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Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam
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Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam.pdf | Published version | 347.66 kB | Adobe PDF | View/Open |
Title: | Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam |
Authors: | Berto, A Anh, PH Carrique-Mas, JJ Simmonds, P Van Cuong, N Tue, NT Van Dung, N Woolhouse, ME Smith, I Marsh, GA Bryant, JE Thwaites, GE Baker, S Rabaa, MA |
Item Type: | Journal Article |
Abstract: | Bats and rodents are being increasingly recognized as reservoirs of emerging zoonotic viruses. Various studies have investigated bat viruses in tropical regions, but to date there are no data regarding viruses with zoonotic potential that circulate in bat and rat populations in Viet Nam. To address this paucity of data, we sampled three bat farms and three wet markets trading in rat meat in the Mekong Delta region of southern Viet Nam. Faecal and urine samples were screened for the presence of RNA from paramyxoviruses, coronaviruses and filoviruses. Paramyxovirus RNA was detected in 4 of 248 (1%) and 11 of 222 (4.9%) bat faecal and urine samples, respectively. Coronavirus RNA was detected in 55 of 248 (22%) of bat faecal samples; filovirus RNA was not detected in any of the bat samples. Further, coronavirus RNA was detected in 12 of 270 (4.4%) of rat faecal samples; all samples tested negative for paramyxovirus. Phylogenetic analysis revealed that the bat paramyxoviruses and bat and rat coronaviruses were related to viruses circulating in bat and rodent populations globally, but showed no cross‐species mixing of viruses between bat and rat populations within Viet Nam. Our study shows that potentially novel variants of paramyxoviruses and coronaviruses commonly circulate in bat and rat populations in Viet Nam. Further characterization of the viruses and additional human and animal surveillance is required to evaluate the likelihood of viral spillover and to assess whether these viruses pose a risk to human health. |
Issue Date: | 1-Feb-2018 |
Date of Acceptance: | 1-Apr-2017 |
URI: | http://hdl.handle.net/10044/1/67729 |
DOI: | https://dx.doi.org/10.1111/zph.12362 |
ISSN: | 0931-1793 |
Publisher: | Wiley |
Start Page: | 30 |
End Page: | 42 |
Journal / Book Title: | Zoonoses and Public Health |
Volume: | 65 |
Issue: | 1 |
Copyright Statement: | © 2017 The Authors. Zoonoses and Public Health Published by Blackwell Verlag GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Sponsor/Funder: | Wellcome Trust |
Funder's Grant Number: | 093724/E/10/Z |
Keywords: | Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Infectious Diseases Veterinary Sciences bats coronavirus paramyxovirus rats Viet Nam zoonotic viruses VIRUS-INFECTION FRUIT BATS CHINA DIVERSITY EVOLUTION EPIDEMIOLOGY MODELS RABIES Animals Chiroptera Coronavirus Feces Filoviridae Humans Paramyxoviridae Phylogeny RNA, Viral Rats Urine Vietnam VIZIONS consortium 06 Biological Sciences 07 Agricultural And Veterinary Sciences 11 Medical And Health Sciences |
Publication Status: | Published |
Online Publication Date: | 2017-04-18 |
Appears in Collections: | Department of Medicine (up to 2019) |