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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
| File | Description | Size | Format | |
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 Nrf2-interacting nutrients and COVID-19 time for research to develop adaptation strategies.pdf | Published version | 1.65 MB | Adobe PDF | View/Open |
| Title: | Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies |
| Authors: | Bousquet, J Cristol, J-P Czarlewski, W Anto, JM Martineau, A Haahtela, T Fonseca, SC Iaccarino, G Blain, H Fiocchi, A Canonica, GW Fonseca, JA Vidal, A Choi, H-J Kim, HJ Le Moing, V Reynes, J Sheikh, A Akdis, CA Zuberbier, T Abdul Latiff, AH Abdullah, B Aberer, W Abusada, N Adcock, I Afani, A Agache, I Aggelidis, X Agustin, J Akdis, CA Akdis, M Al-Ahmad, M Al-Zahab Bassam, A Alburdan, H Aldrey-Palacios, O Alvarez Cuesta, E Alwan Salman, H Alzaabi, A Amade, S Ambrocio, G Angles, R Annesi-Maesano, I Ansotegui, IJ Anto, JM Ara Bardajo, P Arasi, S Arrais, M Arshad, H Artesani, M-C Asayag, E Avolio, F Azhari, K Bachert, C Bagnasco, D Baiardini, I Bajrovic, N Bakakos, P Bakeyala Mongono, S Balotro-Torres, C Barba, S Barbara, C Barbosa, E Barreto, B Bartra, J Basagana, X Bateman, ED Battur, L Bedbrook, A Bedolla Barajas, M Beghe, B Bekere, A Bel, E Ben Kheder, A Benson, M Berghea, E-C Bergmann, K-C Bernardini, R Bernstein, D Bewick, M Bialek, S Bialoszewski, A Bieber, T Billo, NE Bilo, M-B Bindslev-Jensen, C Bjermer, L Blain, H Bobolea, I Bochenska Marciniak, M Bond, C Boner, A Bonini, M Bonini, S Bosnic-Anticevich, S Bosse, I Botskariova, S Bouchard, J Boulet, L-P Bourret, R Bousquet, P Braido, F Briggs, A Brightling, CE Brozek, J Brussino, L Buhl, R Bumbacea, R Buquicchio, R Burguete Cabanas, M-T Bush, A Busse, WW Buters, J Caballero-Fonseca, F Calderon, MA Calvo, M Camargos, P Camuzat, T Canevari, FR Cano, A Canonica, GW Capriles-Hulett, A Caraballo, L Cardona, V Carlsen, K-H Carmona Pirez, J Caro, J Carr, W Carreiro-Martins, P Carreon-Asuncion, F Carriazo, A-M Carrion y Ribas, C Casale, T Castor, M-A Castro, E Caviglia, AG Cecchi, L Cepeda Sarabia, A Chalubinski, M Chandrasekharan, R Chang, Y-S Chato-Andeza, V Chatzi, L Chatzidaki, C Chavannes, NH Chaves Loureiro, C Chavez Garcia, A-A Chelninska, M Chen, Y Cheng, L Chinthrajah, S Chivato, T Chkhartishvili, E Christoff, G Chrystyn, H Chu, DK Chua, A Chuchalin, A Chung, KF Ciceran, A Cingi, C Ciprandi, G Cirule, I Coelho, A-C Compalati, E Constantinidis, J Correia de Sousa, J Costa, EM Costa, D Del Carmen Costa Dominguez, M Coste, A Cottini, M Cox, L Crisci, C Crivellaro, MA Cruz, AA Cullen, J Custovic, A Cvetkovski, B Czarlewski, W D'Amato, G Da Silva, J Dahl, R Dahlen, S-E Daniilidis, V Darjazini Nahhas, L Darsow, U Davies, J De Blay, F De Feo, G De Guia, E De la Torre Navarrete, J-R De los Santos, C De Manuel Keenoy, E De Vries, G Deleanu, D Demoly, P Denburg, J Devillier, P Didier, A Dimic Janjic, S Dimou, M Dinh-Xuan, AT Djukanovic, R Do Ceu Texeira, M Dokic, D Dominguez Silva, MG Douagui, H Douladiris, N Doulaptsi, M Dray, G Dubakiene, R Dupas, E Durham, S Duse, M Dykewicz, M Ebo, D Edelbaher, N Eiwegger, T Eklund, P El-Gamal, Y El-Sayed, ZA El-Sayed, SS El-Seify, M Emuzyte, R Enecilla, L Erhola, M Espinoza, H Espinoza Contreras, JG Farrell, J Fernandez, L Fimbres Jimenez, P Fink Wagner, A Fiocchi, A Fokkens, WJ Folletti, L Fonseca, JA Fontaine, J-F Forastiere, F Fuentes Perez, JM Gaerlan-Resureccion, E Gaga, M Galvez Romero, JL Gamkrelidze, A Garcia, A Garcia Cobas, CY De la Luz Hortensia Garcia Cruz, M