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25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966
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25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966.pdf | Published version | 177.48 kB | Adobe PDF | View/Open |
Title: | 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966 |
Authors: | Williams, DM Palaniswamy, S Sebert, S Buxton, JL Blakemore, AIF Hyppoenen, E Jarvelin, M-R |
Item Type: | Journal Article |
Abstract: | Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)2) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = −0.4%, 95% confidence interval: −0.6, −0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = −0.3%, 95% confidence interval −0.6, −0.1). These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at least by young adulthood. Inflammation may partly mediate associations of adiposity with LTL. |
Issue Date: | 20-Jan-2016 |
Date of Acceptance: | 28-Jul-2015 |
URI: | http://hdl.handle.net/10044/1/40397 |
DOI: | http://dx.doi.org/10.1093/aje/kwv203 |
ISSN: | 1476-6256 |
Publisher: | Oxford University Press |
Start Page: | 191 |
End Page: | 198 |
Journal / Book Title: | American Journal of Epidemiology |
Volume: | 183 |
Issue: | 3 |
Copyright Statement: | © The Author 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Sponsor/Funder: | Wellcome Trust |
Funder's Grant Number: | 088431/Z/09/Z |
Keywords: | Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health biological aging Northern Finland Birth Cohorts telomere length vitamin D VITAMIN-D STATUS BODY-MASS INDEX MENDELIAN RANDOMIZATION CARDIOVASCULAR-DISEASE D DEFICIENCY ASSOCIATION RISK METAANALYSIS WOMEN MORTALITY Adiposity Adult Body Mass Index C-Reactive Protein Cross-Sectional Studies Female Finland Humans Leukocytes Male Prospective Studies Telomere Homeostasis Vitamin D Epidemiology 11 Medical And Health Sciences 01 Mathematical Sciences |
Publication Status: | Published |
Appears in Collections: | Department of Medicine (up to 2019) |