A syntenic cross species aneuploidy genetic screen links RCAN1 expression to beta-cell mitochondrial dysfunction in type 2 Diabetes

Title:	A syntenic cross species aneuploidy genetic screen links RCAN1 expression to beta-cell mitochondrial dysfunction in type 2 Diabetes
Authors:	Peiris, H Duffield, MD Fadista, J Jessup, CF Kashmir, V Genders, AJ Mcgee, SL Martin, AM Saiedi, M Morton, N Carter, R Cousin, MA Kokotos, AC Oskolkov, N Volkov, P Hough, TA Fisher, EMC Tybulewicz, VLJ Busciglio, J Coskun, PE Becker, A Belichenko, PV Mobley, WC Ryan, MT Chan, JY Laybutt, DR Coates, PT Yang, S Ling, C Groop, L Pritchard, MA Keating, DJ
Item Type:	Journal Article
Issue Date:	19-May-2016
Date of Acceptance:	18-Apr-2016
URI:	http://hdl.handle.net/10044/1/34586
DOI:	https://dx.doi.org/10.1371/journal.pgen.1006033
ISSN:	1553-7390
Publisher:	Public Library of Science
Journal / Book Title:	PLOS Genetics
Volume:	12
Issue:	5
Copyright Statement:	© 2016 Peiris et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords:	Science & Technology Life Sciences & Biomedicine Genetics & Heredity Sydrome critical region Human pancreatic-islets Down-syndrome Oxidative stress In-vitro Glucose Metaolism Protein Model DSCR1 Developmental Biology Genetics
Publication Status:	Published
Article Number:	ARTN e1006033
Appears in Collections:	Department of Medicine (up to 2019)