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4-Membered ring carbocations: a positive development in the synthesis of 3,3-disubstituted oxetanes and azetidines

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Title: 4-Membered ring carbocations: a positive development in the synthesis of 3,3-disubstituted oxetanes and azetidines
Authors: Rojas, JJ
Bull, J
Item Type: Journal Article
Abstract: 4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant. Here, we describe the generation of oxetane- and azetidine- benzylic carbocations as a general strategy to access valuable 3,3-disubstituted derivatives.
Issue Date: 26-Apr-2023
Date of Acceptance: 27-Feb-2023
URI: http://hdl.handle.net/10044/1/103373
DOI: 10.2533/chimia.2023.192
ISSN: 2673-2424
Publisher: Schweizerische Chemische Gesellschaft
Start Page: 192
End Page: 195
Journal / Book Title: CHIMIA
Volume: 77
Issue: 4
Copyright Statement: © J. J. Rojas, J. A. Bull. This work is licensed under a Creative Commons Attribution 4.0 International License. The material may not be used for commercial purposes. The license is subject to the CHIMIA terms and conditions: (https://chimia.ch/chimia/about). The definitive version of this article is the electronic one that can be found at https://doi.org/10.2533/chimia.2023.192
Publication Status: Published
Online Publication Date: 2023-04-26
Appears in Collections:Chemistry
Faculty of Natural Sciences



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