Altmetric
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
| File | Description | Size | Format | |
|---|---|---|---|---|
 Cellular and molecular features of COVID-19 associated ARDS therapeutic relevance.pdf | Published version | 1.89 MB | Adobe PDF | View/Open |
| Title: | Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance |
| Authors: | Scaramuzzo, G Francesco, N Asmundo, A Messina, R Mari, M Montanaro, F Johansen, MD Monaco, F Fadda, G Tuccari, G Hansbro, NG Hansbro, PM Hansel, TT Adcock, IM David, A Kirkham, P Caramori, G Volta, CA Spadaro, S |
| Item Type: | Journal Article |
| Abstract: | The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS. |
| Issue Date: | 20-Mar-2023 |
| Date of Acceptance: | 8-Feb-2023 |
| URI: | http://hdl.handle.net/10044/1/107909 |
| DOI: | 10.1186/s12950-023-00333-2 |
| ISSN: | 1476-9255 |
| Publisher: | BMC |
| Journal / Book Title: | Journal of Inflammation |
| Volume: | 20 |
| Copyright Statement: | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Publication Status: | Published |
| Article Number: | 11 |
| Online Publication Date: | 2023-03-20 |
| Appears in Collections: | National Heart and Lung Institute Imperial College London COVID-19 |
This item is licensed under a Creative Commons License
