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Engineering extracellular vesicles with the tools of enzyme prodrug therapy
| File | Description | Size | Format | |
|---|---|---|---|---|
 Fuhrmann_et_al-2018-Advanced_Materials.pdf | Published version | 1.58 MB | Adobe PDF | View/Open |
| Title: | Engineering extracellular vesicles with the tools of enzyme prodrug therapy |
| Authors: | Fuhrmann, G Chandrawati, R Parmar, P Keane, TJ Maynard, SA Bertazzo, S Stevens, MM |
| Item Type: | Journal Article |
| Abstract: | Extracellular vesicles (EVs) have been exploited as drug delivery vehicles but their therapeutic use may be limited due to off-target effects. To harness EVs’inherent properties and to couple them with site-specific drug delivery functions, EVs are incorporated into hydrogels and engineered with the tools of enzyme-prodrug therapy. Local sustained release of anti-inflammatory drugs is demonstrated in macrophage cell models. |
| Issue Date: | 23-Feb-2018 |
| Date of Acceptance: | 21-Dec-2017 |
| URI: | http://hdl.handle.net/10044/1/55529 |
| DOI: | https://dx.doi.org/10.1002/adma.201706616 |
| ISSN: | 0935-9648 |
| Publisher: | Wiley |
| Journal / Book Title: | Advanced Materials |
| Volume: | 30 |
| Issue: | 15 |
| Copyright Statement: | © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Sponsor/Funder: | Medical Research Council (MRC) Medical Research Council (MRC) Commission of the European Communities Engineering & Physical Science Research Council (EPSRC) Wellcome Trust Commission of the European Communities Commission of the European Communities |
| Funder's Grant Number: | MR/L012677/1 MR/K026682/1 PIIF-GA-2011-299936 EP/K020641/1 098411/Z/12/Z ERC-2013-CoG-616417 746980 |
| Keywords: | enzyme prodrug therapy exosomes hydrogels microvesicles β-glucuronidase 02 Physical Sciences 03 Chemical Sciences 09 Engineering Nanoscience & Nanotechnology |
| Publication Status: | Published |
| Open Access location: | http://onlinelibrary.wiley.com/doi/10.1002/adma.201706616/abstract |
| Article Number: | 1706616 |
| Appears in Collections: | Materials Faculty of Natural Sciences Faculty of Engineering |