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Hierarchical binding of copperII to N-truncated Aβ4-16 peptide
| File | Description | Size | Format | |
|---|---|---|---|---|
 Supporting Information_Teng_etal.pdf | Supporting information | 9.87 MB | Adobe PDF | View/Open |
| c9mt00299e.pdf | Published verison | 2.07 MB | Adobe PDF | View/Open |
| Title: | Hierarchical binding of copperII to N-truncated Aβ4-16 peptide |
| Authors: | Teng, X Stefaniak, E Girvan, P Płonka, D Bal, W Ying, L |
| Item Type: | Journal Article |
| Abstract: | N-Truncated Aβ4–42 displays a high binding affinity with CuII. A mechanistic scheme of the interactions between Aβ4–42 and CuII has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ4–42 during neurotransmission. |
| Issue Date: | 1-Apr-2020 |
| Date of Acceptance: | 18-Feb-2020 |
| URI: | http://hdl.handle.net/10044/1/78012 |
| DOI: | 10.1039/C9MT00299E |
| ISSN: | 1756-5901 |
| Publisher: | Royal Society of Chemistry |
| Start Page: | 470 |
| End Page: | 473 |
| Journal / Book Title: | Metallomics: integrated biometal science |
| Volume: | 12 |
| Issue: | 4 |
| Copyright Statement: | © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/) |
| Sponsor/Funder: | The Leverhulme Trust Biotechnology and Biological Sciences Research Council (BBSRC) |
| Funder's Grant Number: | RPG-2015-345 BB/R022429/1 |
| Keywords: | 03 Chemical Sciences Analytical Chemistry |
| Publication Status: | Published online |
| Online Publication Date: | 2020-04-01 |
| Appears in Collections: | Chemistry Faculty of Natural Sciences |