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Circadian clocks and breast cancer

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Title: Circadian clocks and breast cancer
Authors: Blakeman, V
Williams, JL
Meng, Q-J
Streuli, CH
Item Type: Journal Article
Abstract: Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes. Disrupted expression of circadian genes can alter breast biology and may promote cancer. Here we overview circadian mechanisms, and the connection between the molecular clock and breast biology. We describe how disruption of circadian genes contributes to cancer via multiple mechanisms, and link this to increased tumour risk in women who work irregular shift patterns. Understanding the influence of circadian rhythms on breast cancer could lead to more efficacious therapies, reformed public health policy and improved patient outcome.
Issue Date: 2-Sep-2016
Date of Acceptance: 1-Sep-2016
URI: http://hdl.handle.net/10044/1/43052
DOI: https://dx.doi.org/10.1186/s13058-016-0743-z
ISSN: 1465-5411
Publisher: BioMed Central
Journal / Book Title: Breast Cancer Research
Volume: 18
Issue: 1
Copyright Statement: © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Open Access location: https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0743-z
Article Number: 89
Appears in Collections:Central Faculty