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A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection
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A balanced type 1type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection.pdf | Published version | 1.16 MB | Adobe PDF | View/Open |
Title: | A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection |
Authors: | Imami, N Pires, A Hardy, G Wilson, J Gazzard, B Gotch, F |
Item Type: | Journal Article |
Abstract: | Previous reports have emphasized the requirements for strong type 1 cell-mediated responses in the control of human immunodeficiency virus type 1 (HIV-1). HIV-1 Gag p24-specific CD4 helper T-lymphocyte (HTL) responses have been shown to inversely correlate with viral burden in HIV-1-infected individuals. In this study, peripheral blood mononuclear cells from 70 individuals with chronic progressive HIV-1 infection (clinical progressors), 10 clinical nonprogressors, and 3 immunologically discordant progressors were assessed for HTL proliferation and type 1/type 2 cytokine production. Clinical progressors lacked functional HIV-1-specific HTLs with proliferative and cytokine-producing capacity. Clinical nonprogressors were found to respond to a wide range of HIV-1 antigens from different clades, producing both type 1 and type 2 cytokines. Immunologically discordant progressors responded strongly to clade B Gag p24 with a type 1 cytokine profile but not to other antigens. Thus, in contrast to clinical nonprogressors, neither progressors nor immunologically discordant progressors secreted interleukin-4 (IL-4) in response to HIV-1 antigens. Both clinical nonprogressors and immunologically discordant progressors responded broadly to B clade Gag p24-overlapping peptides. However, IL-4 production in the nonprogressors was restricted to a limited number of p24 peptides. No HIV-1-specific T-cell responses were seen in 20 seronegative controls. Additionally, we observed a rapid type 1 to type 2 shift in the response of one immunologically discordant progressor upon onset of clinical symptoms. These results suggest that a balanced type 1/type 2 profile correlates with successful long-term control of HIV-1. |
Issue Date: | Sep-2002 |
Date of Acceptance: | 1-Sep-2002 |
URI: | http://hdl.handle.net/10044/1/105745 |
DOI: | 10.1128/JVI.76.18.9011-9023.2002 |
ISSN: | 0022-538X |
Publisher: | American Society for Microbiology |
Start Page: | 9011 |
End Page: | 9023 |
Journal / Book Title: | Journal of Virology |
Volume: | 76 |
Issue: | 18 |
Copyright Statement: | Copyright © 2002, American Society for Microbiology. All Rights Reserved. |
Publication Status: | Published |
Online Publication Date: | 2002-09-15 |
Appears in Collections: | Department of Infectious Diseases |