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A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

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Title: A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
Authors: Rao, KU
Henderson, DI
Krishnan, N
Puthia, M
Glegola-Madejska, I
Brive, L
Bjarnemark, F
Fureby, AM
Hjort, K
Andersson, DI
Tenland, E
Sturegard, E
Robertson, BD
Godaly, G
Item Type: Journal Article
Abstract: Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in a murine TB-model. In vivo, the peptide remained stable in circulation and preserved lung structure better than ethambutol alone. Antibiotic resistance studies did not induce mutants with reduced susceptibility to the peptide. We further observed that this peptide was effective against nontuberculous mycobacteria (NTM), such as M. avium and M. abscessus, and several Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In conclusion, the presented data supports a role for this CHDP in the treatment of drug resistant organisms.
Issue Date: 18-Feb-2021
Date of Acceptance: 8-Feb-2021
URI: http://hdl.handle.net/10044/1/87879
DOI: 10.1038/s41598-021-83755-3
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 11
Issue: 1
Copyright Statement: © 2021 The Authors. Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Publication Status: Published
Open Access location: https://doi.org/10.1038/s41598-021-83755-3
Article Number: 4201
Online Publication Date: 2021-02-18
Appears in Collections:Department of Infectious Diseases



This item is licensed under a Creative Commons License Creative Commons