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Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion
| File | Description | Size | Format | |
|---|---|---|---|---|
 c8na00331a.pdf | Published version | 1.05 MB | Adobe PDF | View/Open |
| Title: | Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion |
| Authors: | Jumeaux, C Kim, E Howes, P Kim, H Chandrawati, R Stevens, M |
| Item Type: | Journal Article |
| Abstract: | We report the specific and sensitive detection of microRNA using an inverse DNA-mediated liposome fusion assay. This assay is homogeneous, and does not require washing, separation, or enzyme-associated amplification steps. By fine-tuning the surface functionalisation of the liposomes, liposome concentration, and assay temperature, we demonstrated a sub-nanomolar limit of detection for the target. |
| Issue Date: | 1-Feb-2019 |
| Date of Acceptance: | 14-Nov-2018 |
| URI: | http://hdl.handle.net/10044/1/66421 |
| DOI: | https://doi.org/10.1039/C8NA00331A |
| ISSN: | 2516-0230 |
| Publisher: | Royal Society of Chemistry |
| Start Page: | 532 |
| End Page: | 536 |
| Journal / Book Title: | Nanoscale Advances |
| Volume: | 1 |
| Issue: | 2 |
| Copyright Statement: | © 2018 The Author(s). This article is licensed under a Creative Commons Attribution 3.0 Unported Licence ( https://creativecommons.org/licenses/by/3.0/ ) |
| Sponsor/Funder: | Engineering & Physical Science Research Council (E Engineering & Physical Science Research Council (EPSRC) |
| Funder's Grant Number: | EP/K031953/1 EP/K020641/1 |
| Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science ARRAYS |
| Publication Status: | Published |
| Online Publication Date: | 2018-11-21 |
| Appears in Collections: | Materials Faculty of Natural Sciences Faculty of Engineering |