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Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives
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Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database reco.pdf | Published version | 663.76 kB | Adobe PDF | View/Open |
Title: | Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives |
Authors: | STARSurg Collaborative Nepogodiev, D |
Item Type: | Journal Article |
Abstract: | Background Trainee research collaboratives (TRCs) have pioneered high quality, prospective ‘snap-shot’ surgical cohort studies in the UK. Outcomes After Kidney injury in Surgery (OAKS) was the first TRC cohort study to attempt to collect one-year follow-up data. The aims of this study were to evaluate one-year follow-up and data completion rates, and to identify factors associated with improved follow-up rates. Methods In this multicentre study, patients undergoing major gastrointestinal surgery were prospectively identified and followed up at one-year following surgery for six clinical outcomes. The primary outcome for this report was the follow-up rate for mortality at 1 year. The secondary outcome was the data completeness rate in those patients who were followed-up. An electronic survey was disseminated to investigators to identify strategies associated with improved follow-up. Results Of the 173 centres that collected baseline data, 126 centres registered to participate in one-year follow-up. Overall 62.3% (3482/5585) of patients were followed-up at 1 year; in centres registered to collect one-year outcomes, the follow-up rate was 82.6% (3482/4213). There were no differences in sex, comorbidity, operative urgency, or 7-day postoperative AKI rate between patients who were lost to follow-up and those who were successfully followed-up. In centres registered to collect one-year follow-up outcomes, overall data completeness was 83.1%, with 57.9% (73/126) of centres having ≥95% data completeness. Factors associated with increased likelihood of achieving ≥95% data completeness were total number of patients to be followed-up (77.4% in centres with < 15 patients, 59.0% with 15–29 patients, 51.4% with 30–59 patients, and 36.8% with > 60 patients, p = 0.030), and central versus local storage of patient identifiers (72.5% vs 48.0%, respectively, p = 0.006). Conclusions TRC methodology can be used to follow-up patients identified in prospective cohort studies at one-year. Follow-up rates are maximized by central storage of patient identifiers. |
Issue Date: | 12-Dec-2019 |
Date of Acceptance: | 23-Oct-2019 |
URI: | http://hdl.handle.net/10044/1/77912 |
DOI: | 10.1186/s12874-019-0857-y |
ISSN: | 1471-2288 |
Publisher: | BioMed Central |
Start Page: | 1 |
End Page: | 7 |
Journal / Book Title: | BMC Medical Research Methodology |
Volume: | 19 |
Issue: | 1 |
Copyright Statement: | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Keywords: | Science & Technology Life Sciences & Biomedicine Health Care Sciences & Services Research collaborative Surgery Follow-up Methodology ACUTE KIDNEY INJURY SURGICAL RESEARCH MORTALITY SURGERY MULTICENTER IMPACT Follow-up Methodology Research collaborative Surgery STARSurg Collaborative Science & Technology Life Sciences & Biomedicine Health Care Sciences & Services Research collaborative Surgery Follow-up Methodology ACUTE KIDNEY INJURY SURGICAL RESEARCH MORTALITY SURGERY MULTICENTER IMPACT General & Internal Medicine 1117 Public Health and Health Services |
Publication Status: | Published |
Article Number: | ARTN 237 |
Online Publication Date: | 2019-12-12 |
Appears in Collections: | Central Faculty |