Post-tuberculosis lung disease: towards prevention, diagnosis and care
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
There is a growing body of data describing the high burden of respiratory sequelae seen among tuberculosis survivors, including children, adolescents, and adults. This group of sequelae are known as post-tuberculosis lung disease and include parenchymal damage, airway disease, and pulmonary vascular disease. It is thought that approximately half of pulmonary tuberculosis survivors have ongoing structural pathology, lung function impairment, or respiratory symptoms after the resolution of active disease. Post-tuberculosis lung disease has been associated with adverse patient outcomes, including persistent symptoms and functional impairment, ongoing health seeking, and impacts on income and employment. There is still much to understand about the epidemiology and nature of post-tuberculosis lung disease, but in this Review we focus on strategies for prevention, diagnosis, and care to inform the ongoing work of tuberculosis-affected communities, health-care providers, researchers, and policy makers. We summarise recent data, highlight evidence gaps, and suggest key research priorities for those working in the field.
Date Issued
2025-05-01
Date Acceptance
2024-12-18
Citation
The Lancet Respiratory Medicine, 2025, 13 (5), pp.460-472
ISSN
2213-2600
Publisher
Elsevier
Start Page
460
End Page
472
Journal / Book Title
The Lancet Respiratory Medicine
Volume
13
Issue
5
Copyright Statement
Copyright © 2025 Elsevier Ltd. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Publication Status
Published
Date Publish Online
2025-03-22