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3-D printing of chitosan-calcium phosphate inks: rheology, interactions and characterization
Title: | 3-D printing of chitosan-calcium phosphate inks: rheology, interactions and characterization |
Authors: | Caballero, SSR Saiz, E Montembault, A Tadier, S Maire, E David, L Delair, T Gremillard, L |
Item Type: | Journal Article |
Abstract: | Bone substitute fabrication is of interest to meet the worldwide incidence of bone disorders. Physical chitosan hydrogels with intertwined apatite particles were chosen to meet the bio-physical and mechanical properties required by a potential bone substitute. A set up for 3-D printing by robocasting was found adequate to fabricate scaffolds. Inks consisted of suspensions of calcium phosphate particles in chitosan acidic aqueous solution. The inks are shear-thinning and consist of a suspension of dispersed platelet aggregates of dicalcium phosphate dihydrate in a continuous chitosan phase. The rheological properties of the inks were studied, including their shear-thinning characteristics and yield stress. Scaffolds were printed in basic water/ethanol baths to induce transformation of chitosan-calcium phosphates suspension into physical hydrogel of chitosan mineralized with apatite. Scaffolds consisted of a chitosan polymeric matrix intertwined with poorly crystalline apatite particles. Results indicate that ink rheological properties could be tuned by controlling ink composition: in particular, more printable inks are obtained with higher chitosan concentration (0.19 mol·L−1). |
Issue Date: | 1-Jan-2019 |
Date of Acceptance: | 4-Dec-2018 |
URI: | http://hdl.handle.net/10044/1/66378 |
DOI: | https://dx.doi.org/10.1007/s10856-018-6201-y |
ISSN: | 0957-4530 |
Publisher: | Springer Verlag |
Journal / Book Title: | Journal of Materials Science: Materials in Medicine |
Volume: | 30 |
Issue: | 1 |
Copyright Statement: | © 2018 Springer Science+Business Media, LLC, part of Springer Nature. The final publication is available at Springer via https://dx.doi.org/10.1007/s10856-018-6201-y. |
Keywords: | Science & Technology Technology Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science SCAFFOLDS DERIVATIVES CERAMICS COMPOSITES STRENGTH 0903 Biomedical Engineering 0912 Materials Engineering Biomedical Engineering |
Publication Status: | Published |
Article Number: | 6 |
Online Publication Date: | 2018-12-29 |
Appears in Collections: | Materials Faculty of Engineering |