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A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection.
| File | Description | Size | Format | |
|---|---|---|---|---|
 COVID HGE CELL[2].pdf | Accepted version | 957.56 kB | Adobe PDF | View/Open |
| Title: | A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection. |
| Authors: | Casanova, J-L Su, HC COVID Human Genetic Effort |
| Item Type: | Journal Article |
| Abstract: | SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease. |
| Issue Date: | 11-Jun-2020 |
| Date of Acceptance: | 1-May-2020 |
| URI: | http://hdl.handle.net/10044/1/82074 |
| DOI: | 10.1016/j.cell.2020.05.016 |
| ISSN: | 0092-8674 |
| Publisher: | Elsevier |
| Start Page: | 1194 |
| End Page: | 1199 |
| Journal / Book Title: | Cell |
| Volume: | 181 |
| Issue: | 6 |
| Copyright Statement: | 2020 © Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Sponsor/Funder: | UKRI Future Leader's Fellowship |
| Keywords: | Age Factors Betacoronavirus Coronavirus Infections Disease Resistance Genetic Association Studies Genetic Diseases, Inborn Genetic Predisposition to Disease Genetic Variation Genome, Human Host-Pathogen Interactions Humans Infections Pandemics Pneumonia, Viral COVID Human Genetic Effort Humans Pneumonia, Viral Coronavirus Infections Genetic Diseases, Inborn Genetic Predisposition to Disease Age Factors Genome, Human Host-Pathogen Interactions Genetic Variation Genetic Association Studies Pandemics Disease Resistance Betacoronavirus Infections Age Factors Betacoronavirus Coronavirus Infections Disease Resistance Genetic Association Studies Genetic Diseases, Inborn Genetic Predisposition to Disease Genetic Variation Genome, Human Host-Pathogen Interactions Humans Infections Pandemics Pneumonia, Viral 06 Biological Sciences 11 Medical and Health Sciences Developmental Biology |
| Publication Status: | Published |
| Conference Place: | United States |
| Online Publication Date: | 2020-05-13 |
| Appears in Collections: | Department of Infectious Diseases Imperial College London COVID-19 |
This item is licensed under a Creative Commons License
