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3D printed porous methacrylate/silica hybrid scaffold for bone substitution

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Title: 3D printed porous methacrylate/silica hybrid scaffold for bone substitution
Authors: Chung, JJ
Yoo, J
Sum, BST
Li, S
Lee, S
Kim, TH
Li, Z
Stevens, MM
Georgiou, TK
Jung, Y
Jones, JR
Item Type: Journal Article
Abstract: Inorganic–organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica, which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of the sol. Three different inorganic:organic ratios of poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate)-star-SiO2 hybrid inks are printed with pore channels in the range of 100–200 µm. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre-osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Osteogenic and angiogenic properties of the hybrid scaffolds are shown using a rat calvarial defect model. Hybrid scaffolds with 40:60 inorganic:organic composition are able to instigate new vascularized bone formation within its pore channels and polarize macrophages toward M2 phenotype. 3D printing inorganic–organic hybrids with sophisticated polymer structure opens up possibilities to produce novel bone graft materials.
Issue Date: 23-Jun-2021
Date of Acceptance: 1-May-2021
URI: http://hdl.handle.net/10044/1/88824
DOI: 10.1002/adhm.202100117
ISSN: 2192-2640
Publisher: Wiley-VCH Verlag
Start Page: 1
End Page: 13
Journal / Book Title: Advanced Healthcare Materials
Volume: 10
Issue: 12
Copyright Statement: © 2021 The Authors. Advanced Healthcare Materials published by Wiley‐VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/R015651/1
Keywords: Science & Technology
Technology
Engineering, Biomedical
Nanoscience & Nanotechnology
Materials Science, Biomaterials
Engineering
Science & Technology - Other Topics
Materials Science
3D printing
biomaterials
bone substitutes
hybrids
sol‐
gels
3D printing
biomaterials
bone substitutes
hybrids
sol-gels
Science & Technology
Technology
Engineering, Biomedical
Nanoscience & Nanotechnology
Materials Science, Biomaterials
Engineering
Science & Technology - Other Topics
Materials Science
3D printing
biomaterials
bone substitutes
hybrids
sol‐
gels
0304 Medicinal and Biomolecular Chemistry
0903 Biomedical Engineering
1004 Medical Biotechnology
Publication Status: Published
Open Access location: https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100117
Article Number: ARTN 2100117
Online Publication Date: 2021-05-05
Appears in Collections:Materials
Faculty of Natural Sciences
Faculty of Engineering



This item is licensed under a Creative Commons License Creative Commons