Association between high levels of gynoid fat and the increase of bone mineral density in women
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Introduction: In women, bone mineral density (BMD) is related to age, estrogenic action, and appendicular skeletal muscle mass (ASMM). The gynoid fat distribution is linked to estrogenic action.Objective: This study aimed to assess whether an increase of gynoid fat is associated with high BMD independent of age and ASMM.Methods: An observational study was performed in women aged between 20 and 79 years. Fat mass, ASMM, and BMD were measured with dual-energy X-ray absorptiometry. The binned scatterplots and multivariate linear regression models were used to study the relationship between hip BMD and age, height, android fat, gynoid fat, and ASMM.Results: Of 673 women invited, 596 accepted to participate. Their mean age was 55.4 ± 12.8 years, weight 63.4 ± 9.4 kg, height 1.61 ± 0.06 m, body mass index 24.54 ± 3.59 kg/m2, average hip BMD 0.914 ± 0.122 g/cm2, android fat 2.12 ± 0.83 kg, gynoid fat 4.54 ± 1.07 kg, and ASMM 15.15 ± 1.97 kg. The final regression model included age (linear coefficient -0.004; 95% confidence interval [CI]: -0.005 to -0.003; p < 0.001), ASMM (linear coefficient 0.013; 95% CI: 0.009 to 0.018; p < 0.001), and gynoid fat (linear coefficient 0.013; 95% CI: 0.005 to 0.022; p < 0.002).Conclusion: Gynoid fat is associated with BMD in the hip independently of age and ASMM.
Date Issued
2020
Date Acceptance
2019-10-02
Citation
Climacteric, 2020, 23 (2), pp.206-210
ISSN
1369-7137
Publisher
Taylor & Francis
Start Page
206
End Page
210
Journal / Book Title
Climacteric
Volume
23
Issue
2
Copyright Statement
© 2019 Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Climacteric on 18 Nov 2019, available online: https://www.tandfonline.com/doi/full/10.1080/13697137.2019.1679112
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31736370
Subjects
Body fat
bone mineral density
gynoid fat
women
Publication Status
Published online
Coverage Spatial
England
Date Publish Online
2019-11-18