Effects of dyslipidaemia on monocyte production and function in cardiovascular disease.
File(s)
Author(s)
Rahman, MS
Murphy, AJ
Woollard, KJ
Type
Journal Article
Abstract
Monocytes are heterogeneous effector cells involved in the maintenance and restoration of tissue integrity. Monocytes and macrophages are involved in cardiovascular disease progression, and are associated with the development of unstable atherosclerotic plaques. Hyperlipidaemia can accelerate cardiovascular disease progression. However, monocyte responses to hyperlipidaemia are poorly understood. In the past decade, accumulating data describe the relationship between the dynamic blood lipid environment and the heterogeneous circulating monocyte pool, which might have profound consequences for cardiovascular disease. In this Review, we explore the updated view of monocytes in cardiovascular disease and their relationship with macrophages in promoting the homeostatic and inflammatory responses related to atherosclerosis. We describe the different definitions of dyslipidaemia, highlight current theories on the ontogeny of monocyte heterogeneity, discuss how dyslipidaemia might alter monocyte production, and explore the mechanistic interface linking dyslipidaemia with monocyte effector functions, such as migration and the inflammatory response. Finally, we discuss the role of dietary and endogenous lipid species in mediating dyslipidaemic responses, and the role of these lipids in promoting the risk of cardiovascular disease through modulation of monocyte behaviour.
Date Issued
2017-03-16
Date Acceptance
2017-03-01
Citation
Nature Reviews Cardiology, 2017, 14, pp.387-400
ISSN
1759-5010
Publisher
Nature Publishing Group
Start Page
387
End Page
400
Journal / Book Title
Nature Reviews Cardiology
Volume
14
Copyright Statement
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The final publication is available at https://dx.doi.org/10.1038/nrcardio.2017.34
Sponsor
British Heart Foundation
Identifier
PII: nrcardio.2017.34
Grant Number
FS/14/50/30856
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
HIGH-DENSITY-LIPOPROTEIN
CORONARY-ARTERY-DISEASE
STEM-CELL PROLIFERATION
TRIGLYCERIDE-RICH LIPOPROTEINS
RETINYL PALMITATE RESPONSES
GENE-EXPRESSION PROFILES
BLOOD MONONUCLEAR-CELLS
ISCHEMIC-HEART-DISEASE
SATURATED FATTY-ACIDS
APOE-DEFICIENT MICE
Cardiovascular System & Hematology
Publication Status
Published