Ortiz, VG Gayraud, J Gelardi, M Gemicioglu, B Gennimata, D Genova, S Gereda, J Gerth van Wijk, R Giuliano, A Gomez, R-M Gonzalez Ballester, M-A Gonzalez Diaz, S Gotua, M Grigoreas, C Grisle, I Guidacci, M Guldemond, N Gutter, Z Guzman, A Haahtela, T Halloum, R Halpin, D Hamelmann, E Hammadi, S Harvey, R Heffler, E Heinrich, J Hejjaoui, A Hellquist-Dahl, B Hernandez Velazquez, L Hew, M Hossny, E Howarth, P Hrubisko, M Huerta Villalobos, YR Humbert, M Husain, S Hyland, M Iaccarino, G Ibrahim, M Ilina, N Illario, M Incorvaia, C Infantino, A Irani, C Ispayeva, Z Ivancevich, JC Jares, EEJ Jarvis, D Jassem, E Jenko, K Jimeneracruz Uscanga, RD Johnston, SL Joos, G Jost, M Julge, K Jung, K-S Just, J Jutel, M Kaidashev, I Kalayci, O Kalyoncu, F Kapsali, J Kardas, P Karjalainen, J Kasala, CA Katotomichelakis, M Kavaliukaite, L Bennoor, KS Keil, T Keith, P Khaitov, M Khaltaev, N Kim, Y-Y Kirenga, B Kleine-Tebbe, J Klimek, L Ko, FW Koffi N'Goran, B Kompoti, E Kopac, P Koppelman, G Koren Jeverica, A Koskinen, S Kosnik, M Kostka, T Kostov, KV Kowalski, ML Kralimarkova, T Kramer Vrscaj, K Kraxner, H Kreft, S Kritikos, V Kudlay, D Kuitunen, M Kull, I Kuna, P Kupczyk, M Kvedariene, V Kyriakakou, M Lalek, N Landi, M Lane, S Larenas-Linnemann, DE Lau, S Laune, D Lavrut, J Le, L Lenzenhuber, M Leo, G Lessa, M Levin, M Li, J Lieberman, P Liotta, G Lipworth, B Liu, X Lobo, R Lodrup Carlsen, KC Lombardi, C Louis, R Loukidis, S Lourenco, O Luna Pech, JA Madjar, B Maggi, E Magnan, A Mahboub, B Mair, A Maitland van der Zee, A-H Makela, M Makris, M Malling, H-J Mandajieva, M Manning, P Manousakis, M Maragoudakis, P Marseglia, G Marshall, G Masjedi, MR Maspero, JF Matta Campos, JJ Maurer, M Mavale-Manuel, S Meco, C Melen, E Melioli, G Melo-Gomes, E Meltzer, EO Menditto, E Menzies-Gow, A Merk, H Michel, J-P Micheli, Y Miculinic, N Midao, L Mihaltan, F Mikos, N Milanese, M Milenkovic, B Mitsias, D Moalla, B Moda, G Mogica Martinez, MD Mohammad, Y Moharra, F-M Moin, M Molimard, M Momas, I Mommers, M Monaco, A Montefort, S Montenegro, L-E Monti, R Mora, D Morais-Almeida, M Mosges, R Mostafa, BE Mullol, J Munter, L Muraro, A Murray, R Musarra, A Mustakov, T Naclerio, R Nadeau, KC Nadif, R Nakonechna, A Namazova-Baranova, L Navarro-Locsin, G Neffen, H Nekam, K Neou, A Nettis, E Neuberger, D Nicod, L Nicola, S Niederberger-Leppin, V Niedoszytko, M Nieto, A Novellino, E Nunes, E Nyembue, D O'Hehir, RE Odjakova, C Ohta, K Okamoto, Y Okubo, K Oliver, B Onorato, GL Orru, MP Ouedraogo, S Ouoba, K Padilla, F-J Paggiaro, PL Pagkalos, A Pajno, G Pala, G Palaniappan, SP Pali-Scholl, I Palkonen, S Palmer, S Panaitescu Bunu, C Panzner, P Papadopoulos, NG Papanikolaou, V Papi, A Paralchev, B Paraskevopoulos, G Park, H-S Passalacqua, G Patella, V Pavord, I Pawankar, R Pedersen, S Peleve, S Pellegino, S Pereira, A Pereira, M Perez, T Perna, A Peroni, D Pfaar, O Pham-Thi, N Pigearias, B Pin, I Piskou, K Pitsios, C Plavec, D Poethig, D Pohl, W Poplas Susic, A Popov, TA Portejoie, F Potter, P Poulsen, L Prados-Torres, A Prarros, F Price, D Prokopakis, E Puggioni, F Puig-Domenech, E Puy, R Rabe, K Rabotti, S Raciborski, F Ramos, J Recalcati, C Recto, MT Reda, SM Regateiro, FS Reider, N Reitsma, S Repka-Ramirez, S Ridolo, E Rimmer, J Rivero Yeverino, D Rizzo, JA Robalo-Cordeiro, C Roberts, G Robles, K Roche, N Rodriguez Gonzalez, M Rodriguez Zagal, E Rolla, G Rolland, C Roller-Wirnsberger, R Roman Rodriguez, M Romano, A Romantowski, J Rombaux, P Romualdez, J Rosado-Pinto, J Rosario, N Rosenwasser, L Rossi, O Rottem, M Rouadi, PW