyright Statement: | © 2022 American Medical Association. All rights reserved. |
| Publication Status: | Published |
| Online Publication Date: | 2022-12-16 |
| Appears in Collections: | Department of Surgery and Cancer Imperial College London COVID-19 |