19
IRUS TotalDownloads
Altmetric
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia
| File | Description | Size | Format | |
|---|---|---|---|---|
 elife-63430-v2.pdf | Published version | 1.17 MB | Adobe PDF | View/Open |
| Title: | Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia |
| Authors: | Gregorova, M Morse, D Brignoli, T Steventon, J Hamilton, F Albur, M Arnold, D Thomas, M Halliday, A Baum, H Rice, C Avison, MB Davidson, AD Santopaolo, M Oliver, E Goenka, A Finn, A Wooldridge, L Amulic, B Boyton, RJ Altmann, DM Butler, DK McMurray, C Stockton, J Nicholls, S Cooper, C Loman, N Cox, MJ Rivino, L Massey, RC |
| Item Type: | Journal Article |
| Abstract: | Here we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes. |
| Issue Date: | 17-Dec-2020 |
| Date of Acceptance: | 16-Dec-2020 |
| URI: | http://hdl.handle.net/10044/1/85203 |
| DOI: | 10.7554/eLife.63430 |
| ISSN: | 2050-084X |
| Publisher: | eLife Sciences Publications Ltd |
| Journal / Book Title: | eLife |
| Volume: | 9 |
| Copyright Statement: | Copyright Gregorova et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| Sponsor/Funder: | Welton Foundation National Institutes of Health Biotechnology and Biological Sciences Research Council (BBSRC) Wellcome Trust Versus Arthritis Commission of the European Communities |
| Funder's Grant Number: | N/A HHSN272200900046C BB/H005439/1 100046/Z/12/Z 21135 860325 |
| Keywords: | human infectious disease microbiology human infectious disease microbiology 0601 Biochemistry and Cell Biology |
| Publication Status: | Published online |
| Conference Place: | England |
| Online Publication Date: | 2020-12-17 |
| Appears in Collections: | Department of Immunology and Inflammation Department of Infectious Diseases Imperial College London COVID-19 |
This item is licensed under a Creative Commons License