Rovina, N Rozman Sinur, I Ruiz, M Ruiz Segura, LT Ryan, D Sagara, H Sakai, D Sakurai, D Saleh, W Salimaki, J Samitas, K Samolinski, B Sanchez Coronel, MG Sanchez-Borges, M Sanchez-Lopez, J Sansonna, M Sarafoleanu, C Sarquis Serpa, F Sastre, J Savi, E Savonyte, A Sawaf, B Scadding, GK Scheire, S Schmid-Grendelmeier, P Schuhl, JF Schunemann, H Schvalbova, M Schwarze, J Scichilone, N Senna, G Sepulveda, C Serrano, E Shamai, S Sheikh, A Shields, M Shishkov, V Siafakas, N Simeonov, A Simons, EFER Sisul, JC Sitkauskiene, B Skrindo, I Soklic Kosak, T Sole, D Sondermann, M Sooronbaev, T Soto-Martinez, M Soto-Quiros, M Pinto, BS Sova, M Soyka, M Specjalski, K Sperl, A Spranger, O Stamataki, S Stefanaki, L Stellato, C Stelmach, R Strandberg, T Stute, P Subramaniam, A Suppli Ulrik, C Sutherland, M Sylvestre, S Syrigou, A Taborda Barata, L Takovska, N Tan, R Tan, F Tan, V Tang, IP Taniguchi, M Tannert, L Tantilipikorn, P Tattersall, J Tesi, F Thieme, U Thijs, C Thomas, M To, T Todo-Bom, AM Togias, A Tomazic, P-V Tomic-Spiric, V Toppila-Salmi, S Torres Jaen, M-J Toskala, E Triggiani, M Triller, N Triller, K Tsiligianni, I Uberti, M Ulmeanu, R Urbancic, J Urrutia Pereira, M Vachova, M Valdes, F Valenta, R Valentin Rostan, M Valero, A Valiulis, A Vallianatou, M Valovirta, E Van Eerd, M Van Ganse, E Van Hage, M Vandenplas, O Vasankari, T Vassileva, D Velasco Munoz, C Ventura, MT Vera-Munoz, C Viart, F Vicheva, D Vichyanond, P Vidgren, P Viegi, G Vogelmeier, C Von Hertzen, L Vontetsianos, T Vourdas, D Tran Thien Quan, V Wagenmann, M Walker, S Wallace, D De Wang, Y Waserman, S Wehner, K Wickman, M Williams, S Williams, D Wilson, N Wong, G Woo, K Wozniak, L Wright, J Wroczynski, P Xepapadaki, P Yakovliev, P Yamaguchi, M Yan, K Yap, YY Yassin, M Yawn, B Yiallouros, P Yorgancioglu, A Yoshihara, S Young, I Yusuf, OB Zaidi, A Zaitoun, F Zalud, P Zar, H Zedda, MT Zernotti, ME Zhang, L Zhong, N Zidarn, M Zuberbier, T Zubrinich, C |
| Item Type: | Journal Article |
| Abstract: | There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity. |
| Issue Date: | 3-Dec-2020 |
| Date of Acceptance: | 12-Nov-2020 |
| URI: | http://hdl.handle.net/10044/1/85651 |
| DOI: | 10.1186/s13601-020-00362-7 |
| ISSN: | 2045-7022 |
| Publisher: | BioMed Central |
| Start Page: | 1 |
| End Page: | 18 |
| Journal / Book Title: | Clinical and Translational Allergy |
| Volume: | 10 |
| Issue: | 1 |
| Copyright Statement: | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativeco mmons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Keywords: | Science & Technology Life Sciences & Biomedicine Allergy COVID-19 Nrf2 Foods Nutrients Insulin resistance Obesity TRPA1 ENDOPLASMIC-RETICULUM STRESS NF-KAPPA-B ACUTE LUNG INJURY RESPIRATORY SYNDROME CORONAVIRUS MUSCLE-CELL PROLIFERATION OXIDATIVE STRESS INSULIN-RESISTANCE SIGNALING PATHWAY NRF2 ACTIVATORS SULFORAPHANE PROTECTS COVID-19 Foods Insulin resistance Nrf2 Nutrients Obesity TRPA1 ARIA group Science & Technology Life Sciences & Biomedicine Allergy COVID-19 Nrf2 Foods Nutrients Insulin resistance Obesity TRPA1 ENDOPLASMIC-RETICULUM STRESS NF-KAPPA-B ACUTE LUNG INJURY RESPIRATORY SYNDROME CORONAVIRUS MUSCLE-CELL PROLIFERATION OXIDATIVE STRESS INSULIN-RESISTANCE SIGNALING PATHWAY NRF2 ACTIVATORS SULFORAPHANE PROTECTS |
| Publication Status: | Published |
| Article Number: | ARTN 58 |
| Online Publication Date: | 2020-12-03 |
| Appears in Collections: | National Heart and Lung Institute Imperial College London COVID-19 |
This item is licensed under a Creative Commons License
