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Aggressive multiple sclerosis (1): Towards a definition of the phenotype.

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Title: Aggressive multiple sclerosis (1): Towards a definition of the phenotype.
Authors: Iacobaeus, E
Arrambide, G
Amato, MP
Derfuss, T
Vukusic, S
Hemmer, B
Tintore, M
Brundin, L
2018 ECTRIMS Focused Workshop Group
Item Type: Journal Article
Abstract: While the major phenotypes of multiple sclerosis (MS) and relapsing-remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. The current lack of an accepted definition and treatment guidelines for aggressive MS triggered a 2018 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) on aggressive MS. The aim of the workshop was to discuss approaches on how to describe and define the disease phenotype and its treatments. Unfortunately, it was not possible to come to consensus on a definition because of unavailable data correlating severe disease with imaging and molecular biomarkers. However, the workshop highlighted the need for future research needed to define this disease subtype while also focusing on its treatment and management. Here, we review previous attempts to define aggressive MS and present characteristics that might, with additional research, eventually help characterize it. A companion paper summarizes data regarding treatment and management.
Issue Date: 1-Aug-2020
Date of Acceptance: 16-Apr-2020
URI: http://hdl.handle.net/10044/1/90741
DOI: 10.1177/1352458520925369
ISSN: 1352-4585
Publisher: SAGE Publications
Start Page: 1031
End Page: 1044
Journal / Book Title: Multiple Sclerosis Journal
Volume: 26
Issue: 6
Copyright Statement: © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: Aggressive
disability
highly active
multiple sclerosis
observational studies
relapsing/remitting
2018 ECTRIMS Focused Workshop Group
Aggressive
disability
highly active
multiple sclerosis
observational studies
relapsing/remitting
1103 Clinical Sciences
1109 Neurosciences
Neurology & Neurosurgery
Publication Status: Published
Conference Place: England
Online Publication Date: 2020-06-12
Appears in Collections:Department of Brain Sciences



This item is licensed under a Creative Commons License Creative Commons