Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Barban, N; Jansen, R; De Vlaming, R; Vaez, A; Mandemakers, JJ; Tropf, FC; Shen, X; Wilson, JF; Chasman, DI; Nolte, IM; Tragante, V; Van der Laan, SW; Perry, JRB; Kong, A; Ahluwalia, TS; Albrecht, E; Yerges-Armstrong, L; Atzmon, G; Auro, K; Ayers, K; Bakshi, A; Ben-Avraham, D; Berger, K; Bergman, A; Bertram, L; Bielak, LF; Bjornsdottir, G; Bonder, MJ; Broer, L; Bui, M; Barbieri, C; Cavadino, A; Chavarro, JE; Turman, C; Concas, MP; Cordell, HJ; Davies, G; Eibich, P; Eriksson, N; Esko, T; Eriksson, J; Falahi, F; Felix, JF; Fontana, MA; Franke, L; Gandin, I; Gaskins, AJ; Gieger, C; Gunderson, EP; Guo, X; Hayward, C; He, C; Hofer, E; Huang, H; Joshi, PK; Kanoni, S; Karlsson, R; Kiechl, S; Kifley, A; Kluttig, A; Kraft, P; Lagou, V; Lecoeur, C; Lahti, J; Li-Gao, R; Lind, PA; Liu, T; Makalic, E; Mamasoula, C; Matteson, L; Mbarek, H; McArdle, PF; McMahon, G; Meddens, SFW; Mihailov, E; Miller, M; Missmer, SA; Monnereau, C; Van der Most, PJ; Myhre, R; Nalls, MA; Nutile, T; Kalafati, IP; Porcu, E; Prokopenko, I; Rajan, KB; Rich-Edwards, J; Rietveld, CA; Robino, A; Rose, LM; Rueedi, R; Ryan, K-A; Saba, Y; Schmidt, D; Smith, JA; Stolk, L; Streeten, E; Toenjes, A; Thorleifsson, G; Ulivi, S; Wedenoja, J; Wellmann, J; Willeit, P; Yao, J; Yengo, L; Zhao, JH; Zhao, W; Zhernakova, DV; Amin, N; Andrews, H; Balkau, B; Barzilai, N; Bergmann, S; Biino, G; Bisgaard, H; Bonnelykke, K; Boomsma, DI; Buring, JE; Campbell, H; Cappellani, S; Ciullo, M; Cox, SR; Cucca, F; Toniolo, D; Davey-Smith, G; Deary, IJ; Dedoussis, G; Deloukas, P; Van Duijn, CM; De Geus, EJC; Eriksson, JG; Evans, DA; Faul, JD; Sala, CF; Froguel, P; Gasparini, P; Girotto, G; Grabe, H-J; Greiser, KH; Groenen, PJF; De Haan, HG; Haerting, J; Harris, TB; Heath, AC; Heikkila, K; Hofman, A; Homuth, G; Holliday, EG; Hopper, J; Hypponen, E; Jacobsson, B; Jaddoe', VWV; Johannesson, M; Kahonen, M; Kajantie, E; Kardia, SLR; Keavney, B; Kolcic, I; Koponen, P; Kovacs, P; Kronenberg, F; Kutalik, Z; La Bianca, M; Lachance, G; Iacono, WG; Lai, S; Lehtimaki, T; Liewald, DC; Lindgren, CM; Liu, Y; Luben, R; Lucht, M; Luoto, R; Magnus, P; Magnusson, PKE; Martin, NG; McGue, M; McQuillan, R; Medland, SE; Meisinger, C; Mellstrom, D; Metspalu, A; Traglia, M; Milani, L; Mitchell, P; Montgomery, GW; Mook-Kanamori, D; De Mutsert, R; Nohr, EA; Ohlsson, C; Olsen, P; Ong, KK; Paternoster, L; Pattie, A; Penninx, BWJH; Perola, M; Peyser, PA; Pirastu, M; Polasek, O; Power, C; Kaprio, J; Raffel, LJ; Raikkonen, K; Raitakari, O; Ridker, PM; Ring, SM; Roll, K; Rudan, I; Ruggiero, D; Rujescu, D; Salomaa, V; Schlessinger, D; Schmidt, H; Schmidt, R; Schupf, N; Smit, J; Sorice, R; Spector, TD; Starr, JM; Stockl, D; Strauch, K; Stumvoll, M; Swertz, MA; Thorsteinsdottir, U; Thurik, AR; Timpson, NJ; Tung, JY; Uitterlinden, AG; Vaccargiu, S; Viikari, J; Vitart, V; Voelzke, H; Vollenweider, P; Vuckovic, D; Waage, J; Wagner, GG; Wang, JJ; Wareham, NJ; Weir, DR; Willemsen, G; Willeit, J; Wright, AF; Zondervan, KT; Stefansson, K; Krueger, RF; Lee, JJ; Benjamin, DJ; Cesarini, D; Koellinger, PD; Den Hoed, M; Snieder, H; Mills, MC

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Genome-wide analysis identifies 12 loci influencing human reproductive behavior

