Seasonal changes in the incidence of Escherichia coli bloodstream infection: variation with region and place of onset
File(s)
Accepted version
Supporting information
Author(s)
Deeny, SRM
van Kleef, E
Bou-Antoun, S
Hope, RJ
Robotham, JV
Type
Journal Article
Abstract
Previous research has shown that Escherichia coli infection rates peak in the summer, however to date there has been no investigation as to whether this is seen in both hospital and community-onset cases and how this differs across regions. We investigated and quantified E. coli bloodstream infection (BSI) seasonality. A generalized additive Poisson model was fitted to mandatory E. coli BSI surveillance data reported in England. There was no impact of seasonality in hospital-onset cases, however for the community onset cases there was statistically significant seasonal variation over time nationally. When examined regionally, seasonality was significant in the North of England only. This variation resulted in an absolute increase of 0.06 (95% CI, 0.04-0.08) cases above the mean (3.2) in each hospital trust for each week of the peak summer season and a decrease of 0.08 (-0.1, -0.06) in the autumn. We estimate that less than one hospital bed day per week, per hospital, is lost due to seasonal increases during the summer. Our findings highlight the need to understand distinct community and hospital dynamics of E. coli BSI and explore the regional differences driving variation in incidence in order to design and implement effective control measures.
Date Issued
2015-06-30
Date Acceptance
2015-06-23
Citation
Clinical Microbiology and Infection, 2015, 21 (10), pp.924-929
ISSN
1469-0691
Publisher
Elsevier
Start Page
924
End Page
929
Journal / Book Title
Clinical Microbiology and Infection
Volume
21
Issue
10
Copyright Statement
© 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Publication Status
Published