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A composite hydrogel for brain tissue phantoms
File | Description | Size | Format | |
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JMAD-D-16-04151_Accepted_Version.pdf | Accepted version | 1.32 MB | Adobe PDF | View/Open |
1-s2.0-S0264127516312370-main.pdf | Published version | 1.84 MB | Unknown | View/Open |
Title: | A composite hydrogel for brain tissue phantoms |
Authors: | Forte, AE Galvan, S Manieri, F Rodriguez y Baena, F Dini, D |
Item Type: | Journal Article |
Abstract: | Synthetic phantoms are valuable tools for training, research and development in traditional and computer aided surgery, but complex organs, such as the brain, are difficult to replicate. Here, we present the development of a new composite hydrogel capable of mimicking the mechanical response of brain tissue under loading. Our results demonstrate how the combination of two different hydrogels, whose synergistic interaction results in a highly tunable blend, produces a hybrid material that closely matches the strongly dynamic and non-linear response of brain tissue. The new synthetic material is inexpensive, simple to prepare, and its constitutive components are both widely available and biocompatible. Our investigation of the properties of this engineered tissue, using both small scale testing and life-sized brain phantoms, shows that it is suitable for reproducing the brain shift phenomenon and brain tissue response to indentation and palpation. |
Issue Date: | 19-Sep-2016 |
Date of Acceptance: | 17-Sep-2016 |
URI: | http://hdl.handle.net/10044/1/40486 |
DOI: | http://dx.doi.org/10.1016/j.matdes.2016.09.063 |
ISSN: | 0264-1275 |
Publisher: | Elsevier |
Start Page: | 227 |
End Page: | 238 |
Journal / Book Title: | Materials and Design |
Volume: | 112 |
Replaces: | 10044/1/41101 http://hdl.handle.net/10044/1/41101 |
Copyright Statement: | Available under a CC BY license. |
Sponsor/Funder: | Commission of the European Communities Engineering & Physical Science Research Council (E Commission of the European Communities Engineering & Physical Science Research Council (EPSRC) |
Funder's Grant Number: | 270460 EP/K503733/1 688279 EP/N025954/1 |
Keywords: | Materials Materials Engineering Mechanical Engineering |
Publication Status: | Published |
Appears in Collections: | Mechanical Engineering Bioengineering Faculty of Natural Sciences Faculty of Engineering |