Latent variable mixture modeling in psychiatric research - a review and application
File(s)Miettunen et al Latent variable review 010615.docx (72.18 KB)
Accepted version
Author(s)
Miettunen, J
Nordstrom, T
Kaakinen, M
Ahmed, AO
Type
Journal Article
Abstract
Latent variable mixture modeling represents a flexible approach to investigating population heterogeneity by sorting
cases into latent but non-arbitrary subgroups that are more homogeneous. The purpose of this selective review is to provide
a non-technical introduction to mixture modeling in a cross-sectional context. Latent class analysis is used to classify
individuals into homogeneous subgroups (latent classes). Factor mixture modeling represents a newer approach that
represents a fusion of latent class analysis and factor analysis. Factor mixture models are adaptable to representing categorical
and dimensional states of affairs. This article provides an overview of latent variable mixture models and illustrates
the application of these methods by applying them to the study of the latent structure of psychotic experiences. The
flexibility of latent variable mixture models makes them adaptable to the study of heterogeneity in complex psychiatric
and psychological phenomena. They also allow researchers to address research questions that directly compare the viability
of dimensional, categorical and hybrid conceptions of constructs.
cases into latent but non-arbitrary subgroups that are more homogeneous. The purpose of this selective review is to provide
a non-technical introduction to mixture modeling in a cross-sectional context. Latent class analysis is used to classify
individuals into homogeneous subgroups (latent classes). Factor mixture modeling represents a newer approach that
represents a fusion of latent class analysis and factor analysis. Factor mixture models are adaptable to representing categorical
and dimensional states of affairs. This article provides an overview of latent variable mixture models and illustrates
the application of these methods by applying them to the study of the latent structure of psychotic experiences. The
flexibility of latent variable mixture models makes them adaptable to the study of heterogeneity in complex psychiatric
and psychological phenomena. They also allow researchers to address research questions that directly compare the viability
of dimensional, categorical and hybrid conceptions of constructs.
Date Issued
2015-11-03
Date Acceptance
2015-10-01
Citation
Psychological Medicine, 2015, 46 (3), pp.457-467
ISSN
0033-2917
Publisher
Cambridge University Press
Start Page
457
End Page
467
Journal / Book Title
Psychological Medicine
Volume
46
Issue
3
Copyright Statement
© 2015 Cambridge University Press. This paper has been accepted for publication and will appear in a revised form, subsequent to peer-review and/or editorial input by Cambridge University Press.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367172500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Clinical
Psychiatry
Psychology
Factor mixture models
latent class analysis
psychosis
statistics
CONFIRMATORY FACTOR-ANALYSIS
NATIONAL-COMORBIDITY-SURVEY
SCHIZOTYPAL PERSONALITY
GENERAL-POPULATION
PSYCHOPATHOLOGY RESEARCH
PSYCHOTIC EXPERIENCES
ABNORMAL-PERSONALITY
MONTE-CARLO
SAMPLE-SIZE
PART I
Cross-Sectional Studies
Factor Analysis, Statistical
Humans
Models, Psychological
Models, Statistical
Psychotic Disorders
1701 Psychology
1117 Public Health And Health Services
1109 Neurosciences
Publication Status
Published