INSIGHTS INTO THE ROLE OF NEURONAL GLUCOKINASE
File(s)
Published version
Author(s)
Gardiner, JV
bloom, SR
Hussain, S
De Backer, I
Type
Journal Article
Abstract
Glucokinase is a key component of the neuronal glucose-sensing mechanism and is expressed in brain regions that control a range of homeostatic processes. In this review, we detail recently identified roles for neuronal glucokinase in glucose homeostasis and counter-regulatory responses to hypoglycaemia and in regulating appetite. We describe clinical implications from these advances in our knowledge especially for developing novel treatments for diabetes and obesity. Further research required to extend our knowledge and help our efforts to tackle the diabetes and obesity epidemics are suggested.
Date Issued
2016-05-17
Date Acceptance
2016-05-13
Citation
American Journal of Physiology-Endocrinology and Metabolism, 2016, 311 (1), pp.E42-E55
ISSN
1522-1555
Publisher
American Physiological Society
Start Page
E42
End Page
E55
Journal / Book Title
American Journal of Physiology-Endocrinology and Metabolism
Volume
311
Issue
1
Copyright Statement
Copyright © 2016 the American Physiological Society
Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society.
Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society.
License URL
Sponsor
Biotechnology and Biological Sciences Research Cou
Biotechnology and Biological Sciences Research Council (BBSRC)
Wellcome Trust
Grant Number
BB/E52708X/1
BB/I00842X/1
095112/Z/10/Z
Subjects
Appetite
Glucokinase
Glucose-sensing
Homeostasis
Neuronal
Endocrinology & Metabolism
06 Biological Sciences
11 Medical And Health Sciences
Publication Status
Published