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Title:	Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Authors:	Barban, N Jansen, R De Vlaming, R Vaez, A Mandemakers, JJ Tropf, FC Shen, X Wilson, JF Chasman, DI Nolte, IM Tragante, V Van der Laan, SW Perry, JRB Kong, A Ahluwalia, TS Albrecht, E Yerges-Armstrong, L Atzmon, G Auro, K Ayers, K Bakshi, A Ben-Avraham, D Berger, K Bergman, A Bertram, L Bielak, LF Bjornsdottir, G Bonder, MJ Broer, L Bui, M Barbieri, C Cavadino, A Chavarro, JE Turman, C Concas, MP Cordell, HJ Davies, G Eibich, P Eriksson, N Esko, T Eriksson, J Falahi, F Felix, JF Fontana, MA Franke, L Gandin, I Gaskins, AJ Gieger, C Gunderson, EP Guo, X Hayward, C He, C Hofer, E Huang, H Joshi, PK Kanoni, S Karlsson, R Kiechl, S Kifley, A Kluttig, A Kraft, P Lagou, V Lecoeur, C Lahti, J Li-Gao, R Lind, PA Liu, T Makalic, E Mamasoula, C Matteson, L Mbarek, H McArdle, PF McMahon, G Meddens, SFW Mihailov, E Miller, M Missmer, SA Monnereau, C Van der Most, PJ Myhre, R Nalls, MA Nutile, T Kalafati, IP Porcu, E Prokopenko, I Rajan, KB Rich-Edwards, J Rietveld, CA Robino, A Rose, LM Rueedi, R Ryan, K-A Saba, Y Schmidt, D Smith, JA Stolk, L Streeten, E Toenjes, A Thorleifsson, G Ulivi, S Wedenoja, J Wellmann, J Willeit, P Yao, J Yengo, L Zhao, JH Zhao, W Zhernakova, DV Amin, N Andrews, H Balkau, B Barzilai, N Bergmann, S Biino, G Bisgaard, H Bonnelykke, K Boomsma, DI Buring, JE Campbell, H Cappellani, S Ciullo, M Cox, SR Cucca, F Toniolo, D Davey-Smith, G Deary, IJ Dedoussis, G Deloukas, P Van Duijn, CM De Geus, EJC Eriksson, JG Evans, DA Faul, JD Sala, CF Froguel, P Gasparini, P Girotto, G Grabe, H-J Greiser, KH Groenen, PJF De Haan, HG Haerting, J Harris, TB Heath, AC Heikkila, K Hofman, A Homuth, G Holliday, EG Hopper, J Hypponen, E Jacobsson, B Jaddoe', VWV Johannesson, M Kahonen, M Kajantie, E Kardia, SLR Keavney, B Kolcic, I Koponen, P Kovacs, P Kronenberg, F Kutalik, Z La Bianca, M Lachance, G Iacono, WG Lai, S Lehtimaki, T Liewald, DC Lindgren, CM Liu, Y Luben, R Lucht, M Luoto, R Magnus, P Magnusson, PKE Martin, NG McGue, M McQuillan, R Medland, SE Meisinger, C Mellstrom, D Metspalu, A Traglia, M Milani, L Mitchell, P Montgomery, GW Mook-Kanamori, D De Mutsert, R Nohr, EA Ohlsson, C Olsen, P Ong, KK Paternoster, L Pattie, A Penninx, BWJH Perola, M Peyser, PA Pirastu, M Polasek, O Power, C Kaprio, J Raffel, LJ Raikkonen, K Raitakari, O Ridker, PM Ring, SM Roll, K Rudan, I Ruggiero, D Rujescu, D Salomaa, V Schlessinger, D Schmidt, H Schmidt, R Schupf, N Smit, J Sorice, R Spector, TD Starr, JM Stockl, D Strauch, K Stumvoll, M Swertz, MA Thorsteinsdottir, U Thurik, AR Timpson, NJ Tung, JY Uitterlinden, AG Vaccargiu, S Viikari, J Vitart, V Voelzke, H Vollenweider, P Vuckovic, D Waage, J Wagner, GG Wang, JJ Wareham, NJ Weir, DR Willemsen, G Willeit, J Wright, AF Zondervan, KT Stefansson, K Krueger, RF Lee, JJ Benjamin, DJ Cesarini, D Koellinger, PD Den Hoed, M Snieder, H Mills, MC
Item Type:	Journal Article
Abstract:	The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
Issue Date:	31-Oct-2016
Date of Acceptance:	22-Sep-2016
URI:	http://hdl.handle.net/10044/1/53165
DOI:	https://dx.doi.org/10.1038/ng.3698
ISSN:	1061-4036
Publisher:	Nature Publishing Group
Start Page:	1462
End Page:	1472
Journal / Book Title:	Nature Genetics
Volume:	48
Issue:	12
Copyright Statement:	Copyright © 2016, Rights Managed by Nature Publishing Group
Keywords:	Science & Technology Life Sciences & Biomedicine Genetics & Heredity POLYCYSTIC-OVARY-SYNDROME GENE PRIORITIZATION QUALITY-CONTROL HUMAN-DISEASES G1 PHASE ASSOCIATION FERTILITY MOUSE PROTEIN AGE Birth Order Female Fertility Genome-Wide Association Study Humans Maternal Age Parity Phenotype Polymorphism, Single Nucleotide Pregnancy Quantitative Trait Loci Reproduction Reproductive Behavior BIOS Consortium LifeLines Cohort Study 11 Medical And Health Sciences 06 Biological Sciences Developmental Biology
Publication Status:	Published
Appears in Collections:	Department of Medicine (up to 2019)