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Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy

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Title: Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy
Authors: Perry, H
Botnar, R
Wilton-Ely, J
Item Type: Journal Article
Abstract: Over the last decade, much work has been dedicated to improving the performance of gadolinium-based magnetic resonance imaging (MRI) contrast agents by tethering them to biocompatible gold nanoparticles. The enhancement in performance (measured in terms of ‘relaxivity’) stems from the restriction in motion experienced by the gadolinium chelates on being attached to the gold nanoparticle surface. More recently, the unique properties of gold nanoparticles have been exploited to create very promising tools for multimodal imaging and MRI-guided therapies. This review addresses the progress made in the design of gadolinium-functionalised gold nanoparticles for use in MRI, multimodal imaging and theranostics. It also seeks to connect the chemical properties of these assemblies with potential application in the clinic.
Issue Date: 14-Apr-2020
Date of Acceptance: 23-Mar-2020
URI: http://hdl.handle.net/10044/1/77618
DOI: 10.1039/d0cc00196a
ISSN: 1359-7345
Publisher: Royal Society of Chemistry (RSC)
Start Page: 4037
End Page: 4046
Journal / Book Title: Chemical Communications
Volume: 56
Issue: 29
Copyright Statement: © The Royal Society of Chemistry 2020
Sponsor/Funder: The Leverhulme Trust
Imperial College/Wellcome Trust Facility Network of Excellence scheme
Funder's Grant Number: RPG-2012-634
P52862
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
MRI CONTRAST AGENTS
PHOTOTHERMAL THERAPY
SURFACE FUNCTIONALIZATION
GRAPHENE OXIDE
IN-VITRO
NANOPARTICLES
CANCER
NANORODS
RELAXIVITY
NANOCLUSTERS
Organic Chemistry
03 Chemical Sciences
Publication Status: Published
Online Publication Date: 2020-03-23
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Grantham Institute for Climate Change
Faculty of Natural Sciences