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25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk: a systematic review and dose-response meta-analysis of prospective studies
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25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk a systematic review and dose-response meta-analysis of pr.pdf | Published version | 1.74 MB | Adobe PDF | View/Open |
Title: | 25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk: a systematic review and dose-response meta-analysis of prospective studies |
Authors: | Mahamat-Saleh, Y Aune, D Schlesinger, S |
Item Type: | Journal Article |
Abstract: | Sun exposure is a major environmental risk factor for skin cancers and is also an important source of vitamin D. However, while experimental evidence suggests that vitamin D may have a protective effect on skin cancer risk, epidemiologic studies investigating the influence of 25-hydroxyvitamin D (25(OH)D) level and/or vitamin D intake on skin cancer risk are conflicting. A systematic review and dose–response meta-analyses of prospective studies was conducted to clarify these associations. Relevant studies were identified by searching the PubMed database up to 30th August 2019. Random effects dose–response meta-analyses were used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs). Overall, thirteen prospective studies were included. Circulating level of 25(OH)D was associated with higher risks of melanoma (SRR (95% CI) per 30 nmol = 1.42 (1.17–1.72)) and keratinocyte cancer (KC) (SRR (95% CI) per 30 nmol/L = 1.30 (1.13–1.49)). The SRR (95% CI) per 30 nmol/L increase in 25(OH) D level was 1.41 (1.19–1.67), and 1.57 (0.64–3.86), for basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs), respectively. However, while we found that vitamin D intake (from diet, supplemental and total) was not associated with risks of melanoma and SCC, vitamin D intake was associated with slightly increased BCC risk, albeit with no heterogeneity across skin cancer type. This meta-analysis suggests positive associations between circulating 25(OH)D level and risk of melanoma and KC, however, this finding is most likely confounded by sun exposure. We found no associations between vitamin D intake skin cancers, except positive associations with BCC risk. |
Issue Date: | 4-Aug-2020 |
Date of Acceptance: | 14-Jun-2020 |
URI: | http://hdl.handle.net/10044/1/85390 |
DOI: | 10.1038/s41598-020-70078-y |
ISSN: | 2045-2322 |
Publisher: | Nature Publishing Group |
Start Page: | 1 |
End Page: | 15 |
Journal / Book Title: | Scientific Reports |
Volume: | 10 |
Issue: | 1 |
Copyright Statement: | © The Author(s) 2020. Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics D-RECEPTOR POLYMORPHISMS CUTANEOUS MELANOMA SUN EXPOSURE INVERSE ASSOCIATION MALIGNANT-MELANOMA DNA-DAMAGE D LEVEL NONMELANOMA MORTALITY SURVIVAL Carcinoma, Basal Cell Dose-Response Relationship, Drug Humans Prospective Studies Risk Factors Skin Neoplasms Vitamin D Humans Carcinoma, Basal Cell Skin Neoplasms Vitamin D Risk Factors Prospective Studies Dose-Response Relationship, Drug Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics D-RECEPTOR POLYMORPHISMS CUTANEOUS MELANOMA SUN EXPOSURE INVERSE ASSOCIATION MALIGNANT-MELANOMA DNA-DAMAGE D LEVEL NONMELANOMA MORTALITY SURVIVAL |
Publication Status: | Published |
Article Number: | ARTN 13151 |
Online Publication Date: | 2020-08-04 |
Appears in Collections: | School of Public Health |
This item is licensed under a Creative Commons License