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3D printed porous methacrylate/silica hybrid scaffold for bone substitution
File | Description | Size | Format | |
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adhm.202100117.pdf | Published version | 4.53 MB | Adobe PDF | View/Open |
Title: | 3D printed porous methacrylate/silica hybrid scaffold for bone substitution |
Authors: | Chung, JJ Yoo, J Sum, BST Li, S Lee, S Kim, TH Li, Z Stevens, MM Georgiou, TK Jung, Y Jones, JR |
Item Type: | Journal Article |
Abstract: | Inorganic–organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica, which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of the sol. Three different inorganic:organic ratios of poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate)-star-SiO2 hybrid inks are printed with pore channels in the range of 100–200 µm. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre-osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Osteogenic and angiogenic properties of the hybrid scaffolds are shown using a rat calvarial defect model. Hybrid scaffolds with 40:60 inorganic:organic composition are able to instigate new vascularized bone formation within its pore channels and polarize macrophages toward M2 phenotype. 3D printing inorganic–organic hybrids with sophisticated polymer structure opens up possibilities to produce novel bone graft materials. |
Issue Date: | 23-Jun-2021 |
Date of Acceptance: | 1-May-2021 |
URI: | http://hdl.handle.net/10044/1/88824 |
DOI: | 10.1002/adhm.202100117 |
ISSN: | 2192-2640 |
Publisher: | Wiley-VCH Verlag |
Start Page: | 1 |
End Page: | 13 |
Journal / Book Title: | Advanced Healthcare Materials |
Volume: | 10 |
Issue: | 12 |
Copyright Statement: | © 2021 The Authors. Advanced Healthcare Materials published by Wiley‐VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Sponsor/Funder: | Medical Research Council (MRC) |
Funder's Grant Number: | MR/R015651/1 |
Keywords: | Science & Technology Technology Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science 3D printing biomaterials bone substitutes hybrids sol‐ gels 3D printing biomaterials bone substitutes hybrids sol-gels Science & Technology Technology Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science 3D printing biomaterials bone substitutes hybrids sol‐ gels 0304 Medicinal and Biomolecular Chemistry 0903 Biomedical Engineering 1004 Medical Biotechnology |
Publication Status: | Published |
Open Access location: | https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100117 |
Article Number: | ARTN 2100117 |
Online Publication Date: | 2021-05-05 |
Appears in Collections: | Materials Faculty of Natural Sciences Faculty of Engineering |
This item is licensed under a Creative Commons License