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Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes

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Title: Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes
Authors: Almond-Thynne, J
Blakemore, DC
Pryde, DC
Spivey, AC
Item Type: Journal Article
Abstract: Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
Issue Date: 9-Aug-2016
Date of Acceptance: 4-Aug-2016
URI: http://hdl.handle.net/10044/1/44233
DOI: http://dx.doi.org/10.1039/c6sc02118b
ISSN: 2041-6539
Publisher: Royal Society of Chemistry
Start Page: 40
End Page: 62
Journal / Book Title: Chemical Science
Volume: 8
Issue: 1
Copyright Statement: © 2016 The Authors. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
ONE-POT SYNTHESIS
LIGHT-EMITTING-DIODES
BOND-DISSOCIATION ENERGIES
ESTROGEN-RECEPTOR LIGANDS
DINUCLEAR PD(I) COMPLEXES
ARYL BORONIC ACIDS
EFFICIENT SYNTHESIS
OXIDATIVE ADDITION
ARYLBORONIC ACIDS
KINASE INHIBITORS
Publication Status: Published
Appears in Collections:Chemistry
Faculty of Natural Sciences