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Aggressive multiple sclerosis (1): Towards a definition of the phenotype.
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Aggressive multiple sclerosis (1) Towards a definition of the phenotype.pdf | Published version | 930.33 kB | Adobe PDF | View/Open |
Title: | Aggressive multiple sclerosis (1): Towards a definition of the phenotype. |
Authors: | Iacobaeus, E Arrambide, G Amato, MP Derfuss, T Vukusic, S Hemmer, B Tintore, M Brundin, L 2018 ECTRIMS Focused Workshop Group |
Item Type: | Journal Article |
Abstract: | While the major phenotypes of multiple sclerosis (MS) and relapsing-remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. The current lack of an accepted definition and treatment guidelines for aggressive MS triggered a 2018 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) on aggressive MS. The aim of the workshop was to discuss approaches on how to describe and define the disease phenotype and its treatments. Unfortunately, it was not possible to come to consensus on a definition because of unavailable data correlating severe disease with imaging and molecular biomarkers. However, the workshop highlighted the need for future research needed to define this disease subtype while also focusing on its treatment and management. Here, we review previous attempts to define aggressive MS and present characteristics that might, with additional research, eventually help characterize it. A companion paper summarizes data regarding treatment and management. |
Issue Date: | 1-Aug-2020 |
Date of Acceptance: | 16-Apr-2020 |
URI: | http://hdl.handle.net/10044/1/90741 |
DOI: | 10.1177/1352458520925369 |
ISSN: | 1352-4585 |
Publisher: | SAGE Publications |
Start Page: | 1031 |
End Page: | 1044 |
Journal / Book Title: | Multiple Sclerosis Journal |
Volume: | 26 |
Issue: | 6 |
Copyright Statement: | © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
Keywords: | Aggressive disability highly active multiple sclerosis observational studies relapsing/remitting 2018 ECTRIMS Focused Workshop Group Aggressive disability highly active multiple sclerosis observational studies relapsing/remitting 1103 Clinical Sciences 1109 Neurosciences Neurology & Neurosurgery |
Publication Status: | Published |
Conference Place: | England |
Online Publication Date: | 2020-06-12 |
Appears in Collections: | Department of Brain Sciences |
This item is licensed under a Creative Commons License