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High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler
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 s41587-023-01825-5.pdf | Published version | 1.6 MB | Adobe PDF | View/Open |
| Title: | High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler |
| Authors: | Sych, T Schlegel, J Barriga, HMG Ojansivu, M Hanke, L Weber, F Bostancioglu, RB Ezzat, K Stangl, H Plochberger, B Laurencikiene, J El Andaloussi, S Fuerth, D Stevens, MM Sezgin, E |
| Item Type: | Journal Article |
| Abstract: | We introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5–200 nm. We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses. |
| Issue Date: | 1-Apr-2024 |
| Date of Acceptance: | 10-May-2023 |
| URI: | http://hdl.handle.net/10044/1/108029 |
| DOI: | 10.1038/s41587-023-01825-5 |
| ISSN: | 1087-0156 |
| Publisher: | Nature Research |
| Start Page: | 587 |
| End Page: | 590 |
| Journal / Book Title: | Nature Biotechnology |
| Volume: | 42 |
| Copyright Statement: | © The Author(s) 2023 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Publication Status: | Published |
| Online Publication Date: | 2023-06-12 |
| Appears in Collections: | Materials Faculty of Natural Sciences Faculty of Engineering |
This item is licensed under a Creative Commons License
