Engineered bioactive glass-chitosan hybrid for dual tissue and bone regeneration multifunctional healing
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
The treatment of complex wounds, particularly those arising from conditions such as diabetes or trauma, presents a significant clinical challenge. These wounds often necessitate long-term care for soft tissue and bone repair, creating an urgent need for multifunctional wound dressings. This study introduces a chitosan-silica hybrid dressing enhanced with bioactive glass (BG), specifically designed to address this need. The hybrid material achieves molecular bonding through coupling agents, with the organic chitosan component providing swelling and hemostatic effects, while the inorganic silica and BG release ions (Si4+, Ca2+), promoting tissue regeneration and bone healing. With a controlled degradation profile (lasting 3 to 6 months in-vitro), the dressing is ideal for chronic wound management. Experimental results demonstrate excellent biocompatibility, no inflammatory response, and strong hemostatic properties due to the positively charged chitosan and cations. Adding BG significantly enhances bone regeneration, positioning this chitosan-silica hybrid as a promising solution for the simultaneous repair of soft tissue and bone.
Date Issued
2025-11-01
Date Acceptance
2025-05-06
Citation
Biomaterials Advances, 2025, 176
ISSN
2772-9508
Publisher
Elsevier
Start Page
214340
End Page
214340
Journal / Book Title
Biomaterials Advances
Volume
176
Copyright Statement
Copyright © 2025 Published by Elsevier B.V. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Subjects
Animals
Humans
Silicon Dioxide
Chitosan
Glass
Biocompatible Materials
Tissue Engineering
Bandages
Bone Regeneration
Wound Healing
Publication Status
Published
Article Number
214340
Date Publish Online
2025-05-08