Protocol for repeated Plasmodium chabaudi infection in a murine malaria model
File(s)
Published version
Author(s)
Bruno, Federica
Langhorne, Jean
Lo Celso, Cristina
Type
Journal Article
Abstract
In malaria-endemic regions, individuals experience repeated malaria infection throughout life. Here, we present a protocol to investigate the immunological mechanisms triggered by repeated exposure using a murine model of sequential infections with the rodent parasite Plasmodium chabaudi chabaudi. We provide a detailed and standardized series of steps covering primary infection, natural recovery without treatment, and subsequent secondary infection. This approach offers a robust framework to investigate the effects and long-term consequences of repeated malaria infections on the host.
Date Issued
2026-12-18
Date Acceptance
2026-09-04
Citation
STAR Protocols, 2026, 7 (4)
ISSN
2666-1667
Publisher
Elsevier
Journal / Book Title
STAR Protocols
Volume
7
Issue
4
Copyright Statement
© 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
10.1016/j.xpro.2026.104850
Publication Status
Published
Article Number
104850
Date Publish Online
2026-09-21