Cancer prevention through weight control-where are we in 2020?
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Accepted version
Accepted version
Author(s)
Type
Journal Article
Abstract
Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as a cost-effective approach for reducing the cancer burden. However, clear gaps remain in our understanding of how changes in body fat or levels of physical activity are mechanistically linked to cancer, and the magnitude of their impact on cancer risk. It is important to investigate the causal link between programmes that successfully achieve short-term modest weight loss followed by weight-loss maintenance and cancer incidence. The longer-term impact of weight loss and duration of overweight and obesity on risk reduction also need to be fully considered in trial design. These gaps in knowledge need to be urgently addressed to expedite the development and implementation of future cancer-control strategies. Comprehensive approaches to trial design, Mendelian randomisation studies and data-linkage opportunities offer real possibilities to tackle current research gaps. In this paper, we set out the case for why non-pharmacological weight-management trials are urgently needed to support cancer-risk reduction and help control the growing global burden of cancer.
Date Issued
2020-11-25
Date Acceptance
2020-10-22
Citation
British Journal of Cancer, 2020, 124, pp.1049-1056
ISSN
0007-0920
Publisher
Springer Nature [academic journals on nature.com]
Start Page
1049
End Page
1056
Journal / Book Title
British Journal of Cancer
Volume
124
Copyright Statement
© Cancer Research UK 2020. The final publication is available at Springer via https://doi.org/10.1038/s41416-020-01154-3
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000599063400003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
BODY-MASS INDEX
LIFE-STYLE INTERVENTION
PHYSICAL-ACTIVITY
BREAST-CANCER
MENDELIAN RANDOMIZATION
POSTMENOPAUSAL WOMEN
INSULIN-RESISTANCE
COLORECTAL-CANCER
RISK-FACTORS
EXERCISE
Publication Status
Published
Date Publish Online
2020-11-25