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Accelerated long-term forgetting can become apparent within 3-8 hours of wakefulness in patients with transient epileptic amnesia
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Accelerated long-term forgetting can become apparent within 3-8 hours of wakefulness in patients with transient epileptic am.pdf | Published version | 200.14 kB | Adobe PDF | View/Open |
Title: | Accelerated long-term forgetting can become apparent within 3-8 hours of wakefulness in patients with transient epileptic amnesia |
Authors: | Hoefeijzers, S Dewar, M Della Sala, S Butler, C Zeman, A |
Item Type: | Journal Article |
Abstract: | Objective: Accelerated long-term forgetting (ALF) is typically defined as a memory disorder in which information that is learned and retained normally over standard intervals (∼30 min) is forgotten at an abnormally rapid rate thereafter. ALF has been reported, in particular, among patients with transient epileptic amnesia (TEA). Previous work in TEA has revealed ALF 24 hr - 1 week after initial memory acquisition. It is unclear, however, if ALF observed 24 hr after acquisition reflects (a) an impairment of sleep consolidation processes taking place during the first night’s sleep, or (b) an impairment of daytime consolidation processes taking place during the day of acquisition. Here we focus on the daytime-forgetting hypothesis of ALF in TEA by tracking in detail the time course of ALF over the day of acquisition, as well as over 24 hr and 1 week. Method: Eleven TEA patients who showed ALF at 1 week and 16 matched controls learned 4 categorical word lists on the morning of the day of acquisition. We subsequently probed word-list retention 30 min, 3 hr, and 8 hr postacquisition (i.e., over the day of acquisition), as well as 24-hr and 1-week post acquisition. Results: ALF became apparent in the TEA group over the course of the day of acquisition 3–8 hr after learning. No further forgetting was observed over the first night in either group. Conclusions: The results of this study show that ALF in TEA can result from a deficit in memory consolidation occurring within hours of learning without a requirement for intervening sleep. |
Issue Date: | 1-Jan-2015 |
Date of Acceptance: | 9-May-2014 |
URI: | http://hdl.handle.net/10044/1/91190 |
DOI: | 10.1037/neu0000114 |
ISSN: | 0894-4105 |
Publisher: | American Psychological Association |
Start Page: | 117 |
End Page: | 125 |
Journal / Book Title: | Neuropsychology |
Volume: | 29 |
Issue: | 1 |
Copyright Statement: | © 2014 The Author(s). This article has been published under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the American Psychological Association the exclusive right to publish the article and identify itself as the original publisher. |
Keywords: | Social Sciences Science & Technology Life Sciences & Biomedicine Psychology, Clinical Neurosciences Psychology Neurosciences & Neurology accelerated long-term forgetting transient epileptic amnesia memory consolidation epilepsy TEMPORAL-LOBE EPILEPSY MEMORY CONSOLIDATION RECALL INTERFERENCE ASSOCIATION IMPAIRMENT INSIGHTS SLEEP AGE Adult Amnesia Epilepsy Female Humans Learning Male Memory Memory Disorders Mental Recall Neuropsychological Tests Sleep Time Factors Wakefulness Humans Epilepsy Memory Disorders Amnesia Learning Memory Mental Recall Wakefulness Sleep Neuropsychological Tests Time Factors Adult Female Male Social Sciences Science & Technology Life Sciences & Biomedicine Psychology, Clinical Neurosciences Psychology Neurosciences & Neurology accelerated long-term forgetting transient epileptic amnesia memory consolidation epilepsy TEMPORAL-LOBE EPILEPSY MEMORY CONSOLIDATION RECALL INTERFERENCE ASSOCIATION IMPAIRMENT INSIGHTS SLEEP AGE Experimental Psychology 1109 Neurosciences 1701 Psychology 1702 Cognitive Sciences |
Publication Status: | Published |
Online Publication Date: | 2014-08-04 |
Appears in Collections: | Department of Brain Sciences |
This item is licensed under a Creative Commons License