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Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes
File | Description | Size | Format | |
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c6sc02118b.pdf | Published version | 2.47 MB | Adobe PDF | View/Open |
Title: | Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes |
Authors: | Almond-Thynne, J Blakemore, DC Pryde, DC Spivey, AC |
Item Type: | Journal Article |
Abstract: | Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found. |
Issue Date: | 9-Aug-2016 |
Date of Acceptance: | 4-Aug-2016 |
URI: | http://hdl.handle.net/10044/1/44233 |
DOI: | http://dx.doi.org/10.1039/c6sc02118b |
ISSN: | 2041-6539 |
Publisher: | Royal Society of Chemistry |
Start Page: | 40 |
End Page: | 62 |
Journal / Book Title: | Chemical Science |
Volume: | 8 |
Issue: | 1 |
Copyright Statement: | © 2016 The Authors. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/). |
Keywords: | Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry ONE-POT SYNTHESIS LIGHT-EMITTING-DIODES BOND-DISSOCIATION ENERGIES ESTROGEN-RECEPTOR LIGANDS DINUCLEAR PD(I) COMPLEXES ARYL BORONIC ACIDS EFFICIENT SYNTHESIS OXIDATIVE ADDITION ARYLBORONIC ACIDS KINASE INHIBITORS |
Publication Status: | Published |
Appears in Collections: | Chemistry Faculty of Natural Sciences |