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A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
| File | Description | Size | Format | |
|---|---|---|---|---|
 A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.pdf | Accepted version | 1.7 MB | Adobe PDF | View/Open |
| Title: | A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease |
| Authors: | Nikpay, M Goel, A Won, H-H Hall, LM Willenborg, C Kanoni, S Saleheen, D Kyriakou, T Nelson, CP Hopewell, JC Webb, TR Zeng, L Dehghan, A Alver, M Armasu, SM Auro, K Bjonnes, A Chasman, DI Chen, S Ford, I Franceschini, N Gieger, C Grace, C Gustafsson, S Huang, J Hwang, S-J Kim, YK Kleber, ME Lau, KW Lu, X Lu, Y Lyytikainen, L-P Mihailov, E Morrison, AC Pervjakova, N Qu, L Rose, LM Salfati, E Saxena, R Scholz, M Smith, AV Tikkanen, E Uitterlinden, A Yang, X Zhang, W Zhao, W De Andrade, M De Vries, PS Van Zuydam, NR Anand, SS Bertram, L Beutner, F Dedoussis, G Frossard, P Gauguier, D Goodall, AH Gottesman, O Haber, M Han, B-G Huang, J Jalilzadeh, S Kessler, T Koenig, IR Lannfelt, L Lieb, W Lind, L Lindgren, CM Lokki, M-L Magnusson, PK Mallick, NH Mehra, N Meitinger, T Memon, F-U-R Morris, AP Nieminen, MS Pedersen, NL Peters, A Rallidis, LS Rasheed, A Samuel, M Shah, SH Sinisalo, J Stirrups, KE Trompet, S Wang, L Zaman, KS Ardissino, D Boerwinkle, E Borecki, IB Bottinger, EP Buring, JE Chambers, JC Collins, R Cupples, LA Danesh, J Demuth, I Elosua, R Epstein, SE Esko, T Feitosa, MF Franco, OH Franzosi, MG Granger, CB Gu, D Gudnason, V Hall, AS Hamsten, A Harris, TB Hazen, SL Hengstenberg, C Hofman, A Ingelsson, E Iribarren, C Jukema, JW Karhunen, PJ Kim, B-J Kooner, JS Kullo, IJ Lehtimaki, T Loos, RJF Melander, O Metspalu, A Maerz, W Palmer, CN Perola, M Quertermous, T Rader, DJ Ridker, PM Ripatti, S Roberts, R Salomaa, V Sanghera, DK Schwartz, SM Seedorf, U Stewart, AF Stott, DJ Thiery, J Zalloua, PA O'Donnell, CJ Reilly, MP Assimes, TL Thompson, JR Erdmann, J Clarke, R Watkins, H Kathiresan, S McPherson, R Deloukas, P Schunkert, H Samani, NJ Farrall, M |
| Item Type: | Journal Article |
| Abstract: | Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of 185 thousand CAD cases and controls, interrogating 6.7 million common (MAF>0.05) as well as 2.7 million low frequency (0.005<MAF<0.05) variants. In addition to confirmation of most known CAD loci, we identified 10 novel loci, eight additive and two recessive, that contain candidate genes that newly implicate biological processes in vessel walls. We observed intra-locus allelic heterogeneity but little evidence of low frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size |
| Issue Date: | 7-Sep-2015 |
| Date of Acceptance: | 1-Sep-2015 |
| URI: | http://hdl.handle.net/10044/1/49225 |
| DOI: | https://dx.doi.org/10.1038/ng.3396 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Start Page: | 1121 |
| End Page: | 1130 |
| Journal / Book Title: | Nature Genetics |
| Volume: | 47 |
| Issue: | 10 |
| Copyright Statement: | © 2015, Rights Managed by Nature Publishing Group |
| Keywords: | Science & Technology Life Sciences & Biomedicine Genetics & Heredity HEART-DISEASE CARDIOVASCULAR-DISEASE MYOCARDIAL-INFARCTION SUSCEPTIBILITY LOCUS GENETIC-VARIANTS CELL-MIGRATION IDENTIFIES 13 MICE LACKING EXPRESSION RISK Coronary Artery Disease Genome, Human Genome-Wide Association Study Humans Phenotype CARDIoGRAMplusC4D Consortium Developmental Biology 11 Medical And Health Sciences 06 Biological Sciences |
| Publication Status: | Published |
| Appears in Collections: | School of Public Health |