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Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives

Title: Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives
Authors: STARSurg Collaborative
Nepogodiev, D
Item Type: Journal Article
Abstract: Background Trainee research collaboratives (TRCs) have pioneered high quality, prospective ‘snap-shot’ surgical cohort studies in the UK. Outcomes After Kidney injury in Surgery (OAKS) was the first TRC cohort study to attempt to collect one-year follow-up data. The aims of this study were to evaluate one-year follow-up and data completion rates, and to identify factors associated with improved follow-up rates. Methods In this multicentre study, patients undergoing major gastrointestinal surgery were prospectively identified and followed up at one-year following surgery for six clinical outcomes. The primary outcome for this report was the follow-up rate for mortality at 1 year. The secondary outcome was the data completeness rate in those patients who were followed-up. An electronic survey was disseminated to investigators to identify strategies associated with improved follow-up. Results Of the 173 centres that collected baseline data, 126 centres registered to participate in one-year follow-up. Overall 62.3% (3482/5585) of patients were followed-up at 1 year; in centres registered to collect one-year outcomes, the follow-up rate was 82.6% (3482/4213). There were no differences in sex, comorbidity, operative urgency, or 7-day postoperative AKI rate between patients who were lost to follow-up and those who were successfully followed-up. In centres registered to collect one-year follow-up outcomes, overall data completeness was 83.1%, with 57.9% (73/126) of centres having ≥95% data completeness. Factors associated with increased likelihood of achieving ≥95% data completeness were total number of patients to be followed-up (77.4% in centres with < 15 patients, 59.0% with 15–29 patients, 51.4% with 30–59 patients, and 36.8% with > 60 patients, p = 0.030), and central versus local storage of patient identifiers (72.5% vs 48.0%, respectively, p = 0.006). Conclusions TRC methodology can be used to follow-up patients identified in prospective cohort studies at one-year. Follow-up rates are maximized by central storage of patient identifiers.
Issue Date: 12-Dec-2019
Date of Acceptance: 23-Oct-2019
URI: http://hdl.handle.net/10044/1/77912
DOI: 10.1186/s12874-019-0857-y
ISSN: 1471-2288
Publisher: BioMed Central
Start Page: 1
End Page: 7
Journal / Book Title: BMC Medical Research Methodology
Volume: 19
Issue: 1
Copyright Statement: © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Research collaborative
Surgery
Follow-up
Methodology
ACUTE KIDNEY INJURY
SURGICAL RESEARCH
MORTALITY
SURGERY
MULTICENTER
IMPACT
Follow-up
Methodology
Research collaborative
Surgery
STARSurg Collaborative
Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Research collaborative
Surgery
Follow-up
Methodology
ACUTE KIDNEY INJURY
SURGICAL RESEARCH
MORTALITY
SURGERY
MULTICENTER
IMPACT
General & Internal Medicine
1117 Public Health and Health Services
Publication Status: Published
Article Number: ARTN 237
Online Publication Date: 2019-12-12
Appears in Collections:Central Faculty